Biodegradable Core–Shell Copolymer-Phospholipid Nanoparticles for Combination Chemotherapy: An &lt;I&gt;In&lt;/I&gt; &lt;I&gt;Vitro&lt;/I&gt; Study

Wei-cheng, MA; Xu, Airen; Ying, Jingyan; Li, Bo; Jin, Yi

doi:10.1166/jbn.2015.2059

Cited by 19 publications

(8 citation statements)

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“…Simultaneous photodynamic/photothermal therapy (PDT/PTT) is more advantageous than peak-levelled lipid assembled combined chemotherapy because it is less invasive. The drug doxorubicin was shown to enhance the localization of the hybrid form of lipid NPs, leading to greater toxicity along with many beneficial effects 24 .…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: In vitro evaluation of the toxic effects of MgO nanostructure in Hela cell line

Akram

Fakhar-e-Alam

Butt

et al. 2018

Sci Rep

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MgO is an attractive choice for carcinogenic cell destruction in photodynamic therapy, as confirmed by manifold analysis. The prime focus of the presented research is to investigate the toxicity caused by morphologically different MgO nanostructures obtained by annealing at various annealing temperatures. Smart (stimuli-responsive) MgO nanomaterials are a very promising class of nanomaterials, and their properties can be controlled by altering their size, morphology, or other relevant characteristics. The samples investigated here were grown by the co-precipitation technique. Toxicity-dependent parameters were assessed in a HeLa cell model after annealing the grown samples at 350 °C, 450 °C, and 550 °C. After the overall characterization, an analysis of toxicity caused by changes in the MgO nanostructure morphology was tested in a HeLa cell model using a neutral red assay and microscopy. The feasibility of using MgO for PDT was assessed. Empirical modelling was applied to corroborate the experimental results obtained from assessing cell viability losses and reactive oxygen species. The results indicate that MgO is an excellent candidate material for medical applications and could be utilized for its potential ability to upgrade conventionally used techniques.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: In vitro evaluation of the toxic effects of MgO nanostructure in Hela cell line

Akram

Fakhar-e-Alam

Butt

et al. 2018

Sci Rep

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“…It is worth mentioning that we have previously reported on the different cell lines that were labeled with ZnO nanomaterials with different sizes and morphologies, for example, zinc oxide nanorods (ZnO nanorods (NRs)), zinc oxide nanoparticles ZnO NPs, zinc oxide nanoporous (ZnO NP S ), zinc oxide nano flakes (ZnO nanoflakes (NFs)), zinc oxide Nanotubes (ZnO nanotubes (NTs)), and zinc oxide nano wells (ZnO nanowires (NWs)). Actually, in each of these reported cases, a new formation of cell viability loss was recorded even in the dark conditions [13,14]. In our experimental finding, a concentration of the ZnO and Fotolon, and a compatible light source along with a suitable light dose is also a very important factor for cell viability loss control.…”

Section: Resultssupporting

confidence: 54%

Empirical Modeling of Zn/ZnO Nanoparticles Decorated/Conjugated with Fotolon (Chlorine e6) Based Photodynamic Therapy towards Liver Cancer Treatment

et al. 2019

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The current study is based on Zn/ZnO nanoparticles photodynamic therapy (PDT) mediated effects on healthy liver cells and cancerous cells. The synthesis of Zn/ZnO nanoparticles was accomplished using chemical and hydrothermal methods. The characterization of the synthesized nanoparticles was carried out using manifold techniques (e.g., transmission electron microscopy (TEM), X-ray diffraction (XRD), and energy dispersive X-ray spectroscopy (EDS)). In order to study the biotoxicity of the grown nanoparticles, they were applied individually and in conjunction with the third generation photosensitiser Fotolon (Chlorine e6) in the in vivo model of the normal liver of the Wister rat, and in the in vitro cancerous liver (HepG2) model both in the dark and under a variety of laser exposures (630 nm, Ultraviolet (UV) light). The localization of ZnO nanoparticles was observed by applying fluorescence spectroscopy on a 1 cm2 selected area of normal liver, whereas the in vitro cytotoxicity and reactive oxygen species (ROS) detection were carried out by calculating the loss in the cell viability of the hepatocellular model by applying a neutral red assay (NRA). Furthermore, a statistical analysis is carried out and it is ensured that the p value is less than 0.05. Thus, the current study has highlighted the potential for applying Zn/ZnO nanoparticles in photodynamic therapy that would lead to wider medical applications to improve the efficiency of cancer treatment and its biological aspect study.

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“…Lipid assembled for combined chemotherapy is very convincing and up to the marking technique, but PDT/PTT is more favorable due to less invasiveness. This form of lipid/nanoparticle is capable to enhance the localization of drug (doxorubicin) has toxicity, but the advantage is high accumulation into nuclei [26].…”

Section: Introductionmentioning

confidence: 99%

Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

Akram

Fakhar-e-Alam

Butt

et al. 2018

Journal of Nanomaterials

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The prime focus of this investigation is to determine which morphology of magnesium oxide (MgO) is nontoxic and accumulates in sufficient quantity to a human brain cellular/tissue model. Thus, nanostructured MgO was synthesized from a coprecipitation technique involving twin synthetic protocols and the resulting product was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), size distribution histogram, Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) analysis and elemental composition was confirmed by EDX analysis. They were tested for selective antigen response in a human brain cancer model through biodistribution, biotoxicity via MTT assay, and tissue morphology. In addition, the MRI compatibility of MgO nanostructures and immunofluorescence studies were investigated on nanoconjugates with different immunoglobulins in the brain section. The results indicated that MgO had some degree of bindings with the antigens. These results led to the empirical modeling of MgO nanomaterials towards toxicity in cancer cells by analyzing the statistical data obtained by experiments. All these results are providing new rational strategy with the concept of MgO for MRI and PTT/PDT.

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Biodegradable Core–Shell Copolymer-Phospholipid Nanoparticles for Combination Chemotherapy: An <I>In</I> <I>Vitro</I> Study

Cited by 19 publications

References 0 publications

RETRACTED ARTICLE: In vitro evaluation of the toxic effects of MgO nanostructure in Hela cell line

RETRACTED ARTICLE: In vitro evaluation of the toxic effects of MgO nanostructure in Hela cell line

Empirical Modeling of Zn/ZnO Nanoparticles Decorated/Conjugated with Fotolon (Chlorine e6) Based Photodynamic Therapy towards Liver Cancer Treatment

Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

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