Biodegradable Nanodots: Biodegradable Self‐Assembled Ultrasmall Nanodots as Reactive Oxygen/Nitrogen Species Scavengers for Theranostic Application in Acute Kidney Injury (Small 8/2021)

Zhang, Dongyang; Liu, Hengke; He, Ting; Younis, Muhammad Rizwan; Tu, Tianhui; Yang, Chen; Zhang, Jing; Lin, Jing; Qu, Junle; Huang, Peng

doi:10.1002/smll.202170033

Cited by 1 publication

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“…Because of their excellent enrichment in the kidney and unique multienzyme simulation ability, ultrasmall PB nanoenzyme have shown better therapeutic effects than amifostine in rhabdomyolysis- or cisplatin-induced AKI mouse models ( Zhang et al, 2021c ). As a broad-spectrum ROS scavenger, self-assembled ultrasmall nanoparticles (FGP nanoparticles) composed of iron ions, gallic acid and polyvinylpyrrolidone can alleviate mouse AKI induced by glycerol and cisplatin ( Zhang et al, 2021b ). After the combination of Mn 2+ -chelated melanin (MMP) nanoparticles and polyethylene glycol, the obtained coordination assembled MMPP nanoparticles have the ability to eliminate a variety of reactive oxygen free radicals and inhibit the oxidative stress induced by reactive oxygen species ( Sun et al, 2019 ).…”

Section: The Application Of Nanosystems For Oxidative Stress Regulati...mentioning

confidence: 99%

Nanosystems for oxidative stress regulation in the anti-inflammatory therapy of acute kidney injury

Wang

Jiang

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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Acute kidney injury (AKI) is a clinical syndrome that results from a rapid decline in renal structure or renal functional impairment with the main pathological feature of sublethal and lethal damage to renal tubular cells. However, many potential therapeutic agents cannot achieve the desired therapeutic effect because of their poor pharmacokinetics and short retention time in the kidneys. With the recent emergence and progress of nanotechnology, nanodrugs with unique physicochemical properties could prolong circulation time, enhance efficient targeted delivery, and elevate the accumulation of therapeutics that can cross the glomerular filtration barrier and indicate comprehensive application prospects in the prevention and treatment of AKI. In this review, various types of nanosystems (such as liposomes, polymeric nanosystems, inorganic nanoparticles and cell-derived extracellular vesicles) are designed and applied to improve the pharmacokinetics of drug formation, which could further relieve the burden on the kidneys caused by the final cumulative dose of drugs in conventional treatments. Moreover, the passive or active targeting effect of nanosystems can also reduce the total therapeutic dose and off-target adverse effects on other organs. Nanodelivery systems for treating AKI that alleviate oxidative stress-induced renal cell damage and regulate the inflammatory kidney microenvironment are summarized.

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Section: The Application Of Nanosystems For Oxidative Stress Regulati...mentioning

confidence: 99%

Nanosystems for oxidative stress regulation in the anti-inflammatory therapy of acute kidney injury

Wang

Jiang

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

Biodegradable Nanodots: Biodegradable Self‐Assembled Ultrasmall Nanodots as Reactive Oxygen/Nitrogen Species Scavengers for Theranostic Application in Acute Kidney Injury (Small 8/2021)

Cited by 1 publication

References 0 publications

Nanosystems for oxidative stress regulation in the anti-inflammatory therapy of acute kidney injury

Nanosystems for oxidative stress regulation in the anti-inflammatory therapy of acute kidney injury

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