Biodegradable nanofiber bone-tissue scaffold as remotely-controlled and self-powering electrical stimulator

Das, Ritopa; Curry, Eli; Le, Thinh T.; Awale, Guleid; Liu, Yang; Li, Shunyi; Contreras, Joemart; Bednarz, Casey; Millender, Jayla; Xin, Xiaonan; Rowe, David W.; Emadi, Sharareh; Lo, Kevin W.‐H.; Nguyen, Thanh D.

doi:10.1016/j.nanoen.2020.105028

Cited by 82 publications

(74 citation statements)

References 52 publications

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“…Applications human-machine interface [20,55] motion monitoring [19,29,37,50] anti-bacteria [99] in vivo health monitoring [83,97,119] motion monitoring [21,27,33,56,74] health monitoring [18,49,52] anti-tumor therapy [94] in vivo therapying [29,103,104,114] health monitoring [27,45,78] wound healing [79] in vivo health monitoring [101,105,120] regeneration of tissues [85] eye motion monitoring [23,28] power supply [18,32,72,77] electrical stimulator [98] implanted sensor [112] voice and gesture recognition [20,44,65] power supply [87,88,92,93] power supply [84,106,…”

Section: Location Of Installationmentioning

confidence: 99%

“…The PENG is fixed on the lead of the pacemaker to harvest energy from the lead's motion caused by heartbeats. Zhiran Yi et al proposed a self-powered leadless cardiac pacemaker [96] [85], as shown in Figure 9e. A biodegradable PENG scaffold driven by ultrasound is adapted as an electrical stimulator to promote bone regeneration.…”

Section: Self-powered Implantable Systems Based On Pengmentioning

confidence: 99%

“…It plays a role as an in vivo stimulus to accelerate the speed of tissue healing and nerve conducting. Ritopa Das et al proposed a new method for bone regeneration [85], as shown in Figure 9e. A biodegradable PENG scaffold driven by ultrasound is adapted as an electrical stimulator to promote bone regeneration.…”

Section: Self-powered Implantable Systems Based On Pengmentioning

confidence: 99%

“…The TENGs and PENGs are integrated into wearable textiles and shoes [32,48] or mounted on human skin [55,60], serving as power supplies or active sensor for motion and vital signs monitoring [32,48,55,60]. In addition, the implanted nanogenerators, which are biocompatible and even biodegradable [85], play an influential role in biomedical applications to power implanted devices [99,101], to record biological signals, and to stimulate muscles and the nervous system in therapy use [85,98]. which is a milestone discovery in energy harvesting and self-powered systems.…”

Section: Introductionmentioning

confidence: 99%

“…(f) A biodegradable, battery-less electrical stimulator made of piezoelectric nanofibers, serves as a bone scaffold. Reproduced with permission from Ref [85]…”

mentioning

confidence: 99%

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Progress on Self-Powered Wearable and Implantable Systems Driven by Nanogenerators

Yang

Tian

et al. 2021

Micromachines

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With the rapid development of the internet of things (IoT), sustainable self-powered wireless sensory systems and diverse wearable and implantable electronic devices have surged recently. Under such an opportunity, nanogenerators, which can convert continuous mechanical energy into usable electricity, have been regarded as one of the critical technologies for self-powered systems, based on the high sensitivity, flexibility, and biocompatibility of piezoelectric nanogenerators (PENGs) and triboelectric nanogenerators (TENGs). In this review, we have thoroughly analyzed the materials and structures of wearable and implantable PENGs and TENGs, aiming to make clear how to tailor a self-power system into specific applications. The advantages in TENG and PENG are taken to effectuate wearable and implantable human-oriented applications, such as self-charging power packages, physiological and kinematic monitoring, in vivo and in vitro healing, and electrical stimulation. This review comprehensively elucidates the recent advances and future outlook regarding the human body’s self-powered systems.

