Biodegradable nanofiber-membrane for sustainable release of lidocaine at the femoral fracture site as a periosteal block: In vitro and in vivo studies in a rabbit model

Chou, Ying‐Chao; Cheng, Yi-Shiun; Hsu, Yung‐Heng; Yu, Yi‐Hsun; Liu, Shih‐Jung

doi:10.1016/j.colsurfb.2016.01.011

Cited by 13 publications

(5 citation statements)

References 28 publications

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“…Some drugs such as insulin [20], paclitaxel [21], azithromycin [22], triamcinolone acetonide [23], methylprednisolone acetate [24], ibuprofen [25], naproxen [26], etc. [27][28][29][30][31][32][33][34] have been prepared by this method.…”

Section: Introductionmentioning

confidence: 99%

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations

Garjani

Barzegar-Jalali

Osouli-Bostanabad

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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The aim of this study was to fabricate propranolol hydrochloride (Prop. HCl) (as a water-soluble drug):Eudragit RS100 (Eud) nanobeads and nanofibres applying the electrospraying method as an economical and one-step technique. Different ratios of Prop. HCl:Eud (i.e. 1:5 and 1:10) at total solution concentrations of 10-20% W/V were investigated. The FE-SEM studies revealed that morphology and size of the samples were highly affected by the solution concentration; so that, the nanobeads (a mean diameter of 82.9 nm) were formed in low concentration and at the highest concentration of the solution, nanofibres (a mean diameter of 232.3 nm) were resulted. Besides the morphological changes, the size of processed nanoformulations was increased with an increment of the solution concentrations. X-ray diffraction results as well as DSC thermograms clearly indicated that the drug crystallinity decreased in the electrosprayed samples. Furthermore, in vitro dissolution test showed that the electrosprayed samples had relatively slower release patterns toward the pure drug and physical mixtures, where the samples with the drug:polymer ratio of 1:10 indicated a faster release rate toward 1:5 ratio; nevertheless, the concentration of the injected formulations did not remarkably impressed the release behaviours. The current study established the suitability of electrospraying method in the fabrication of the water-soluble drugs nanobeads/nanofibres; however, in vivo effectiveness of the prepared nanoformulations should be meticulously considered.

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Section: Introductionmentioning

confidence: 99%

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations

Garjani

Barzegar-Jalali

Osouli-Bostanabad

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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“…The strand, fabricated by electrospraying, exhibited a smooth surface regardless of the presence of the drug (Figure S1). As shown in the FTIR spectra in Figure 3a, lidocaine exhibited the characteristic peaks at 3030 cm −1 , 1630–1690 cm −1 , 1450–1600 cm −1 , and 3400 cm −1 due to the benzene ring, carbonyl group, C=C, and NH bonds, respectively 31‐33 …”

Section: Resultsmentioning

confidence: 99%

Indwelling urinary catheter assembled with lidocaine‐loaded polymeric strand for local sustained alleviation of bladder discomfort

Kim

Jang

Yoon

et al. 2021

Bioengineering & Transla Med

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“…a)). These three peaks are attributed to C-C stretching vibration, C=C bond and benzene ring of lidocaine hydrochloride [20], respectively. Their presence in FTIR spectra of all PMNC/ MN-L samples (Fig.…”

Section: Characterization Of Pmnc/mn-l Samplesmentioning

confidence: 99%

Dual responsive hybrid hydrogels for controlled release of local anesthetic

Markovič

Šešlija

Panic

et al. 2022

procteh

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Inteligent hydrogels, such as pH sensitive hydrogels based on poly(methacrylic acid) (PMAA) are widely used for targeted drug delivery. Still, PMAA lack of good mechanical properties often limits its application. In order to overcome this limitation nanocellulose (NC) was extracted from wood waste material and then added to PMAA because NC is biocompatible, non-toxic and has excellent mechanical properties. Further, carboxymethyl cellulose (CMC) (cellulose derivate widely used for controlled release of drugs) was added. CMC can stabilize magnetite nanoparticles (MN) which is then also added. MN can significantly improve mechanical properties of hydrogels and also possess magnetic properties due to which MN can be used for targeted drug delivery. The as-prepared material can protect drug, deliver it to the site of action, control its release rate and enable in that way its efficient application with reduced side effects. Local anesthetic - lidocaine hydrochloride (LH) is often administrated by injection which can induce severe side effects. This problem is solved in present study by encapsulating LH into hydrogels based on PMAA, NC, CMC and MN (PMNC/MN-L). PMNC/MN-L hydrogels were characterized by FTIR and SEM spectroscopies and single compressive tests and then their swelling behavior and LH release were analyzed. Present study offers unique approach for green synthesis of dual responsive hydrogels with improves properties and their application for controlled release of local anesthetic with reduced side effects.

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Biodegradable nanofiber-membrane for sustainable release of lidocaine at the femoral fracture site as a periosteal block: In vitro and in vivo studies in a rabbit model

Cited by 13 publications

References 28 publications

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations

Indwelling urinary catheter assembled with lidocaine‐loaded polymeric strand for local sustained alleviation of bladder discomfort

Dual responsive hybrid hydrogels for controlled release of local anesthetic

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Biodegradable nanofiber-membrane for sustainable release of lidocaine at the femoral fracture site as a periosteal block: In vitro and in vivo studies in a rabbit model

Cited by 13 publications

References 28 publications

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit® RS100 electrosprayed nanoformulations

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit® RS100 electrosprayed nanoformulations

Indwelling urinary catheter assembled with lidocaine‐loaded polymeric strand for local sustained alleviation of bladder discomfort

Dual responsive hybrid hydrogels for controlled release of local anesthetic

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Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations