Biodegradable dendritic Boltorn™ nanoconstructs: A promising avenue for cancer theranostics

Korake, Swati; Shaikh, Aazam; Salve, Rajesh; Gajbhiye, Kavita R.; Gajbhiye, Virendra; Pawar, Atmaram

doi:10.1016/j.ijpharm.2020.120177

Cited by 17 publications

(7 citation statements)

References 68 publications

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“…A strategy to improve the performance of MMRI-CA can be highly successful using derivatives of nontoxic nanosized hyperbranched functionalized polyester polyols with a core (ethoxylated pentaerythritol)–shell structure based on 2,2-dimethylolpropionic acid. These branched polyols are biodegradable, have low toxicity, , and are highly soluble in various polar solvents. Due to the presence of end hydroxyl groups, they can be easily functionalized which provides a variety of properties and increases the applications of these compounds including MMRI-CA design.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Nanostructures of Hyperbranched Polyester Loaded with Gd(III) and Dy(III) Ions

Kutyreva,

Vagapova,

Maksimov

et al. 2024

ACS Appl. Polym. Mater.

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Hyperbranched polymers are successful nanoscale functional platforms for loading metal ions and creating promising nanomaterials for medicine. This work presents the synthesis of metal−polymer nanostructures based on a second generation hyperbranched polyester with eight terminal benzoylthiocarbamate (BTC) groups loaded with Gd(III) or Dy(III) ions. Their structure (Fourier transform infrared spectroscopy) and morphology (transmission electron microscopy), photophysical (ultraviolet−visible and luminescence spectroscopy), thermophysical, magnetic activity, relaxivity, and aggregation properties (nanoparticle tracking analysis) were studied. The formation of the metal−polymer complex is carried out by chelation of lanthanide ions −C�O and −C�S groups of the BTC fragment of polyester. Coordination units with composition Ln(III)-3BTC (Ln = Dy, Gd) were localized on the branched polymer platform. The load is three lanthanide ions per branched polyester polybenzoylthiocarbamate macromolecule. Logarithms of stability constants of complexes and composition of coordination polyhedron have been determined. The dysprosium complex is in a paramagnetic state with antiferromagnetic correlations, and the gadolinium complex is in a paramagnetic state. The relaxivity of the Dy(III) and Gd(III) complexes increased by 2.5 and 3 times, respectively, compared to their nitrates. An important achievement is the identification of rare-earth metal (REM)-controlled morphology and self-organization for Dy(III) and Gd(III) complexes with branched polyester polybenzoylthiocarbamate in solution and on the surface. Spherical nanostructures for the dysprosium complex and nanorods for the gadolinium complex were observed. Synthesized REM-loaded nanostructures with polyester polybenzoylthiocarbamates have low hemotoxicity and can be applied in biomedicine.

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Section: Introductionmentioning

confidence: 99%

Hybrid Nanostructures of Hyperbranched Polyester Loaded with Gd(III) and Dy(III) Ions

Kutyreva,

Vagapova,

Maksimov

et al. 2024

ACS Appl. Polym. Mater.

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“…They can be synthesized via the polymerization of multifunctional monomers, so that a wide range of hyperbranched polyester varieties can be obtained: ABn-type hyperbranched polyesters, AB/AB2-type hyperbranched polyesters and polyesteramide hyperbranched polymers [ 8 , 9 , 10 , 11 ]. The AB2-type hyperbranched polyester Boltorn ® (with branches growing on a trialcohol core unit) is even offered as a commercial product, with alcohol groups on surface (standard) or with modified surface groups [ 12 ]. Such a functionalization allows hyperbranched polyesters to find applications in coatings, adhesives, biomedical materials or in nanotechnology.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Morphology Characteristics of New Highly Branched Polycaprolactone PCL

Zioło,

Mossety-Leszczak,

Walczak

et al. 2024

Molecules

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A simple and efficient method for the synthesis of biodegradable, highly branched polycaprolactone (PCL) is presented. The solvent-free (bulk) reaction was carried out via ring opening polymerization (ROP), catalyzed by tin octanoate Sn(Oct)2, and it employed hyperbranched polyamide (HPPA) as a macro-initiator. The core–shell structure of the obtained products (PCL-HPPA), with the hyperbranched HPPA core and linear PCL chains as shell, was in the focus of the product characterization. 1H nuclear magnetic resonance (1H NMR) and elemental analysis confirmed the covalent incorporation of the HPPA in the products, as well as a high degree of grafting conversion of its amino functional groups. Confocal Raman Micro spectroscopy, and especially Time-of-Flight Secondary Ion Mass Spectrometry, further supported the existence of a core–shell structure in the products. Direct observation of macromolecules by means of cryogenic transmission electron microscopy, as well as gel permeation chromatography (GPC), suggested the existence of a minor ‘aggregated’ product fraction with multiple HPPA cores, which was attributed to transesterification reactions. Differential scanning calorimetry, as well as X-ray diffraction, demonstrated that the PCL-HPPA polymers displayed a similar degree of crystallinity to linear neat PCL, but that the branched products possessed smaller and less regular crystallites.

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“…Their peculiar “spongy” architecture allows controlled [ 87 ], targeted [ 88 ], and stimuli-responsive [ 89 ] drug delivery [ 90 , 91 , 92 ]. Further examples deriving from nanomedicine [ 93 , 94 ] include cancer diagnosis [ 95 , 96 ] and therapy [ 97 , 98 ], gene transfection [ 99 , 100 , 101 ], biosensors [ 102 , 103 ], magnetic resonance and bioimaging [ 104 , 105 ] and theranostics [ 106 , 107 ]. Important research is also performed in other clinical fields, such as the treatment of central nervous system conditions [ 108 , 109 ], therapy for inflammatory diseases, such as rheumatoid arthritis [ 110 , 111 ], antimicrobial coatings for orthopedical implants [ 112 , 113 ], and antigen mimicry for vaccinations [ 114 ].…”

Section: Introductionmentioning

confidence: 99%

Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution

et al. 2023

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The capability of radially polymerized bio-dendrimers and hyperbranched polymers for medical applications is well established. Perhaps the most important implementations are those that involve interactions with the regenerative mechanisms of cells. In general, they are non-toxic or exhibit very low toxicity. Thus, they allow unhindered and, in many cases, faster cell proliferation, a property that renders them ideal materials for tissue engineering scaffolds. Their resemblance to proteins permits the synthesis of derivatives that mimic collagen and elastin or are capable of biomimetic hydroxy apatite production. Due to their distinctive architecture (core, internal branches, terminal groups), dendritic polymers may play many roles. The internal cavities may host cell differentiation genes and antimicrobial protection drugs. Suitable terminal groups may modify the surface chemistry of cells and modulate the external membrane charge promoting cell adhesion and tissue assembly. They may also induce polymer cross-linking for healing implementation in the eyes, skin, and internal organ wounds. The review highlights all the different categories of hard and soft tissues that may be remediated with their contribution. The reader will also be exposed to the incorporation of methods for establishment of biomaterials, functionalization strategies, and the synthetic paths for organizing assemblies from biocompatible building blocks and natural metabolites.

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Biodegradable dendritic Boltorn™ nanoconstructs: A promising avenue for cancer theranostics

Cited by 17 publications

References 68 publications

Hybrid Nanostructures of Hyperbranched Polyester Loaded with Gd(III) and Dy(III) Ions

Hybrid Nanostructures of Hyperbranched Polyester Loaded with Gd(III) and Dy(III) Ions

Synthesis and Morphology Characteristics of New Highly Branched Polycaprolactone PCL

Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution

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