Biodegradable Chitosan Nanoparticle Coatings on Titanium for the Delivery of BMP-2

Poth, Nils; Seiffart, Virginia; Groß, Gerhard; Menzel, Henning; Dempwolf, Wibke

doi:10.3390/biom5010003

Cited by 72 publications

(62 citation statements)

References 54 publications

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“…Chitosan nanoparticles have characteristics like pH sensitivity, biocompatibility, and low toxicity, making them a promising candidate for new controlled release drug systems development. An interesting chitosan nanoparticles feature is the possibility to carry hydrophilic drugs such as peptides and proteins due to their hydrophilic character (Piras et al 2015;Poth et al 2015;Hecq et al 2015). Another relevant characteristic is the positively charged chitosan nanoparticle surface, which promotes electrostatic interaction with biological membranes that are negatively charged and improvement in nanoparticle stability in the presence of biological cations (Agnihotri et al 2004;Laranjeira and Fávere 2009).…”

Section: Introductionmentioning

confidence: 99%

Chitosan nanoparticles as a modified diclofenac drug release system

et al. 2017

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This study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% (w/v) by template polymerization method using methacrylic acid in aqueous solution. Chitosanpoly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50-100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% (w/v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% (w/v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and obeyed Korsmeyer-Peppas model, which was characterized mainly by Fickian diffusion transport.

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Section: Introductionmentioning

confidence: 99%

Chitosan nanoparticles as a modified diclofenac drug release system

et al. 2017

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“…The biological activity of an incorporated BMP-2 was observed in an in vivo study in mice. The results showed that biodegradable CS-TPP coatings can be employed to present biologically active BMP-2 on usual implants 54 . A layer-by-layer technique has been established to formulate a stable BMP loaded or collagen/hyaluronic acid (Col/HA) polyelectrolyte multilayer (PEM) film on titanium coating to enhance osseointegration.…”

Section: Surface Coating For Osseointegrationmentioning

confidence: 97%

Surface Modification of Titanium and its Alloys for the Enhancement of Osseointegration in Orthopaedics

John

Jaganathan²,

Supriyanto³

et al. 2016

Current Science

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Titanium (Ti) and Ti-based alloys are the best promising orthopaedic metal transplants. The Young's modulus of Ti and bone are nearer and so Ti implants are known as osseointegrated implants. However, the need for enhancing the osseointegration, corrosion resistance and biocompatibility cannot be ruled out in promoting the Ti as a golden standard. This review describes various surface modifications like acid etching, sand blasting, surface coating, alkali-heat treatment, plasma treatment and ion implantation of Ti-based implants which are the best solutions to promote biocompatibility, osseointegration and ultimately the longevity of implants. In addition, it gives an outline to accomplish the risky task in orthopaedics like recovering skeletal function by replacing the damaged bone for human being survival and it will assist the energetic collaboration of specialists in materials science, chemistry and biology for the quality enhancement.

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“…e natural high molecular polymers mainly include heparin [28], chitosan [29], gelatin [30], and albumin [31], while synthetic high molecular polymers are mainly polylactic acid (PLA), poly(lactic-co-glycolic acid) (PLGA), and polycaprolactone (PCL). Nanoparticles can be easily modified to increase their targeting capability.…”

Section: Nanoparticlesmentioning

confidence: 99%

The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment

Xiong

et al. 2019

BioMed Research International

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Antitumor therapy using a combination of drugs has shown increased clinical efficacy. Active constituents derived from plants can offer several advantages, such as high efficiacy, low toxicity, extensive effects, and multiple targets. At present, the combination of plants’ active constituents and chemotherapeutic drugs has attracted increased attention. Nanodrug delivery systems (NDDSs) have been widely used in tumor-targeted therapy because of their efficacy of delivering antitumor drugs. The in vivo process of tumor-targeted NDDSs has several steps. They include blood circulation, tumor accumulation and penetration, target cell internalization and uptake, and drug release and drug response. In each step, NDDSs encounter multiple barriers that prevent their effective delivery to target sites. Studies have been performed to find alternative strategies to overcome these barriers. We reviewed the recent progress of codelivery of active constituents of plants and chemotherapeutics using NDDSs. Progress into transversing the physiological barriers for more effective in vivo antitumor delivery will be discussed in this review.

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Biodegradable Chitosan Nanoparticle Coatings on Titanium for the Delivery of BMP-2

Cited by 72 publications

References 54 publications

Chitosan nanoparticles as a modified diclofenac drug release system

Chitosan nanoparticles as a modified diclofenac drug release system

Surface Modification of Titanium and its Alloys for the Enhancement of Osseointegration in Orthopaedics

The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment

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