Biodegradable pH-sensitive polyurethane micelles with different polyethylene glycol (PEG) locations for anti-cancer drug carrier applications

Yao, Yongchao; Xu, Duanyang; Liu, Chang; Guan, Yong; Jiya, Zhang; Su, Yuling; Zhao, Lili; Meng, Fancui; Luo, Jianbin

doi:10.1039/c6ra20613a

Cited by 31 publications

(18 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The precipitant was dissolved in DMAc and casted into PTFE Petri dish which was instantly dried in an vacuum oven at 40 C, 60 C and 80 C for 24 h, respectively, resulting PU-GAP. 39 2.3 Surface modication of PU-GAP lm by click chemistry 2.3.1 Synthesis of mPEG-alkyne. In a thoroughly dried Schlenk ask, NaH (10 mmol, 0.24 g) was suspended in 100 mL anhydrous DCM, stirring for 30 min.…”

Section: Synthesis Of Polyurethane With Pendant Azide Groupsmentioning

confidence: 99%

Synthesis of polyurethanes with pendant azide groups attached on the soft segments and the surface modification with mPEG by click chemistry for antifouling applications

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Synthesis Of Polyurethane With Pendant Azide Groupsmentioning

confidence: 99%

Synthesis of polyurethanes with pendant azide groups attached on the soft segments and the surface modification with mPEG by click chemistry for antifouling applications

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…The synthesis route to fluorinated PUs is shown in Scheme . The PU chain extender with pedant fluorinated alkyl, denoted as EF, was synthesized first by reacting perfluorooctanoic acid and 2‐amino‐1,3‐propanediol using the DCC condensation method.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and antifouling activities of fluorinated polyurethanes

Qiao

Yan

et al. 2019

Polymer International

Self Cite

View full text Add to dashboard Cite

A series of fluorinated polyurethanes (FPUs) with various contents of fluorinated chain extender (EF) and the same amount of poly(oxytetramethylene glycol) and diphenylmethanediisocyanate were synthesized to explore the relationship between the surface physicochemical properties and bulk microphase separation structures of these FPUs and their antifouling activities against model bacteria and platelets. The bulk microphase separation of FPUs increased with the amount of incorporated EF. It was found that the surfaces of all FPUs were saturated by a layer of fluorocarbon chains which resulted in similar chemical composition and wetting activities for the three kinds of FPUs. The FPUs with lower or similar microphase separation compared with non-fluorinated polyurethane chain-extended with 1,4-butanediol showed similar or even increased adhesion of bacteria and platelets. Notably, FPU with a higher degree of microphase separation than non-fluorinated polyurethane displayed excellent antifouling activities against both model bacteria and blood platelets. It is therefore concluded that the increased microphase separation of the FPUs results in enhanced antifouling properties.

show abstract

“…An essential factor in terms of drug release from some carriers is the pH value of the biological environment. Y. Yao et al [ 6 ] described the preparation of some biodegradable pH-sensitive polyurethane (PU) micelles based on polyethylene glycol (PEG), which were used as carriers for the anti-cancer drug paclitaxel. They modified the polyurethane chains by using PEGylated diethanolamine as a chain extender, and the results indicated an increased cytotoxic effect against the H460 lung cancer cells compared to other PEGylated polyurethane micelles that were used as a reference.…”

Section: Introductionmentioning

confidence: 99%

A Study on the Behavior of a Polyurethane Drug Carrier in Various pH Media

et al. 2020

View full text Add to dashboard Cite

Polyurethane nano- and micro-structures have been studied intensively in the last decade as drug delivery systems for various herbal extracts as well as pure active biological substances. Their biocompatibility, haemocompatibility, safe degradation, and low-cost production are just a few advantages of these materials that were already used in numerous medical applications (catheters, surgical drapes, wound dressing). The primary purposes of this study include obtaining empty polyurethane microstructures and the assessment of their modifications in media with different pH values. A mixture of two aliphatic diisocyanates and an aqueous phase based on a polyether were used during the synthesis process. The size, homogeneity, and surface charge were studied using a Cordouan Technol. Zetasizer, while the pH measurements were conducted with a portable pH Meter Checker®, Hanna Instruments. The results showed the obtaining of an almost homogeneous sample containing microstructures with sizes ranging between 139 and 151 nm, with a pH value of approximately 6.78 and a Zeta potential of 24.6. Expected decreases in microparticles’ sizes were observed in all types of media during a 15-days experiment, but the process was accelerated by a low pH when an increase of the Zeta potential value was noticed as well. Our data provide new information about the degradation process of the polyurethane microstructures on the one hand and the drug release rate of these materials when used as drug carriers, on the other hand.

show abstract

Biodegradable pH-sensitive polyurethane micelles with different polyethylene glycol (PEG) locations for anti-cancer drug carrier applications

Abstract: Biodegradable pH sensitive polyurethane micelles with a dense brush like coating of PEG were prepared. The PTX-loaded PEG-g-PU-3 micelles exhibited potent cytotoxicity against H460 cancer cells compared to PEG-b-PU-3 and PEG-c-PU-3 micelles.

Cited by 31 publications

References 41 publications

Synthesis of polyurethanes with pendant azide groups attached on the soft segments and the surface modification with mPEG by click chemistry for antifouling applications

Synthesis of polyurethanes with pendant azide groups attached on the soft segments and the surface modification with mPEG by click chemistry for antifouling applications

Synthesis and antifouling activities of fluorinated polyurethanes

A Study on the Behavior of a Polyurethane Drug Carrier in Various pH Media

Contact Info

Product

Resources

About