Biodegradable magnesium nanoparticle-enhanced laser hyperthermia therapy

Abstract

Background:Recently, nanoparticles have been demonstrated to have tremendous merit in terms of improving the treatment specificity and thermal ablation effect on tumors. However, the potential toxicity and long-term side effects caused by the introduced nanoparticles and by expelling them out of the body following surgery remain a significant challenge. Here, we propose for the first time to directly adopt magnesium nanoparticles as the heating enhancer in laser thermal ablation to avoid these problems by making full use of the perfect biodegradable properties of this specific material. Methods: To better understand the new nano "green" hyperthermia modality, we evaluated the effects of magnesium nanoparticles on the temperature transients inside the human body subject to laser interstitial heating. Further, we experimentally investigated the heating enhancement effects of magnesium nanoparticles on a group of biological samples: oil, egg white, egg yolk, in vitro pig tissues, and the in vivo hind leg of rabbit when subjected to laser irradiation. Results: Both the theoretical simulations and experimental measurements demonstrated that the target tissues injected with magnesium nanoparticles reached much higher temperatures than tissues without magnesium nanoparticles. This revealed the enhancing behavior of the new nanohyperthermia method. Conclusion: Given the unique features of magnesium nanoparticles -their complete biological safety and ability to enhance heating -which most other advanced metal nanoparticles do not possess, the use of magnesium nanoparticles in hyperthermia therapy offers an important "green" nanomedicine modality for treating tumors. This method has the potential to be used in clinics in the near future.

Effects of magnesium oxide nanoparticles on memory impairment induced by postpartum depression model

“…Today magnesium oxide nanoparticles (MgO NPs) are using for medical treatment and drugs transfer (Abdolahzadeh et al, 2014;Mohammed et al, 2017). MgO NPs after entering the body can be more effective than bulk form (Wang et al, 2012;Jahangiri et al, 2013). They have a higher surface to volume ratio compared to conventional composition and increased absorption rate and nanoparticles are affected better and faster than their natural forms (Archakov et al, 2010).…”

Heat Generation in Irradiated Solutions Containing Magnesium Nanoparticle Aggregates

“…Biodegradable magnesium nanoparticles (Mg NPs), were proposed as an alternative safe NIR radiation agent, [11][12][13] for mild hyperthermia treatment. The heating ability of various concentrations of Mg nanosphere solutions based in water and oil were investigated [16]. An apparent increase in temperature has been observed in both numerical and experimental results when Mg NPs were irradiated by NIR laser light.…”

“…Since the heating ability of Mg NPs depends on their optical properties, the heat generation can be impacted by formation of aggregates and self-assemblies [17,18]. Therefore, it is important to understand and predict the optical properties of Mg nanosphere clusters when the solutions are not uniformly dispersed [16]. To analyse this problem in the current paper the optical properties of a single nanosphere and of Mg NP clusters were calculated via the use of discrete dipole approximation (DDA).…”

“…To analyse this problem in the current paper the optical properties of a single nanosphere and of Mg NP clusters were calculated via the use of discrete dipole approximation (DDA). To investigate the impact of the optical properties on heat generation efficiency of irradiated Mg NP aqueous solutions, a computational model was developed and validated using experimental data [16].…”

“…To demonstrate the impact of the optical properties on heat generation efficiency of irradiated aqueous solutions with different Mg NPs structures a computational model for both radiative and transient heat transfer was developed. This model is based on the experimental set up of Wang, et al [16], where an 808 nm, 1.5 W laser was adopted above the top surface of 10 ml samples of oil, with different concentrations of 80 nm diameter magnesium nanoparticles as shown in Fig. 1.…”