Biodegradable membrane of poly(l-lactide acid-dioxanone-glycolide) and stereocomplex poly(lactide) with enhanced crystallization and biocompatibility

Abstract

The membranes of poly(l-lactide acid-p-dioxanone-glycolide) (PLPG) with stereocomplex poly(lactic acid) (sc-PLA) were prepared by the solution blending way. It was observed that sc-PLA significantly heightened the crystallizing behavior of PLLA segments of the PLPG matrix. The crystallizing behavior displayed that the temperature of crystallization shifted to a higher range than that of PLPG. Moreover, the half-time of crystallization sharply decreased in value as the sc-PLA content increased in value on account of the pre-eminent nucleation ability of sc-PLA. TGA results revealed the thermal stability of the samples with the increase of sc-PLA compared to PLPG. Meanwhile, enzymatic degradation results indicated that the mass loss rate of the membrane decreased with the introduction of sc-PLA, but the overall degradation ability was still greater than that of PLLA. In the meantime, the biological experiment indicated that the membrane possessed low cytotoxicity.

High improvement of interfacial and mechanical properties in reinforcedPPcomposite by grafting polyethyleneimine modified carboxylicmulti‐walledcarbon nanotubes on short carbon fiber

“…For fiber reinforced semicrystalline polymer composites, TC structure at the interface is a significant physical interaction 42,43 . The raw CF is lack of nucleation points and difficult to induce TC formation.…”

“…For fiber reinforced semicrystalline polymer composites, TC structure at the interface is a significant physical interaction. 42,43 The raw CF is lack of nucleation points and difficult to induce TC formation. The PEI-CNT coating layer brought plenty of nucleation sites to strengthen the crystalline ability of CF.…”

Human umbilical cord blood mononuclear cells laden hydrogels made from carboxymethyl chitosan and oxidized hyaluronic acid for wound healing

“…It has been reported that 3D ECM gels can promote the growth of stem cells 24 . HA based hydrogels attracted much interest for applications in drug delivery, wound healing and tissue engineering due to their outstanding biocompatibility and biodegradability 25–27 . The oxidation of HA generates aldehyde‐containing HA (A‐HA) whose aldehyde groups can react with amino groups to form hydrogels by Schiff base reaction 28 .…”

Poly(trimethylene carbonate)‐b‐poly(ethylene glycol) diblock copolymer micelles for hydrophobic drug delivery: The effect of hydrophilic/hydrophobic segment length on micellar properties and drug loading

“…4,5 Among these systems, there has been considerable interest in the use of polymeric micelles delivery systems composed of biocompatible, biodegradable amphiphilic diblock copolymers. [6][7][8][9] These copolymers are composed of a hydrophobic block, such as poly(lactic acid), poly(lactic-coglycolic acid) and poly(caprolactone), and a hydrophilic block which is typically poly(ethylene glycol) (PEG). [10][11][12] These amphiphilic block copolymers are able to self-assemble in aqueous media to form micelles with a core-shell structure, which are composed of a hydrophobic core surrounded by a highly water bond hydrophilic PEG corona.…”

“…A search for improving the solubility of hydrophobic drugs has led to the application of many drug delivery systems such as parenteral emulsion, liposomes, nanoparticles, polymeric micelles, and conjugates 4,5 . Among these systems, there has been considerable interest in the use of polymeric micelles delivery systems composed of biocompatible, biodegradable amphiphilic diblock copolymers 6–9 . These copolymers are composed of a hydrophobic block, such as poly(lactic acid), poly(lactic‐co‐glycolic acid) and poly(caprolactone), and a hydrophilic block which is typically poly(ethylene glycol) (PEG) 10–12 .…”