Biodegradable polyanhydride devices of cefazolin sodium, bupivacaine, and taxol for local drug delivery: preparation, and kinetics and mechanism of in vitro release

Park, Eun-Seok; Maniar, Manoj; Shah, Jaymin

doi:10.1016/s0168-3659(97)00223-x

Cited by 98 publications

(67 citation statements)

References 12 publications

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“…Local anesthetics such as bupivacaine was formulated in the cubic phase gel and applied at the wound site to provide sustained release of the drug (22). To the best of our knowledge, there is no published study to date reporting the influence of cubic phase gel properties on the release of entrapped capsaicin for the topical application.…”

Section: Introductionmentioning

confidence: 99%

Design and In Vitro Evaluation of Capsaicin Transdermal Controlled Release Cubic Phase Gels

et al. 2010

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Abstract. The purpose of this study was to design and investigate the transdermal controlled release cubic phase gels containing capsaicin using glycerol monooleate (MO), propylene glycol (1,2-propanediol, PG), and water. Three types of cubic phase gels were designed based on the ternary phase diagram of the MO-PG-water system, and their internal structures were confirmed by polarizing light microscopy (PLM) and small-angle X-ray scattering (SAXS). Release results showed the cubic phase gels could provide a sustained system for capsaicin, while the initial water content in the gels was the major factor affecting the release rate. Release kinetics was determined to fit Higuchi's square-root equation indicating that the release was under diffusion control. The calculated diffusion exponent showed the release from cubic phase gels was anomalous transport. The unique structure of the cubic phases, capsaicin distributed in the lipid bilayers, and cubic phase gel swelling contributed to the release mechanism. The cubic phase gel may be an interesting application for transdermal delivery system of capsaicin in alleviating the post-incision pain.

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Section: Introductionmentioning

confidence: 99%

Design and In Vitro Evaluation of Capsaicin Transdermal Controlled Release Cubic Phase Gels

et al. 2010

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“…Thus for example, the release ofpnitroaniline (PNA), which is mainly dissolved in the slowly eroding phase (CPP or CPH), mimics the erosion profile of that phase once the fast eroding phase (SA) is dissolved . Qualitatively similar inferences can be drawn by observation of release data of other compounds loaded into copolymers of the same family Olivi et al, 1996;Kuntz and Saltzman, 1997;Park et al, 1998).…”

Section: 6introductionsupporting

confidence: 56%

“…Dissolution time steps were then iterated to compute the temporal evolution of the erosion front and drug release. The resulting profiles showed almost linear fractional mass release profiles in contrast with the sigmoidal release that many experimental data show Park et al, 1998;). …”

Section: Previous Modelsmentioning

confidence: 84%

Engineering bioerodible polymers with tailored micro/nanostructure for vaccine delivery

Kipper

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“…Nevertheless only poly(sebacic anhydride) and its derivations are applied in the drug-controlled release system, including poly[(1,3-bis(p-carboxyphenoxy)propane)-co-(sebacic anhydride) (P(CPP-SA)) [20], poly[(1,6-bis-p-carboxyphenoxy hexane)-co-(sebacic anhydride)] (P(CPH-SA)) [21,22], poly[(erucic acid dimer)-co-(sebacic anhydride)] (P(EAD-SA)) [23,24] and poly[(fumaric acid)-co-(sebacic anhydride)] (P(FA-SA)) [25,26], etc. The Food and Drug Administration (FDA) has approved the use of P(CPP-SA) to deliver the chemotherapeutic agent BCNU for the treatment of brain cancer [27].…”

Section: Introductionmentioning

confidence: 99%

Characterization and in vitro degradation of poly(octadecanoic anhydride)

Dong

Zhang

Jiang

et al. 2007

J Mater Sci: Mater Med

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Poly(octadecanoic anhydride) (POA) has been prepared by melt polycondensation of octadecanoic diacid. POA was characterized by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WAXD). The results of in vitro degradation and SEM micrographs show that the erosion process of POA is neither bulk nor perfect surface erosion but rather has elements of both in phosphate buffer at 37°C. The moving erosion front is characteristic of surface erosion whereas the remaining porous shell stems from bulk erosion. While a significant special degradation property of POA is that POA presents a very slow degradation rate in acidic condition (pH 5.98), only 1.64% weight loss for 20 days, and it completely degrades after 18 days in basic buffer (pH 7.4). Comparing with poly(sebacic anhydride) (PSA), POA has the higher crystallization degree, and the slower hydrolytic rate.

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Biodegradable polyanhydride devices of cefazolin sodium, bupivacaine, and taxol for local drug delivery: preparation, and kinetics and mechanism of in vitro release

Cited by 98 publications

References 12 publications

Design and In Vitro Evaluation of Capsaicin Transdermal Controlled Release Cubic Phase Gels

Design and In Vitro Evaluation of Capsaicin Transdermal Controlled Release Cubic Phase Gels

Engineering bioerodible polymers with tailored micro/nanostructure for vaccine delivery

Characterization and in vitro degradation of poly(octadecanoic anhydride)

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