Abstract:The current work aimed to formulate Darunavir (DRV) loaded poly (ɛ-caprolactone) nanoparticles (NPs) to address the issue of low bioavailability. NPs were formulated by employing D-α Tocopherol Polyethylene Glycol Succinate 1,000 (TPGS) as stabilizer using the solvent emulsification-evaporation technique. The optimized batch had a mean particle size of 173.74 ± 8.01 nm with polydispersity index 0.218 ± 0.01. Entrapment efficiency, drug loading, zeta potential and yield were found to be 82.32 ± 4.18%, 36.57 ± 1… Show more
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