Biodegradable Poly(ethylene carbonate) Nanoparticles as a Promising Drug Delivery System with “Stealth” Potential

Bege, Nadja; Renette, Thomas; Jansch, Mirko; Reul, Regina; Merkel, Olivia M.; Petersen, Holger; Curdy, Catherine; Müller, Rainer H.; Kissel, Thomas

doi:10.1002/mabi.201000496

Cited by 20 publications

(10 citation statements)

References 39 publications

(56 reference statements)

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“…Despite the encapsulation of the anti‐cancer drug PTX, the size of the NPs remained constant which is in line with lipophilic dye loaded NPs reported in a former study 21. Unloaded PEC NPs yielded sizes of 214 ± 6 nm (PDI = 0.05 ± 0.02).…”

Section: Resultssupporting

confidence: 88%

“…PEC NPs were prepared using a modified solvent displacement technique 21, 33, 34. Briefly, PEC was dissolved in acetonitrile at a concentration of 10 mg · mL −1 .…”

Section: Methodsmentioning

confidence: 99%

“…In previous studies, we demonstrated that NPs of poly(ethylene carbonate) (PEC) satisfy the requirements concerning surface, size and charge properties 21. Due to the hydrophilic surface properties of PEC,22 a low amount of serum protein adsorption combined with a nearly neutral zeta‐potential were observed.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the hydrophilic surface properties of PEC,22 a low amount of serum protein adsorption combined with a nearly neutral zeta‐potential were observed. PEC NPs escaped uptake by cells of the mononuclear phagocytic system (MPS) under in vitro conditions 21. Based on these “stealth” properties, PEC NPs were assumed to be a promising drug delivery system for passive tumor targeting in vivo.…”

Section: Introductionmentioning

confidence: 99%

“…To verify the hypothesized prolonged circulation time, radiolabeled PEC NPs were administered to mice intravenously and were compared with PLGA, the commonly used standard for polymeric NPs. Due to the low amount of adsorbed plasma proteins on the PEC NP surface, as shown in vitro, the applicable size of 200 nm and the nearly neutral zeta potential,21 this carrier system should reduce recognition by cells of the MPS. The suitability of PTX loaded PEC NPs as a cytostatic drug carrier system was studied in an in vivo tumor model.…”

Section: Introductionmentioning

confidence: 99%

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Poly(ethylene carbonate) Nanoparticles as Carrier System for Chemotherapy Showing Prolonged in vivo Circulation and Anti‐Tumor Efficacy

Renette

Librizzi

Endres

et al. 2012

Macromolecular Bioscience

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The aim of this study is to investigate the feasibility and efficacy of PEC nanoparticles as delivery system for cancer chemotherapy. Assembly of paclitaxel‐loaded nanoparticles with high loading efficiency and narrow‐size distribution is successful. For non‐invasive in vivo tracing, nanoparticle blends of chelator bearing poly(lactide) with PEC and PLGA are successfully prepared. Pharmacokinetic studies in mice reveal a twofold higher circulation time of PEC as compared to PLGA. A tumor model shows an accumulation of PEC NPs in cancerous tissue and a higher anti‐tumor efficiency compared to the standard Taxol™, which is reflected in a significantly slower tumor growth compared to the NaCl control group.

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Section: Resultssupporting

confidence: 88%

“…PEC NPs were prepared using a modified solvent displacement technique 21, 33, 34. Briefly, PEC was dissolved in acetonitrile at a concentration of 10 mg · mL −1 .…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Poly(ethylene carbonate) Nanoparticles as Carrier System for Chemotherapy Showing Prolonged in vivo Circulation and Anti‐Tumor Efficacy

Renette

Librizzi

Endres

et al. 2012

Macromolecular Bioscience

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Aliphatic Poly(carbonate)s: Syntheses, Structures, and Applications

Hu¹,

Zhang²,

Zhang³

2022

Macromolecular Engineering

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Aliphatic poly(carbonate) (APC) is a kind of polymer with repeated units of [ROC(=O)O] n , where R is an aliphatic linker. This article introduces three universal synthetic methods to APCs, including alternating copolymerization of carbon dioxide (CO 2 ) with epoxides, condensation of dialkyl carbonates with diols, condensation of CO 2 and diols (dihalides), and ring‐opening polymerization of the cyclic carbonates. The accessible catalyst systems for the copolymerization of CO 2 with epoxides are intensively discussed to understand the control of the microstructures of CO 2 ‐based APCs. Special attention is paid to the metal‐free catalytic synthesis of APCs. Based on the catalysts for CO 2 ‐based copolymers, a variety of di‐, tri‐, and multi‐block copolymers containing APC block are presented with the discussion of their syntheses, structures, and properties. The thermal, mechanical, biodegradable, and conductive properties of these APCs are described in detail with respect to the application.

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Design of polyethylene glycol–polyethylenimine nanocomplexes as non‐viral carriers: mir‐150 delivery to chronic myeloid leukemia cells

Avcı

Özcan

Balci

et al. 2013

Cell Biology International

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MicroRNAs (miRNAs) are acknowledged as indispensable regulators relevant in many biological processes, and they have been pioneered as therapeutic targets for curing disease. miRNAs are single-stranded, small (19-22 nt) regulatory non-coding RNAs whose deregulation of expression triggers human cancers, including leukemias, mainly through dysregulation of expression of leukemia genes. miRNAs can function as tumour suppressors (suppressing malignant potential) or oncogenes (activating malignant potential) like actors of complex diseases. To address the issue of overcoming instability and low transfection efficiency in vitro, the polyethylene glycol-polyethyleneimine (PEG-PEI) nanoparticle was used as non-viral vector carrier for miR-150 transfection, which is downregulated in chronic myeloid leukemia. PEG-PEI [PEG(550)3 -g-PEI(1800) ]/miRNA nanocomplexes were synthesised and characterised by particle size distribution (PSD), polydispersity index (PDI) and zeta potential, surface charge, their cytotoxicity, and transfection efficiency. Interaction with human leukemia cells (K-562 and KU812) and control cells NCI-BL2347 with them has been investigated. The transfection efficiency of PEG-PEI/miRNA at N/P 26 rose 6.7-fold above the control by qRT-PCR. The size of homogenous nanocomplexes (PBI < 0.5) was 160.8 ± 11 nm. The data indicate that PEG-PEI may be an encouraging non-viral carrier for altering miRNA expression in the treatment of chronic myeloid leukemia, with many advantages such as relatively high miRNA transfection efficiency and low cytotoxicity.

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Biodegradable Poly(ethylene carbonate) Nanoparticles as a Promising Drug Delivery System with “Stealth” Potential

Cited by 20 publications

References 39 publications

Poly(ethylene carbonate) Nanoparticles as Carrier System for Chemotherapy Showing Prolonged in vivo Circulation and Anti‐Tumor Efficacy

Poly(ethylene carbonate) Nanoparticles as Carrier System for Chemotherapy Showing Prolonged in vivo Circulation and Anti‐Tumor Efficacy

Aliphatic Poly(carbonate)s: Syntheses, Structures, and Applications

Design of polyethylene glycol–polyethylenimine nanocomplexes as non‐viral carriers: mir‐150 delivery to chronic myeloid leukemia cells

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