Biodegradable nanoparticles modified by branched polyethylenimine for plasmid DNA delivery

Son, Sejin; Kim, Won Jong

doi:10.1016/j.biomaterials.2009.09.024

Cited by 94 publications

(74 citation statements)

References 30 publications

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“…PLGAs having different compositions of LA and GA have been commercially developed and are being investigated for a broad spectrum of biomedical applications. PLGA-based nanoparticles (NPs) have garnered tremendous attention as nonviral polymeric vectors in investigating delivery of nucleic acid owing to their small particle size, favorable safety profile, and sustained-release characteristics (Son and Kim, 2010). siRNA-loaded PLGA NPs have shown great promise in in vitro gene silencing (Yuan et al, 2006).…”

Section: Poly(dl-lactide-co-glycolide)mentioning

confidence: 99%

Polymers in Small-Interfering RNA Delivery

Singha

Namgung

Kim

2011

Nucleic Acid Therapeutics

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181

112

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This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers-containing different nanoparticles. The article will provide a brief and concise account of underlying principle of these polymeric vectors and their structural and functional modifications which were intended to serve different purposes to affect efficient therapeutic outcome of small-interfering RNA delivery. The modifications of these polymeric vectors will be discussed with reference to stimuli-responsiveness, target specific delivery, and incorporation of nanoconstructs such as carbon nanotubes, gold nanoparticles, and silica nanoparticles. The emergence of small-interfering RNA as the potential therapeutic agent and its mode of action will also be mentioned in a nutshell.

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Section: Poly(dl-lactide-co-glycolide)mentioning

confidence: 99%

Polymers in Small-Interfering RNA Delivery

Singha

Namgung

Kim

2011

Nucleic Acid Therapeutics

Self Cite

181

112

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“…Two important reaction factors that determine the structure difference of our LGA-PEI polymer with other polymers that include PLGA and PEI are the reaction time of PLGA with PEI and the PLGA to PEI ratio. Thus, our LGA-PEI polymer is a new material, which has differences in chemical structure, properties, functions and potential applications from those reported in literature [44,54,[65][66][67][68][69][70][71].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies reported preparing PLGA NPs bearing PEI on their surface by mixing first the PLGA NP with the water-in-oilin-water technique in PVI solution, and then adding PEI into the solution to form a PEI-coated PLGA NPs [44,54,[65][66][67][68][69][70][71]. In these studies, PLGA NPs are the core, and PEI attached to the surface makes the NPs cationic.…”

Section: Discussionmentioning

confidence: 99%

New Polymer of lactic-co-glycolic acid-modified Polyethylenimine for Nucleic Acid Delivery

Lü

Liang

Wang

et al. 2016

Nanomedicine (Lond.)

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Aim:To develop an improved delivery system for nucleic acids. Materials & methods:We designed, synthesized and characterized a new polymer of lactic-co-glycolic acidmodified polyethylenimine (LGA-PEI). Functions of LGA-PEI polymer were determined. Results:The new LGA-PEI polymer spontaneously formed nanoparticles (NPs) with DNA or RNA, and showed higher DNA or RNA loading efficiency, higher or comparable transfection efficacy, and lower cytotoxicity in several cell types including PANC-1, Jurkat and HEK293 cells, when compared with lipofectamine 2000, branched or linear PEI (25 kDa). In nude mouse models, LGA-PEI showed higher delivery efficiency of plasmid DNA or miRNA mimic into pancreatic and ovarian xenograft tumors.LGA-PEI/DNA NPs showed much lower toxicity than control PEI NPs in mouse models. Conclusion:The new LGA-PEI polymer is a safer and more effective system to deliver DNA or RNA than PEI.

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“…[49][50][51] Ideally, this feature not only enhances therapeutic outcomes through facilitating intracellular release of therapeutic genes, but also reduces cytotoxicity associated with the molecular weight of cationic polymers. 52,53 However, these hydrolytically degradable vectors are prone to degrade within the extracellular environment.…”

Section: S-s-pei/rgdmentioning

confidence: 99%

A review of RGD-functionalized nonviral gene delivery vectors for cancer therapy

et al. 2012

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The development of effective treatments that enable many patients suffering from cancer to be successfully cured is highly demanded. Angiogenesis, which is a process for the formation of new capillary blood vessels, has a crucial role in solid tumor progression and the development of metastasis. Antiangiogenic therapy designed to prevent tumor angiogenesis, thereby arresting the growth or spread of tumors, has emerged as a non-invasive and safe option for cancer treatment. Due to the fact that integrin receptors are overexpressed on the surface of angiogenic endothelial cells, various strategies have been made to develop targeted delivery systems for cancer gene therapy utilizing integrin-targeting peptides with an exposed arginine-glycine-aspartate (RGD) sequence. The aim of this review is to summarize the progress and prospect of RGD-functionalized nonviral vectors toward targeted delivery of genetic materials in order to achieve an efficient therapeutic outcome for cancer gene therapy, including antiangiogenic therapy.

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Biodegradable nanoparticles modified by branched polyethylenimine for plasmid DNA delivery

Cited by 94 publications

References 30 publications

Polymers in Small-Interfering RNA Delivery

Polymers in Small-Interfering RNA Delivery

New Polymer of lactic-co-glycolic acid-modified Polyethylenimine for Nucleic Acid Delivery

A review of RGD-functionalized nonviral gene delivery vectors for cancer therapy

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