Biodegradable polylactide and thermoplastic starch blends as drug release device – mass transfer study

Abstract

Four different compositions of polylactide/thermoplastic starch blends (PLA/TPS blends) for application as drug carriers were examined. Initially, using cyanocobalamin (1.355 kDa) as a model compound, the blend with the highest starch content (wt. 60%) was selected for further research of mass transfer phenomenon. In this case, different concentrations of acetaminophen (0.151 kDa), doxorubicin hydrochloride (0.580 kDa) and cyanocobalamin (1.355 kDa) were used for determination of particular releasing profi les. Besides from the comparative analysis of obtained results, the values of the overall mass transfer coeffi cient (K) were calculated for each of tested drug molecules. Depending on the size and properties of used compound, determined values of the coeffi cient range from 10 -11 to 10 -13 m/s. Based on these outcomes, it could be stated that PLA/TPS blend selected in preliminary research, seems to be preferred material for fabrication of long-term drug delivery systems, which could be successfully applied for example in anti-cancer therapy.

Effect of Electron-Beam Radiation and Other Sterilization Techniques on Structural, Mechanical and Microbiological Properties of Thermoplastic Starch Blend

“…TPS can be obtained in the course of destruction of the crystalline phase of the native starch by thermal and mechanical methods using a plasticizer, such as water, glycerol, urea or sorbitol, which reduces the glass transition temperature and melting point of starch [10]. After the modification, starch can be processed by standard methods used for thermoplastic polymers such as extrusion, injection molding, thermoforming and hotpressing [11]. However, high hydrophilicity, low degradation temperatures and poor mechanical properties of TPS give a limitation for its various industrial applications [12].…”

“…The solution to this problem can be blending of starch with more hydrophobic biodegradable polyesters. The most studied starch blends are those based on poly(butylene adipate-co-terephthalate), PBAT [13,14], poly(ε-caprolactone), PCL [15,16], polylactide, PLA [11] and poly(butylene succinate), PBS [17,18]. In all cases, the introduction of TPS into polyester matrix caused significant reduction in mechanical properties and several attempts were made in order to improve the miscibility with biodegradable polyesters.…”

The effectiveness of fiber-reinforced natural composites compared to the elastomer materials produced from nonrenewable resources in vibration transmission suppression

“…There were many attempts to improve its properties to be more competitive with more flexible polymers (polyethylene or polyethylene terephthalate) by blending with biodegradable polymers or copolymerization with other polyesters. [25][26][27][28][29] One of the economically viable options is adding plasticizer which can greatly improve the mechanical properties of the end material and provide a time stable biodegradable blend that can later be used to produce other composites with properties tailored for specific application. 27 Furthermore, with increased environmental consciousness of the society and with the reducing feedstock of nonrenewable resources, it has come for natural biodegradable composites to broaden their application range, including vibration dampening.…”

Development and Validation of a Virtual Gelatin Model Using Molecular Modeling Computational Tools

“…are huge group of multipurpose organic compounds of diverse functional properties, based on the specificity of the reactive groups present in their structure. This all contributes to the fact that renewable polymeric biomaterials are currently being successfully utilized in a variety of medical [8,9,10], pharmaceutical [11,12,13], food processing [3,14,15,16,17], sensing [18,19,20,21], agricultural [22,23], environmental protection [24,25,26] and other biotechnological applications.…”