Biodegradable core-shell nanoassemblies for the delivery of docetaxel and Zn(II)-phthalocyanine inspired by combination therapy for cancer

Conte, Claudia; Ungaro, Francesca; Maglio, Giovanni; Tirino, Pasquale; Siracusano, Gabriel; Sciortino, Maria Teresa; Leone, Nancy; Palma, Giuseppe; Barbieri, Antônio; Arra, Claudio; Mazzaglia, Antonino; Quaglia, Fabiana

doi:10.1016/j.jconrel.2012.12.026

Cited by 104 publications

(60 citation statements)

References 40 publications

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“…21 Conte et al developed a dual carrier system for co-delivery of DOX and photosensitizer ZnPc based on a biodegradable amphiphilic block copolymer, PEG-b-PCL. 22 The ZnPc/DOX-loaded nanoparticles suppressed the growth of tumor cells more efficiently than nanoparticles loaded only with DOX, thus indicating a combined effect of DOX and ZnPc. Although these non-covalent drug-loaded polymeric micelles are easy to fabricate, micelle structural integrity and drug encapsulation stability are of concern.…”

Section: Introductionmentioning

confidence: 94%

Platinum covalent shell cross-linked micelles designed to deliver doxorubicin for synergistic combination cancer therapy

Zhu¹,

Xiao²,

Tang³

et al. 2017

IJN

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The preparation of polymer therapeutics capable of controlled release of multiple chemotherapeutic drugs has remained a tough problem in synergistic combination cancer therapy. Herein, a novel dual-drug co-delivery system carrying doxorubicin (DOX) and platinum(IV) (Pt[IV]) was developed. An amphiphilic diblock copolymer, PCL-b-P(OEGMA-co-AzPMA), was synthesized and used as a nanoscale drug carrier in which DOX and Pt(IV) could be packaged together. The copolymers were shell cross-linked by Pt(IV) prodrug via a click reaction. Studies on the in vitro drug release and cellular uptake of the dual-drug co-delivery system showed that the micelles were effectively taken up by the cells and simultaneously released drugs in the cells. Futhermore, the co-delivery polymer nanoparticles caused much higher cell death in HeLa and A357 tumor cells than either the free drugs or single-drug-loaded micelles at the same dosage, exhibiting a synergistic combination of DOX and Pt(IV). The results obtained with the shell cross-linked micelles based on an anticancer drug used as a cross-linking linkage suggested a promising application of the micelles for multidrug delivery in combination cancer therapy.

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Section: Introductionmentioning

confidence: 94%

Platinum covalent shell cross-linked micelles designed to deliver doxorubicin for synergistic combination cancer therapy

Zhu¹,

Xiao²,

Tang³

et al. 2017

IJN

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“…6. Nanocarriers combine chemotherapy with physically destructive modalities that induce tumor ablation (photothermal/magnetic) [218][219][220][221][222][223][224][225][226][227][228][229][230][231][232][233][234][235][236]245,246], generate reactive oxygen species (photodynamic) [232][233][234][235][236][237][238][239][240][241][242], and form of free radicals (radiotherapy) to maximize cancer eradication [243]. [246] and demonstrated higher anticancer activity in vitro and in vivo than PTX/PLGA/HAuNPs microspheres alone (no NIR-irradiation) or PLGA/HAuNPs microspheres (no PTX) with NIR irradiation.…”

Section: Combined Photothermal and Chemotherapymentioning

confidence: 99%

“…Anticancer activity of HPNPs against human hepatocellular carcinoma HepG2 cells was significantly increased in vitro and in vivo, according to the irradiation time and number of PDT sessions. DTX-and zinc-phthalocyanine (ZnPc)-loaded "core-shell" NPs that were made of poly(ε-caprolactone) (PCL) and PEG block copolymers [235] showed sustained release of DTX, without ZnPc release, and singlet oxygen generation only upon irradiation at 610 nm. The ZnPc/DTX-loaded NPs exhibited high stability in the presence of serum proteins and a superior anticancer activity in an animal model of orthotopic amelanotic melanoma, as compared to DTX-loaded NPs.…”

Section: Combined Photodynamic and Chemotherapymentioning

confidence: 99%

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

Kemp

Shim

Heo

et al. 2016

Advanced Drug Delivery Reviews

423

258

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a b s t r a c t a r t i c l e i n f oThe dynamic and versatile nature of diseases such as cancer has been a pivotal challenge for developing efficient and safe therapies. Cancer treatments using a single therapeutic agent often result in limited clinical outcomes due to tumor heterogeneity and drug resistance. Combination therapies using multiple therapeutic modalities can synergistically elevate anti-cancer activity while lowering doses of each agent, hence, reducing side effects. Co-administration of multiple therapeutic agents requires a delivery platform that can normalize pharmacokinetics and pharmacodynamics of the agents, prolong circulation, selectively accumulate, specifically bind to the target, and enable controlled release in target site. Nanomaterials, such as polymeric nanoparticles, gold nanoparticles/cages/shells, and carbon nanomaterials, have the desired properties, and they can mediate therapeutic effects different from those generated by small molecule drugs (e.g., gene therapy, photothermal therapy, photodynamic therapy, and radiotherapy). This review aims to provide an overview of developing multi-modal therapies using nanomaterials ("combo" nanomedicine) along with the rationale, up-to-date progress, further considerations, and the crucial roles of interdisciplinary approaches.

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“…In a recent report, Conte et al developed NPs of amphiphilic block copolymers of poly(ε-caprolactone) (PCL) and poly(ethylene oxide) (PEO) for co-delivery of DTX and zinc-phthalocyanine (ZnPc) as a potential dual carrier system for the combination of chemotherapy and photodynamic therapy (PDT). 31 The ZnPc/DTX-loaded NPs were determined to have greater cell cytotoxicity and antitumor activity than DTX-loaded NPs, thus demonstrating a combined effect of both DTX and ZnPc.…”

Section: Drugmentioning

confidence: 98%

How nanotechnology can enhance docetaxel therapy

Zhang¹,

Zhang²

2013

IJN

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Docetaxel has been recognized as one of the most efficient anticancer drugs over the past decade; however, its poor water solubility and systemic toxicity have greatly limited its clinical application. In recent decades, the emergence of nanotechnology has provided new drug delivery systems for docetaxel, which can improve its water solubility, minimize the side effects and increase the tumor-targeting distribution by passive or active targeting. This review focuses on the research progress in nanoformulations related to docetaxel delivery -such as polymer-based, lipid-based, and lipid-polymer hybrid nanocarriers, as well as inorganic nanoparticles -addressing their structures, characteristics, preparation, physicochemical properties, methods by which drugs are loaded into them, and their in vitro and in vivo efficacies. Further, the targeted ligands used in the docetaxel nanoformulations, such as monoclonal antibodies, peptides, folic acid, transferrin, aptamers and hyaluronic acid, are described. The issues to overcome before docetaxel nanoformulations can be used in clinical and commercial applications are also discussed.

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Biodegradable core-shell nanoassemblies for the delivery of docetaxel and Zn(II)-phthalocyanine inspired by combination therapy for cancer

Cited by 104 publications

References 40 publications

Platinum covalent shell cross-linked micelles designed to deliver doxorubicin for synergistic combination cancer therapy

Platinum covalent shell cross-linked micelles designed to deliver doxorubicin for synergistic combination cancer therapy

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

How nanotechnology can enhance docetaxel therapy

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