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Section: Location Of Installationmentioning

confidence: 99%

Section: Self-powered Implantable Systems Based On Pengmentioning

confidence: 99%

Section: Self-powered Implantable Systems Based On Pengmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…(f) A biodegradable, battery-less electrical stimulator made of piezoelectric nanofibers, serves as a bone scaffold. Reproduced with permission from Ref [85]…”

mentioning

confidence: 99%

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Progress on Self-Powered Wearable and Implantable Systems Driven by Nanogenerators

Yang

Tian

et al. 2021

Micromachines

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Advances in Triboelectric Nanogenerators for Self‐Powered Regenerative Medicine

Parandeh

Etemadi

Kharaziha

et al. 2021

Adv Funct Materials

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Over the last decade, in pursuit to provide suitable alternatives for power supplies of medical devices in regenerative medicine, extensive research on nanogenerators has been developed. Such devices can overcome current commercial battery challenges, including intense heat-on-body complications due to the electrical current during therapeutic usage, leading to protein denaturation, cell structure destruction, and even cell necrosis. In addition, these traditional batteries contain a bulky and heavy structure that prevents them from providing sustainable on body biomedical therapeutic intervention. Furthermore, advantages such as wide-range biocompatible and biodegradable materials, lightweight, and sufficient stretchability for device construction can minimize the side effects of implantable devices, including inflammation or toxicity, as well as eliminate secondary surgery to replace or remove batteries. Triboelectric nanogenerators (TENGs) are associated with harvesting mechanical energy in various forms, among which human body motions can serve as a renewable power source for healthcare systems. This review is written to emphasize the importance of TENG's applications in regenerative medicine and modulation purposes, particularly for the nervous system. Some crucial parameters for implantable consideration are discussed. In the concluding remarks, features for clinical utilization including output efficiency, encapsulation, stability, and miniaturization are suggested as challenges and prospects.

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Piezoelectric Nanofiber Membrane for Reusable, Stable, and Highly Functional Face Mask Filter with Long‐Term Biodegradability

Curry

Vinikoor

et al. 2022

Adv Funct Materials

Self Cite

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The emergence of the SARS‐CoV‐2 pandemic and airborne particulate matter (PM) pollution has led to remarkably high demand for face masks. However, conventional respirators are intended for single use and made from nondegradable materials, causing serious concern for a plastic‐waste environmental crisis. Furthermore, these facemasks are weakened in humid conditions and difficult to decontaminate. Herein, a reusable, self‐sustaining, highly effective, and humidity‐resistant air filtration membrane with excellent particle‐removal efficiency is reported, based on highly controllable and stable piezoelectric electrospun poly (l‐lactic acid) (PLLA) nanofibers. The PLLA filter possesses a high filtration efficiency (>99% for PM 2.5 and >91% for PM 1.0) while providing a favorable pressure drop (≈91 Pa at normal breathing rate) for human breathing due to the piezoelectric charge naturally activated by respiration through the mask. The filter has a long, stable filtration performance and good humidity resistance, demonstrated by a minimal declination in the filtration performance of the nanofiber membrane after moisture exposure. The PLLA filter is reusable via common sterilization tools (i.e., an ultrasonic cleaning bath, autoclave, or microwave). Moreover, a prototype of a completely biodegradable PLLA nanofiber‐based facemask is fabricated and shown to decompose within 5 weeks in an accelerated degradation environment.

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Biodegradable nanofiber bone-tissue scaffold as remotely-controlled and self-powering electrical stimulator

Cited by 82 publications

References 52 publications

Progress on Self-Powered Wearable and Implantable Systems Driven by Nanogenerators

Progress on Self-Powered Wearable and Implantable Systems Driven by Nanogenerators

Advances in Triboelectric Nanogenerators for Self‐Powered Regenerative Medicine

Piezoelectric Nanofiber Membrane for Reusable, Stable, and Highly Functional Face Mask Filter with Long‐Term Biodegradability

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