Biodegradable Polymer-Based Drug-Delivery Systems for Ocular Diseases

Tsung, Ta-Hsin; Tsai, Yu-Chien; Lee, Hsin-Pei; Chen, Yi-Hao; Lu, Da-Wen

doi:10.3390/ijms241612976

Cited by 12 publications

(6 citation statements)

References 242 publications

(273 reference statements)

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“…A thermosensitive hydrogel made of quaternary chitosan and glycerophosphate (HACC/GP) has also been used to treat SCI, along with adenovirus and MSCs that carried the neurotrophic factor gene for glial cell-derived neurotrophic factor (GDNF) (Ad-rGDNF) ( Tsung et al, 2023 ). The survival and growth of MSCs can be supported by human astrocyte-conditioned medium (HACC) within the scaffold material.…”

Section: Combined Application Of Biomaterialsmentioning

confidence: 99%

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Gao,

Wang,

et al. 2024

Front. Cell. Neurosci.

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Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, and autonomic function. There is currently no effective treatment for SCI. SCI occurs within three temporal periods: acute, subacute, and chronic. In each period there are different alterations in the cells, inflammatory factors, and signaling pathways within the spinal cord. Many biomaterials have been investigated in the treatment of SCI, including hydrogels and fiber scaffolds, and some progress has been made in the treatment of SCI using multiple materials. However, there are limitations when using individual biomaterials in SCI treatment, and these limitations can be significantly improved by combining treatments with stem cells. In order to better understand SCI and to investigate new strategies for its treatment, several combination therapies that include materials combined with cells, drugs, cytokines, etc. are summarized in the current review.

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Section: Combined Application Of Biomaterialsmentioning

confidence: 99%

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Gao,

Wang,

et al. 2024

Front. Cell. Neurosci.

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“…Hydrophobic components include biodegradable polyesters and amino acids like polylactide (PLLA), polyglycolide (PGA), polycaprolactone (PCL), polylactic glycolate (PLGA), polyaspartic acid (PAsp), polybenzylaspartic acid (PBLA), and polyglutamic acid (PGlu). Polymer nanomicelles can be categorized into three types based on the arrangement of amphiphilic molecules: amphiphilic block copolymers, graft polymer micelles, and amphiphilic random copolymers [40][41][42].…”

Section: Nanotechnology-based Ocular Drug Delivery Systemsmentioning

confidence: 99%

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Liu,

Chen,

2023

IJMS

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Ocular diseases profoundly impact patients’ vision and overall quality of life globally. However, effective ocular drug delivery presents formidable challenges within clinical pharmacology and biomaterial science, primarily due to the intricate anatomical and physiological barriers unique to the eye. In this comprehensive review, we aim to shed light on the anatomical and physiological features of the eye, emphasizing the natural barriers it presents to drug administration. Our goal is to provide a thorough overview of various characteristics inherent to each nano-based drug delivery system. These encompass nanomicelles, nanoparticles, nanosuspensions, nanoemulsions, microemulsions, nanofibers, dendrimers, liposomes, niosomes, nanowafers, contact lenses, hydrogels, microneedles, and innovative gene therapy approaches employing nano-based ocular delivery techniques. We delve into the biology and methodology of these systems, introducing their clinical applications over the past decade. Furthermore, we discuss the advantages and challenges illuminated by recent studies. While nano-based drug delivery systems for ophthalmic formulations are gaining increasing attention, further research is imperative to address potential safety and toxicity concerns.

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“…Chemical identifications of PLGAs were carried out in terms of an explanation of the NMR and IR spectra, and determination of molecular weight, thermal properties, and morphologic properties. 1 H NMR and 13 C NMR spectra were followed on a Bruker Avance 300 MHz spectroscopy (Bruker Daltonics, Billerica, MA, USA), and reported in CDCl 3 . 1 H NMR and 13 C NMR chemical shifts (δ) were reported in parts per million relative to either tetramethylsilane (TMS) (δ = 0 ppm) as an internal standard or the residual solvent peak as follows: CDCl 3 = 7.26 ( 1 H NMR), CDCl 3 = 77.16 ( 13 C NMR).…”

Section: Generalmentioning

confidence: 99%

“…Since PLGA was resynthesized, the identification of the chemistry of PLGA is repeated. PLGA: white solid, 1 H NMR (300 MHz, CDCl 3 ) δ H 5.23-5.15 (-CH-), 4.91-4.60 (-CH 2 -), 1.56 (-CH 3 ), 13 C NMR (125 MHz, CDCl 3 ) δ C 175.13 (CO), 169.38 (CO), 71.46 (-CH-), 60.78 (-CH 2 -), 16.75 (-CH 3 ), FT-IR (neat, cm −1 ) 3003.58 (υCH 3 ), 2925.08 (υCH 3 ), 1750.72 (υC=O), 1445.06 (δCH 2 ), 1385.24 (δCH 3 ), 1249.21 (τCH 2 ), 1087.55 (υC-O-C), GPC (THF, RI): M n = 3000 g/mol, Ð = 3.438.…”

Section: Synthesis Of Poly(lactic-co-glycolic Acid) (Plga)mentioning

confidence: 99%

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Synthesis of L-Ornithine- and L-Glutamine-Linked PLGAs as Biodegradable Polymers

Taşkor Önel

2023

Polymers

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L-ornithine and L-glutamine are amino acids used for ammonia and nitrogen transport in the human body. Novel biodegradable synthetic poly(lactic-co-glycolic acid) derivatives were synthesized via conjugation with L-ornithine or L-glutamine, which were selected due to their biological importance. L-ornithine or L-glutamine was integrated into a PLGA polymer with EDC coupling reactions as a structure developer after the synthesis of PLGA via the polycondensation and ring-opening polymerization of lactide and glycolide. The chemical, thermal, and degradation property–structure relationships of PLGA, PLGA-L-ornithine, and PLGA-L-glutamine were identified. The conjugation between PLGA and the amino acid was confirmed through observation of an increase in the number of carbonyl carbons in the range of 170–160 ppm in the 13C NMR spectrum and the signal of the amide carbonyl vibration at about 1698 cm−1 in the FTIR spectrum. The developed PLGA-L-ornithine and PLGA-L-glutamine derivatives were thermally stable and energetic materials. In addition, PLGA-L-ornithine and PLGA-L-glutamine, with their unique hydrophilic properties, had faster degradation times than PLGA in terms of surface-type erosion, which covers their requirements. L-ornithine- and L-glutamine-linked PLGAs are potential candidates for development into biodegradable PLGA-derived biopolymers that can be used as raw materials for biomaterials.

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Biodegradable Polymer-Based Drug-Delivery Systems for Ocular Diseases

Cited by 12 publications

References 242 publications

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Synthesis of L-Ornithine- and L-Glutamine-Linked PLGAs as Biodegradable Polymers

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