Biodegradable oxygen-producing manganese-chelated metal organic frameworks for tumor-targeted synergistic chemo/photothermal/ photodynamic therapy

Feng, Lei; Chen, Mengyao; Li, Ruihao; Zhou, Lulu; Wang, Chunhui; Ye, Pingting; Hu, Xiaochun; Yang, Jingxian; Sun, Yuhua; Zhu, Zhounan; Fang, Kang; Chai, Keke; Shi, Shuo; Dong, Chunyan

doi:10.1016/j.actbio.2021.10.032

Cited by 45 publications

(31 citation statements)

References 35 publications

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“…[10][11][12][13] Nevertheless, achieving synergetic PTT/PDT effects simultaneously requires cumbersome chemical procedures or duallight irradiation. [14][15][16] Moreover, most PTT/PDT materials were prepared as particles for use, 17,18 which accumulated easily and detached from the treatment area, potentially impairing the sterilization efficiency. 19 Consequently, it is necessary for a green, facile, and available method of PTT/PDT antibacterial surfaces for a high utilization efficiency and enhanced bactericidal property.…”

Section: Introductionmentioning

confidence: 99%

Surprisingly fast assembly of the MOF film for synergetic antibacterial phototherapeutics

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Surprisingly fast assembly of the MOF film for synergetic antibacterial phototherapeutics

et al. 2022

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“…Nevertheless, the specific mechanism on the induction of the immune response by PDT needs further research. As for metal organic framework (MOF), it is a new class of porous materials and has been widely investigated as the anti-cancer drug delivery vehicle owing to its high drug-loading capacity, good biodegradability and easy functionalization ( Feng et al, 2022 ). Several studies have found that PS-based MOFs could prevent self-aggregation of PS and significantly the PDT outcomes ( Gao et al, 2020 ; Alves et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Bibliometric Analysis of Global Research on Cancer Photodynamic Therapy: Focus on Nano-Related Research

et al. 2022

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A growing body of research has illuminated that photodynamic therapy (PDT) serves as an important therapeutic strategy in oncology and has become a hot topic in recent years. Although numerous papers related to cancer PDT (CPDT) have been published, no bibliometric studies have been conducted to summarize the research landscape, and highlight the research trends and hotspots in this field. This study collected 5,804 records on CPDT published between 2000 and 2021 from Web of Science Core Collection. Bibliometric analysis and visualization were conducted using VOSviewer, CiteSpace, and one online platform. The annual publication and citation results revealed significant increasing trends over the past 22 years. China and the United States, contributing 56.24% of the total publications, were the main driving force in this field. Chinese Academy of Sciences was the most prolific institution. Photodiagnosis and Photodynamic Therapy and Photochemistry and Photobiology were the most productive and most co-cited journals, respectively. All keywords were categorized into four clusters including studies on nanomaterial technology, clinical applications, mechanism, and photosensitizers. “nanotech-based PDT” and “enhanced PDT” were current research hotspots. In addition to several nano-related topics such as “nanosphere,” “nanoparticle,” “nanomaterial,” “nanoplatform,” “nanomedicine” and “gold nanoparticle,” the following topics including “photothermal therapy,” “metal organic framework,” “checkpoint blockade,” “tumor microenvironment,” “prodrug” also deserve further attention in the near future.

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“…The FA-PPSM nanocomposites exhibited excellent antitumor efficacy in Eca-109 tumor-bearing mice under 650 and 808 nm laser irradiation (Figure b). In 2021, we constructed a biodegradable oxygen-generating Mn-based nanoplatform (Ini@PM-HP) . By chelating with TCPP, Mn ions were doped into PCN-224 (named PM).…”

Section: Application For Ros-mediated Tumor Therapymentioning

confidence: 99%

“…As shown in Figure 2, Mn-based nanostructures can be mainly divided into the following three types: MONs and their hybrid structures, Mn-sealed metal− organic frameworks (MOFs) materials, and other structures. These Mn-based nanostructures are mainly obtained by commonly used methods, such as thermal decomposition method, 28 water/solvothermal method, 29 permanganate reduction method, 30 and exfoliation strategy. 31 Manganese Oxides and Their Hybrid Nanostructures.…”

Section: ■ Structures Of Mn-based Nanocarriersmentioning

confidence: 99%

An Overview of Recent Advancements on Manganese-Based Nanostructures and Their Application for ROS-Mediated Tumor Therapy

Chen

Dong

Shi

2022

ACS Materials Lett.

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To date, cancer remains one of the most lethal diseases that threatens public safety. High concentrations of reactive oxygen species (ROS) can directly induce cell apoptosis and necrosis, so it is an effective strategy to increase the ROS content in tumor cells. In recent years, ROS-mediated cancer therapy has been extensively studied. As an important transition-metal element, Mn plays a key role in biological processes. With the rapid development of nanotechnology and oncology, Mn-based materials have been widely used in ROS-mediated cancer therapy as an ideal integrated nanoplatform. This review first summarizes the research progress of Mn-based nanomaterials (NMs), including their structures and main synthesis methods. Then the biomedical applications of Mn-based NMs for ROS-mediated cancer therapy are brought into focus. Finally, the challenges and development directions of Mn-based NMs used for ROS-mediated cancer therapy are rationally analyzed, which are necessary for their future clinical translation.

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Biodegradable oxygen-producing manganese-chelated metal organic frameworks for tumor-targeted synergistic chemo/photothermal/ photodynamic therapy

Cited by 45 publications

References 35 publications

Surprisingly fast assembly of the MOF film for synergetic antibacterial phototherapeutics

Surprisingly fast assembly of the MOF film for synergetic antibacterial phototherapeutics

Bibliometric Analysis of Global Research on Cancer Photodynamic Therapy: Focus on Nano-Related Research

An Overview of Recent Advancements on Manganese-Based Nanostructures and Their Application for ROS-Mediated Tumor Therapy

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