Biodegradable Elastomers with Antioxidant and Retinoid-like Properties

Lith, Robert van; Wang, Xuesong

doi:10.1021/acsbiomaterials.5b00534

Cited by 20 publications

(8 citation statements)

References 56 publications

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“…Antioxidant properties of citric acid-based materials are among their most notable advantages for facilitating repair in vivo. 40 These potent antioxidant characteristics are owed to the structure of citric acid, and we thus sought to determine whether PEDOT incorporation impaired the inherent antioxidant capabilities of POCO. A DPPH assay was performed to evaluate the free radical scavenging capabilities of PEDOT-POCO and POCO, with polytetra uoroethylene (PTFE) serving as a negative control (Fig.…”

Section: Resultsmentioning

confidence: 99%

Cell-free biodegradable electroactive scaffold for urinary bladder regeneration

Ameer,

Keate,

Bury

et al. 2024

Preprint

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Tissue engineering heavily relies on cell-seeded scaffolds to support the complex biological and mechanical requirements of a target organ. However, in addition to safety and efficacy, translation of tissue engineering technology will depend on manufacturability, affordability, and ease of adoption. Therefore, there is a need to develop scalable biomaterial scaffolds with sufficient bioactivity to eliminate the need for exogenous cell seeding. Herein, we describe synthesis, characterization, and implementation of an electroactive biodegradable elastomer for urinary bladder tissue engineering. To create an electrically conductive and mechanically robust scaffold to support bladder tissue regeneration, we developed a phase-compatible functionalization method wherein the hydrophobic conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT) was polymerized in situ within a similarly hydrophobic citrate-based elastomer poly(octamethylene-citrate-co-octanol) (POCO) film. We demonstrate the efficacy of this film as a scaffold for bladder augmentation in athymic rats, comparing PEDOT-POCO scaffolds to mesenchymal stromal cell-seeded POCO scaffolds. PEDOT-POCO recovered bladder function and anatomical structure comparably to the cell-seeded POCO scaffolds and significantly better than non-cell seeded POCO scaffolds. This manuscript reports: (1) a new phase-compatible functionalization method that confers electroactivity to a biodegradable elastic scaffold, and (2) the successful restoration of the anatomy and function of an organ using a cell-free electroactive scaffold.

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Section: Resultsmentioning

confidence: 99%

Cell-free biodegradable electroactive scaffold for urinary bladder regeneration

Ameer,

Keate,

Bury

et al. 2024

Preprint

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“…The flexible and stretchable POCO substrate (thickness of 120 µm) provides an elastic support for the BCEP, with an abundance of surface carboxyl groups (‐COOH) that can react with amine groups in the bioadhesive hydrogel. [ 27 ]…”

Section: Resultsmentioning

confidence: 99%

Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology

et al. 2023

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Myocardial infarction (MI) is one of the leading causes of death and disability. Recently developed cardiac patches provide mechanical support and additional conductive paths to promote electrical signal propagation in the MI area to synchronize cardiac excitation and contraction. Cardiac patches based on conductive polymers offer attractive features; however, the modest levels of elasticity and high impedance interfaces limit their mechanical and electrical performance. These structures also operate as permanent implants, even in cases where their utility is limited to the healing period of tissue damaged by the MI. The work presented here introduces a highly conductive cardiac patch that combines bioresorbable metals and polymers together in a hybrid material structure configured in a thin serpentine geometry that yields elastic mechanical properties. Finite element analysis guides optimized choices of layouts in these systems. Regular and synchronous contraction of human induced pluripotent stem cell‐derived cardiomyocytes on the cardiac patch and ex vivo studies offer insights into the essential properties and the bio‐interface. These results provide additional options in the design of cardiac patches to treat MI and other cardiac disorders.

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“…Previously, silicones have been doped with active antioxidant compounds that are released to an external environment. For example, antibiotic surfaces arise from release of eugenol from silicone elastomers, 13 and trans-retinoic acid undergoes release from silicone rubber directly, 14,15 or after enzyme-induced ester hydrolysis. While there are many other examples, most of which are found in the patent literature, of silicones that carry and deliver antioxidants including vitamins, this work is focussed on compounds in which the antioxidant is grafted to the silicone polymer.…”

Section: Introductionmentioning

confidence: 99%