Biodegradable Materials for Tissue Engineering: Development, Classification and Current Applications

Modrák, Marcel; Trebuňová, Marianna; Balogová, Alena Findrik; Hudák, Radovan; Živčák, Jozef

doi:10.3390/jfb14030159

Cited by 17 publications

(6 citation statements)

References 141 publications

(143 reference statements)

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“…Titanium biomaterials are still widely used for the manufacture of implants. Provided they are properly processed, they enable reliable long-term implant performance even in stressful situations [1,9]. Wang et al in his work pointed out scaffolds made of titanium and its alloys as suitable for the production of implants and the repair of bone defects, used primarily in orthopedics, due to their advanced mechanical properties, corrosion resistance and favorable osseointegration [2].…”

Section: Discussionmentioning

confidence: 99%

Surface Biocompatibility of Porous Titanium Structures With Stem Cells

Trebuňová,

Demeterová,

Bačenková

et al. 2023

Clin Tech

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Successful tissue regeneration requires scaffolds with mechanical stability or biodegradability, surface roughness, and porosity to provide a suitable microenvironment for sufficient cell interaction, migration, cell proliferation, and differentiation. This study features the design, fabrication, and biocompatibility testing of Ti-6Al-4V titanium alloy scaffolds. Cylindrical titanium samples were tested, where each sample had a porous structure with pore sizes of 0.4 mm, 0.8 mm, and 1.0 mm respectively, which were seeded with chorionic-derived mesenchymal stem cells (CMSCs). The viability of the seeded CMSCs was evaluated using the MTT test. The aim of the study was to evaluate the cytotoxic effect and biocompatibility of porous titanium scaffolds. CMSCs showed the highest viability, adhesion to surfaces, and good proliferation on samples with 0.4 mm pore size, on the other hand, the pore size of 1.0 mm showed relatively lowest compatibility with cells and their proliferation. However, the viability of cells on all tested sizes of porous titanium scaffolds showed sufficient viability for future use in regenerative medicine.

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Section: Discussionmentioning

confidence: 99%

Surface Biocompatibility of Porous Titanium Structures With Stem Cells

Trebuňová,

Demeterová,

Bačenková

et al. 2023

Clin Tech

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“…The process of degradation and he longevity of a scaffold material in the biological system are key factors in selecting the biomaterial therapeutics [33]. The process of degradation can be hydrolysis and or enzymatic, and the resulting degraded products should be non-immunogenic and non-toxic and are incorporated into metabolic pathways or excreted [34].…”

Section: Biodegradabilitymentioning

confidence: 99%

Chitosan-2D Nanomaterial-Based Scaffolds for Biomedical Applications

Naskar,

Kilari,

Misra

2024

Polymers

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Chitosan (CS) and two-dimensional nanomaterial (2D nanomaterials)-based scaffolds have received widespread attention in recent times in biomedical applications due to their excellent synergistic potential. CS has garnered much attention as a biomedical scaffold material either alone or in combination with some other material due to its favorable physiochemical properties. The emerging 2D nanomaterials, such as black phosphorus (BP), molybdenum disulfide (MoS2), etc., have taken huge steps towards varying biomedical applications. However, the implementation of a CS-2D nanomaterial-based scaffold for clinical applications remains challenging for different reasons such as toxicity, stability, etc. Here, we reviewed different types of CS scaffold materials and discussed their advantages in biomedical applications. In addition, a different CS nanostructure, instead of a scaffold, has been described. After that, the importance of 2D nanomaterials has been elaborated on in terms of physiochemical properties. In the next section, the biomedical applications of CS with different 2D nanomaterial scaffolds have been highlighted. Finally, we highlighted the existing challenges and future perspectives of using CS-2D nanomaterial scaffolds for biomedical applications. We hope that this review will encourage a more synergistic biomedical application of the CS-2D nanomaterial scaffolds and their utilization clinical applications.

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“…Accordingly, it is important to choose materials with the ability to suppress excessive inflammation [ 165 ]. Furthermore, efforts have been made to design biodegradable polymers that selectively activate the M2 phenotype of macrophages [ 166 ]. In order to drive primary human macrophage elongation and differentiation towards the anti-inflammatory, pro-healing M2 type, a previous study showed that the control of biomaterial geometry using melt electrowriting to create fibrous scaffolds with box-shaped pores and inter-fiber spacing can potentially enhance tissue regeneration [ 167 ].…”

Section: Mechanisms Of Host-biomaterials Interactionmentioning

confidence: 99%

Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview

Hassan,

Krieg,

Kopp

et al. 2024

IJMS

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Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening and vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial for the development of these implants. To achieve implant success, an understanding of the cellular responses post-implantation, proper model selection, and good study design are crucial. There are several challenges to reaching a safe and effective translation of laboratory findings into clinical practice. The utilization of Mg-based biomedical devices eliminates the need for biomaterial removal surgery post-healing and mitigates adverse effects associated with permanent biomaterial implantation. However, the high corrosion rate of Mg-based implants poses challenges such as unexpected degradation, structural failure, hydrogen evolution, alkalization, and cytotoxicity. The biocompatibility and degradability of materials based on magnesium have been studied by many researchers in vitro; however, evaluations addressing the impact of the material in vivo still need to be improved. Several animal models, including rats, rabbits, dogs, and pigs, have been explored to assess the potential of magnesium-based materials. Moreover, strategies such as alloying and coating have been identified to enhance the degradation rate of magnesium-based materials in vivo to transform these challenges into opportunities. This review aims to explore the utilization of Mg implants across various biomedical applications within cellular (in vitro) and animal (in vivo) models.

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Biodegradable Materials for Tissue Engineering: Development, Classification and Current Applications

Cited by 17 publications

References 141 publications

Surface Biocompatibility of Porous Titanium Structures With Stem Cells

Surface Biocompatibility of Porous Titanium Structures With Stem Cells

Chitosan-2D Nanomaterial-Based Scaffolds for Biomedical Applications

Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview

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