Biodegradable phytic acid conversion coatings on magnesium alloy for temporary orthopedic implant: A review

Xu, Yingchao; Guo, Yunting; Li, Guangyu; Lian, Jianshe

doi:10.1016/j.porgcoat.2022.106920

Cited by 6 publications

(3 citation statements)

References 130 publications

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“…It contains 12 OH and six phosphate carboxyl groups. 37 The active group in PA will chelate with the dissolved Mg 2+ to form a stable insoluble complex, which will be deposited on the surface of Mg alloys as a protective barrier against corrosive ions invasion. The primary reaction of Mg in PA solutions can be characterized as 37,58 :…”

Section: Slow Strain Rate Tensile (Ssrt) Testsmentioning

confidence: 99%

“…It would not deteriorate the mechanical performance of the Mg matrix, and effectively mitigate the formation of micro-galvanic cells, as the colloidal properties of the PA-metal complex. 37,38 A conversion film with micro-defects on a Mg alloy was prepared using PA treatment. Therefore, the aim of this work is to elucidate the key inhibition mechanism of biological media on the SCC behavior of biomedical Mg alloy, by weakening the effect of micro-galvanic corrosion and highlighting the SCC initiation process.…”

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confidence: 99%

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Inhibiting stress corrosion cracking of a prefabricated surface‐defective magnesium alloy thanks to biological organic components

Chen,

Li,

et al. 2024

Fatigue Fract Eng Mat Struct

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Biomedical magnesium (Mg) alloys remain a challenge for their mainstream application, because the combination of bio‐mechanical stress and corrosive physiological environment leading to stress corrosion cracking (SCC). It is crucial to avoid the sudden brittle fracture of Mg alloys in vivo for predicting their service duration. However, the key factors, such as surface or physiological environment features, determining the origination or propagation of SCC behavior are still unclear. In the present study, a prefabricated surface defects coating was prepared by the phytic acid (PA, C6H18O24P6) conversion treatment. Four mimicking physiological media were used, ranging from simple to equivalent (Dulbecco's Modified Eagle Medium and Protein [DMEM+Pro]). The results showed that the PA film with numerous micro‐cracks provided limited protective ability in synthetic biological media. A striking finding was determined that although initial high corrosion rate of samples in DMEM+Pro led to an increased SCC nucleation, significant ductile fracture with elongation to failure (14.86%) was observed. Combined with the fracture features, the adsorption or deposition of biological composition into the tunnel of SCC cracks significantly inhibited the hydrogen embrittlement (HE) behavior. These results indicate that preventing the propagation of SCC crack by biological composition, rather than nucleation, plays a key role in avoiding the sudden fracture of Mg alloys. It provides a novel perspective to determine the non‐brittle fracture of Mg alloys for biomedical applications.

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Section: Slow Strain Rate Tensile (Ssrt) Testsmentioning

confidence: 99%

mentioning

confidence: 99%

Inhibiting stress corrosion cracking of a prefabricated surface‐defective magnesium alloy thanks to biological organic components

Chen,

Li,

et al. 2024

Fatigue Fract Eng Mat Struct

View full text Add to dashboard Cite

show abstract

“…[4][5][6][7][8] It has broad application space and development prospects in fields such as aerospace, transportation, electronic devices, and biomaterial. [9][10][11][12][13] Hence, Mg and its alloys are expected to become alternative materials for other traditional metals.…”

Section: Introductionmentioning

confidence: 99%

Magnesium Alloy Composite Water‐Repellent Surface with Durable Corrosion Resistance and Self‐Cleaning Behavior

Cai,

Xu,

et al. 2024

Adv Eng Mater

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Magnesium (Mg) alloys have poor corrosion resistance, higher requirements for corrosion resistance of the coating, and the changes in the environment in the actual application are complicated and diverse. Therefore, it is urgent to develop bio‐inspired water‐repellent surfaces (WRSs) with long‐lasting corrosion resistance and multiple excellent properties for Mg alloys. In this study, a composite water‐repellent surface (CWRS) with long‐lasting corrosion resistance and self‐cleaning behavior is prepared by combining laser processing, hydrothermal treatment, and immersion method on the Mg alloy surface. The effect of ambient temperature changes on the wettability and corrosion resistance of the CWRS is investigated. The experimental results showed that a uniform and dense CWRS with a film thickness of 36 μm could be prepared on the Mg alloy surface at an ambient temperature of 180 °C, demonstrating excellent corrosion resistance and self‐cleaning behavior. In addition, in the harsh salt spray test, it is found that even if the superhydrophobicity of the CWRS was lost, the surface still has good corrosion resistance. Multifunctional CWRSs have become a research hotspot, and it is of great significance to promote the application of Mg alloys in actual working conditions.

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Sodium Phytate‐Incorporated Gelatin‐Silicate Nanoplatelet Composites for Enhanced Cohesion and Hemostatic Function of Shear‐Thinning Biomaterials

Zehtabi

Montazerian

Haghniaz

et al. 2022

Macromolecular Bioscience

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Shear‐thinning biomaterials (STBs) based on gelatin‐silicate nanoplatelets (SNs) are emerging as an alternative to conventional coiling and clipping techniques in the treatment of vascular anomalies. Improvements in the cohesion of STB hydrogels pave the way toward their translational application in minimally invasive therapies such as endovascular embolization repair. In the present study, sodium phytate (Phyt) additives are used to tune the electrostatic network of SNs‐gelatin STBs, thereby promoting their mechanical integrity and facilitating injectability through standard catheters. We show that an optimized amount of Phyt enhances storage modulus by approximately one order of magnitude and reduces injection force by ≈58% without compromising biocompatibility and hydrogel wet stability. The Phyt additives are found to decrease the immune responses induced by SNs. In vitro embolization experiments suggest a significantly lower rate of failure in Phyt‐incorporated STBs than in control groups. Furthermore, the addition of Phyt leads to accelerated blood coagulation (reduces clotting time by ≈45% compared to controls) due to the contributions of negatively charged phosphate groups, which aid in the prolonged durability of STB in coagulopathic patients. Therefore, the proposed approach is an effective method for the design of robust and injectable STBs for minimally invasive treatment of vascular malformations.

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Biodegradable phytic acid conversion coatings on magnesium alloy for temporary orthopedic implant: A review

Cited by 6 publications

References 130 publications

Inhibiting stress corrosion cracking of a prefabricated surface‐defective magnesium alloy thanks to biological organic components

Inhibiting stress corrosion cracking of a prefabricated surface‐defective magnesium alloy thanks to biological organic components

Magnesium Alloy Composite Water‐Repellent Surface with Durable Corrosion Resistance and Self‐Cleaning Behavior

Sodium Phytate‐Incorporated Gelatin‐Silicate Nanoplatelet Composites for Enhanced Cohesion and Hemostatic Function of Shear‐Thinning Biomaterials

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