Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery

Park, Jung Hwan; Allen, Mark G.; Prausnitz, Mark R.

doi:10.1016/j.jconrel.2005.02.002

Cited by 802 publications

(522 citation statements)

References 27 publications

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“…This leaves the drug to diffuse across the viable skin (which consists of the viable epidermis and dermis) into the blood microcirculation. Assuming steady state transport across skin (Park et al, 2005), the effective permeability P eff of the skin when coated microneedles are being used is calculated by:…”

Section: Governing Equations For Drug Transport In Skin 165mentioning

confidence: 99%

Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability

Davidson

Al-Qallaf

Das

2008

Chemical Engineering Research and Design

133

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can potentially allow the transdermal delivery of many medicaments including large macromolecules that typically cannot diffuse through the skin. This paper addresses the use of microneedles coated with a drug solution film. In particular, we identify how the geometries of various microneedles affect the drug permeability in skin. Effective skin permeability is calculated for a range of microneedle shapes and dimensions in order to identify the most 20 efficient geometry. To calculate effective permeability (P eff ), the effective skin thickness (H eff ) is calculated. These are then plotted for insulin as a model drug to see how various microneedle parameters affect the profiles of both H eff and P eff . It is found that the depth of penetration from the microneedle array is the most important factor in determining P eff , followed by the microneedle spacings. Other parameters such as microneedle diameter and 25 coating depth are less significant.

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Section: Governing Equations For Drug Transport In Skin 165mentioning

confidence: 99%

Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability

Davidson

Al-Qallaf

Das

2008

Chemical Engineering Research and Design

133

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“…Metals traditionally used for MN fabrication consist of stainless steel, nickel coated in gold, titanium, platinum and palladium (Martanto et al, 2004;Wang et al, 2006;Mansoor et al, 2013). Although numerous journal papers have been published on the use of silicon as a primary substituent of MN DOI: 10.3109/10717544.2014.986309 formulation, the material itself has yet to be FDA approved (Park et al, 2005).…”

Section: Trends In Mn Dd Methodsmentioning

confidence: 99%

“…They also differ in shape, ranging from square, circular, flat tipped, sharp tipped, etc. (Henry et al, 1998;Park et al, 2005;Gupta et al, 2009;Swain et al, 2011;Kommareddy et al, 2013;Mansoor et al, 2013;Torrisi et al, 2013;Pierre & Rossetti, 2014). There has been a lot of research conducted on MNs for the delivery and monitoring of various drugs such as glucose control for diabetics (Ito et al, 2006;Nordquist et al, 2007;Ainslie & Desai, 2008;El-Laboudi et al, 2013;Taylor & Sahota, 2013;Ita, 2014), Alzheimer's disease (Wei-Ze et al, 2010), anticancer (Fang et al, 2008) and other conditions (Ezan, 2013).…”

Section: Trends In Mn Dd Methodsmentioning

confidence: 99%

“…There have been multiple studies conducted to optimize the delivery of drugs using MNs with numerous methods to fabricate them. Park et al (2005) used biodegradable polymer MNs with sharp tips to overcome problems associated with safety and disposal. They found that the use of biodegradable MNs increased skin permeability by three fold, which increase the delivery of drugs transdermally.…”

Section: Trends In Mn Dd Methodsmentioning

confidence: 99%

“…The invention of the MN can overcome this factor as the needles bypass the SC layer, which is the rate dependent layer and can allow large molecular weight proteins to pass into the blood stream (Prausnitz, 2004). A well-known method to quantify the drug release through skin is the use of Franz diffusion cells and therefore have been used in literature extensively to calculate the permeability of skin (Henry et al, 1998;Park et al, 2005;Singh & Banga, 2013).…”

Section: Increasing Permeability Of Skinmentioning

confidence: 99%

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Microneedles for drug delivery: trends and progress

2014

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In recent years, there has been a surge in the research and development of microneedles (MNs), a transdermal delivery system that combines the technology of transdermal patches and hypodermic needles. The needles are in the hundreds of micron length range and therefore allow relatively little or no pain. For example, biodegradable MNs have been researched in the literature and have several advantages compared with solid or hollow MNs, as they produce non-sharp waste and can be designed to allow rapid or slow release of drugs. However, they also pose a disadvantage as successful insertion into the stratum corneum layer of the skin relies on sufficient mechanical strength of the biodegradable material. This review looks at the various technologies developed in MN research and shows the rapidly growing numbers of research papers and patent publications since the first invention of MNs (using time series statistical analysis). This provides the research and industry communities a valuable synopsis of the trends and progress being made in this field.

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Routes of Delivery for Biological Drug Products

Irvine¹,

Su²,

Kwong³

2013

Pharmaceutical Sciences Encyclopedia

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Unlike conventional small‐molecule drugs, many of which can be formulated effectively with excipients to avoid degradation in the stomach and which exhibit reasonably efficient uptake through the gastrointestinal tract, biological drugs may exhibit lower stability and a greater sensitivity to enzymatic degradation, making oral delivery problematic. Thus, the majority of biologics are currently administered through subcutaneous/intramuscular injection or via intravenous infusion. Recent advances in delivery of traditional biologics include methods to increase the acceptable volume of drug solutions that can be administered subcutaneously.In addition, a number of alternative routes of administration for biologic drug products are being intensively investigated at the preclinical and clinical stages, such as intranasal, pulmonary, transcutaneous, and other routes, with some first examples of products recently licensed.This chapter will review current methods in use for marketed biologics and advanced approaches undergoing clinical testing.

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Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery

Cited by 802 publications

References 27 publications

Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability

Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability

Microneedles for drug delivery: trends and progress

Routes of Delivery for Biological Drug Products

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