Biodegradable magnesium–hydroxyapatite metal matrix composites

Witte, Frank; Feyerabend, Frank; Maier, Petra; Fischer, J.; Störmer, M.; Blawert, Carsten; Dietzel, W.; Hort, Norbert

doi:10.1016/j.biomaterials.2006.12.027

Cited by 596 publications

(348 citation statements)

References 28 publications

(14 reference statements)

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“…The results showed that the hemolysis rate of calcium phosphate coated NZK alloy was 4.8%, lower than 5%, implying that the calcium phosphate coated NZK alloy will not cause severe damage to erythrocytes. A previous study [16] has demonstrated that untreated pure magnesium and other magnesium alloys (e.g. Mg-Zn-Mn alloy) had obvious hemolytic effects on human erythrocytes.…”

Section: Biocompatibility Of Nzk Alloymentioning

confidence: 99%

“…Mg-Zn-Mn alloy) had obvious hemolytic effects on human erythrocytes. It is believed that the magnesium and its alloys degraded too fast and the high concentration of magnesium in the solution was responsible for the high hemolysis rate [16]. The calcium phosphate coated NZK alloy had no obvious hemolysis, probably because neodymium, zinc and zirconium can improve corrosion resistance and thus slow the release rate of magnesium ions into blood fluid.…”

Section: Biocompatibility Of Nzk Alloymentioning

confidence: 99%

“…In recent years, along with development in metallurgy, magnesium alloys have gained renewed interest as appropriate degradable biomaterials. Up until now, many different kinds of magnesium alloy materials, such as bulk materials [8][9][10][11], scaffolds [14,15], and composites [16][17][18], have been investi-gated as potential implant materials. Unfortunately, fast degradation of magnesium alloys via corrosion in the human environment may limit their clinical applications [1,2].…”

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confidence: 99%

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In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy

Wang

Zhu

et al. 2012

Chin. Sci. Bull.

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In this study, in vitro degradation and biocompatibility of Mg-Nd-Zn-Zr (NZK) alloy were investigated to determine its suitability as a degradable medical biomaterial. Its corrosion properties were evaluated by static immersion test, electrochemical corrosion test, scanning electron microscopy (SEM), and energy dispersive spectroscopic (EDS) analysis, and in vitro biocompatibilities were assessed by hemolysis and cytotoxicity tests. Pure magnesium was used as control. The results of static immersion test and electrochemical corrosion test in simulated body fluid (SBF) demonstrated that the addition of alloying elements could improve the corrosion resistance. The hemolysis test found that the hemolysis rate of calcium phosphate coated NZK alloy was 4.8%, which was lower than the safe value of 5%. The cytotoxicity test indicated that NZK alloy extracts did not significantly reduce MC 3 T 3 -E 1 cell viability. Hemolysis test and cytotoxicity test display excellent hemocompatibility and cytocompatibility of NZK alloy in vitro. Our data indicate that NZK alloy has excellent biocompatibility and thus can be considered as a potential degradable medical biomaterial for orthopedic applications.

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Section: Biocompatibility Of Nzk Alloymentioning

confidence: 99%

Section: Biocompatibility Of Nzk Alloymentioning

confidence: 99%

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confidence: 99%

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In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy

Wang

Zhu

et al. 2012

Chin. Sci. Bull.

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“…Enhanced mechanical properties have been reported in Mg composites reinforced with nanoscaled ceramic particles such as hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ) (Ref 15,16). HA is chemically similar to the mineral component of bones and hard tissues in mammals.…”

Section: Introductionmentioning

confidence: 99%

“…Coatings of hydroxyapatite are often applied to metallic implants (titanium, titanium alloys and stainless steels) to modify the surface properties, but in many cases satisfactory results are not achieved, due to crack formation or badly controlled adjustment of the specific apatite phases. Latest studies have focused on the possibility of its application in composite form, in materials combining metal with bioceramic ( Ref 3,[15][16][17][18][19]. These studies aim at optimizing the mechanical properties of the composites.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Hydroxyapatite Addition on the Properties of the Mechanically Alloyed and Sintered Mg-RE-Zr Alloy

Kowalski

Nowak

Jakubowicz

et al. 2016

J. of Materi Eng and Perform

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This paper discusses the influence of the chemical composition on the microstructure, mechanical and corrosion properties of mechanically alloyed and sintered (Mg-4Y-5.5Dy-0.5Zr)-x wt.% HA composites. Mechanical alloying for 25 h of the Mg-4Y-5.5Dy-0.5Zr composition, followed by sintering under argon at 550°C for 2 h, led to the formation of a bulk alloy with an ultrafine grained microstructure. With the increase of the hydroxyapatite content in the (Mg-4Y-5.5Dy-0.5Zr)-x wt.% HA composite, a reduction of the grain sizes of the bulk material was noticeable. In the case of the bulk (Mg-4Y-5.5Dy-0.5Zr)-10 wt.% HA composite, the grain sizes of approx. 60 nm have been recorded by atomic force microscopy. The final microstructure of the synthesized composites strongly influenced the mechanical and corrosion properties. The Mg-4Y-5.5Dy-0.5Zr alloy was characterized by higher average values of YoungÕs modulus (36.6 GPa). In the case of the (Mg-4Y-5.5Dy-0.5Zr)-5 wt.% HA scaffolds with the porosity of 48%, the YoungÕs modulus was equal to 7.1 GPa. The (Mg-4Y-5.5Dy-0.5Zr)-10 wt.% HA composite was more corrosion resistant (I c = 5.849 3 10 25 A cm 22 , E c = 21.565 V versus SCE) than Mg-4Y-5.5Dy-0.5Zr alloy (I c = 4.838 3 10 24 A cm 22 , E c = 21.555 V versus SCE). The influence of hydrofluoric acid treatment on the corrosion behavior of the (Mg-4Y-5.5Dy-0.5Zr)-5 wt.% HA composite was also investigated. The electrochemical test showed that the corrosion resistance of fluoride-treated specimens was higher, compared with the untreated samples in the RingerÕs solution. In conclusion, fluoride-treated (Mg-4Y-5.5Dy-0.5Zr)-HA composites are biodegradable materials with adjustable mechanical and corrosive properties.

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