“…A prominent example was shown by Yin et al (2023) , who successfully created a biodegradable hydrogel by incorporating silibinin within a blend of pectin and OCMC. Silibinin, an agent with anti-lung cancer properties, selectively targets the TMEM16A ion channel.…”
Section: Pectin Hydrogel Applications In Drug Deliverymentioning
confidence: 99%
“…8 f, the group treated with hydrogel combined with silibinin (100 mg/kg) exhibited a notable tumor weight reduction, compared to the silibinin group (100 mg/kg), while the hydrogel combined with 200 mg/kg silibinin group displayed an even greater reduction in tumor weight. This hydrogel was rapidly formed and exhibited pH-sensitive sustained drug release owing to its acylhydrazone bond crosslinked networks, rendering it suitable for injectable use ( Yin et al, 2023 ). Fig.…”
Section: Pectin Hydrogel Applications In Drug Deliverymentioning
confidence: 99%
“… Fig. 8 In vivo experiment for evaluating the antitumor effect of silibinin incorporated in a hydrogel matrix; (a) graphical representation of the experimental setup; (b) evaluation of tumor size; (c) body weight characterization; (d) mice survival rate; (e) dissected tumor images; (f) tumor weight with respect to different formulations (reproduced with permission from Yin et al, 2023 ). …”
Section: Pectin Hydrogel Applications In Drug Deliverymentioning
confidence: 99%
“… The findings indicated that the silibinin-loaded hydrogel substantially improved in vivo anti-tumor efficacy while markedly decreasing silibinin associated toxicity. ( Yin et al, 2023 ) Poly (3- methoxydiphenylamine)/pristine pectin Ibuprofen When pristine pectin hydrogels are crosslinked with Fe under a 1-V electric potential, the scaling exponent (n) decreases from 1.36 to 0.45 as the Fe crosslinking mole ratio increases. This transition suggests a shift from matrix erosion to a purely Fickian diffusion mechanism.…”
Section: Pectin Hydrogel Applications In Drug Deliverymentioning
“…A prominent example was shown by Yin et al (2023) , who successfully created a biodegradable hydrogel by incorporating silibinin within a blend of pectin and OCMC. Silibinin, an agent with anti-lung cancer properties, selectively targets the TMEM16A ion channel.…”
Section: Pectin Hydrogel Applications In Drug Deliverymentioning
confidence: 99%
“…8 f, the group treated with hydrogel combined with silibinin (100 mg/kg) exhibited a notable tumor weight reduction, compared to the silibinin group (100 mg/kg), while the hydrogel combined with 200 mg/kg silibinin group displayed an even greater reduction in tumor weight. This hydrogel was rapidly formed and exhibited pH-sensitive sustained drug release owing to its acylhydrazone bond crosslinked networks, rendering it suitable for injectable use ( Yin et al, 2023 ). Fig.…”
Section: Pectin Hydrogel Applications In Drug Deliverymentioning
confidence: 99%
“… Fig. 8 In vivo experiment for evaluating the antitumor effect of silibinin incorporated in a hydrogel matrix; (a) graphical representation of the experimental setup; (b) evaluation of tumor size; (c) body weight characterization; (d) mice survival rate; (e) dissected tumor images; (f) tumor weight with respect to different formulations (reproduced with permission from Yin et al, 2023 ). …”
Section: Pectin Hydrogel Applications In Drug Deliverymentioning
confidence: 99%
“… The findings indicated that the silibinin-loaded hydrogel substantially improved in vivo anti-tumor efficacy while markedly decreasing silibinin associated toxicity. ( Yin et al, 2023 ) Poly (3- methoxydiphenylamine)/pristine pectin Ibuprofen When pristine pectin hydrogels are crosslinked with Fe under a 1-V electric potential, the scaling exponent (n) decreases from 1.36 to 0.45 as the Fe crosslinking mole ratio increases. This transition suggests a shift from matrix erosion to a purely Fickian diffusion mechanism.…”
Section: Pectin Hydrogel Applications In Drug Deliverymentioning
“…This method significantly enhanced the antitumor efficiency in vivo and greatly reduced the toxicity of Silibinin. [ 9 ] Jokerst et al. developed an injectable supramolecular hydrogel that can slow and track the release of doxorubicin (DOX) via photoacoustic tomography.…”
The treatment of tumors in developing countries, especially those with poor medical conditions, remains a significant challenge. Herein, a novel solvent‐exchange strategy to prepare adhesive hydrogels for the concurrent treatment of tumors through synchronous ethanol ablation and local chemotherapy is reported. First, a poly (gallic acid‐lipoic acid) (PGL) ethanol gel is prepared that can undergo solvent exchange with water to form a hydrogel in situ. PGL ethanol gel deposited on the wet tissue can form a hydrogel in situ to effectively repel interfacial water and establish a tight contact between the hydrogel and tissue. Additionally, the functional groups between the hydrogels and tissues can form covalent and non‐covalent bonds, resulting in robust adhesion. Furthermore, this PGL ethanol gel demonstrates exceptional capacity to effectively load antitumor drugs, allowing for controlled and sustained release of the drugs locally and sustainably both in vitro and in vivo. In addition, the PGL ethanol gel can combine ethanol ablation and local chemotherapy to enhance the antitumor efficacy in vitro and in vivo. The PGL ethanol gel‐derived hydrogel shows robust wet bioadhesion, drug loading, sustained release, good biocompatibility and biodegradability, easy preparation and usage, and cost‐effectiveness, which make it a promising bioadhesive for diverse biomedical applications.
The creation of functional hydrogels with robust load‐bearing capacity adaptable to complex tissue regeneration remains challenging. Silk fibroin (SF) is a natural biomaterial with excellent mechanical strength and cell adhesion capacity, possessing tremendous potential to solve the aforementioned dilemma. The excellent biodegradability and biocompatibility and the molecular structure with multiple modifiable moieties provide opportunities for the injectability and multifunctionality of hydrogels. Furthermore, the incorporation of other polymers or active ingredients can improve the basic properties, confer biological activities and pharmacological effects, and provide the prerequisites for hydrogels to fulfill specific requirements. Therefore, SF‐based hydrogels are widely applied in tissue repair and regeneration, especially in bone, skin, nerve, liver, myocardium, and cornea, which have effectively addressed the challenges of scaffolds' lack of cell adhesion sites, excessive degradation, as well as the lack of efficient, long‐lasting antimicrobial properties. This review outlines the properties of SF, discusses the types of materials commonly used in the preparation of hydrogels and their characteristics, and describes the current construction methods of SF hydrogels. Simultaneously, recent advancements in applying SF‐based multifunctional hydrogels within biological tissues are explored, with a focus on their role in tissue repair, highlighting the repair mechanism of SF based on bone and skin.
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