Biodegradable poly(urethane-urea-amide): Synthesis, characterization and mechanical studies

Abstract

Biodegradable polyurethane with excellent mechanical property finds a lot of applications in the biomedical field. In this study, multi block copolymer poly(urethane-urea-amide) (PUUA) is prepared using polyethylene oxide, 1,6-hexamethylene diisocyanate and diamide (N1, N4-bis(6-aminohexyl)benzene-1,4-dicarboxamide (6T6) or N 1, N 6-bis(6-aminohexyl)hexanediamide (6A6)) by a method of solution/melt polymerization techniques. The polymer formation is confirmed by the 1H NMR spectroscopic method. Other techniques such as viscosity measurements, FT-IR, DSC, TGA, and biodegradability are used to characterize the synthesized copolymers. The hard segment crystallinity is an analyzed by FT-IR spectroscopy, it revealed that the 6T6 based polymer showed 70% of crystallinity. The synthesized copolymer shows three transitions in the DSC curve. The melting enthalpy of the hard segment depends on the amide unit employed in the polymerization process. These materials are fast crystallizing due to low under cooling value. This material has a very high thermal stability and stable up to 400°C. Tensile test confirms the strain induced crystallization of hard segment occurred in the PUUA. The biodegradability of the polymer depends on the pH and chain extenders. This type of materials can be a good candidate for tissue engineering application.

Polyurethane-urea-amide-based triblock copolymer contains functionalized polystyrene: Synthesis, characterization and solvent resistivity study

“…[1][2][3] and present of different type of soft and hard segments is responsible for the PU chain flexibility which is essential for the above said applications. [4][5][6][7] To date, thermoplastic polymer is being synthesized by varying hard and soft segments for different applications. 6,[8][9][10] There hasn't been much research into thermoplastic polyurethane (TPU) with various functional groups, and the existence of a functional group in TPU can decide its applications and uses.…”