Biodegradable Chitosan-Based Ambroxol Hydrochloride Microspheres: Effect of Cross-Linking Agents

Gangurde, Hemant H; Chavan, N.V.; Mundada, Atishkumar S.; Derle, Dilip; Sengodan, Tamizharasi

doi:10.4103/0975-1483.76414

Cited by 11 publications

(12 citation statements)

References 17 publications

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“…BER pathway plays a key role in repairing DNA damage due to cellular metabolism and consists of multiple enzyme systems , the XRCC1 is one of rate‐limiting members of BER and interacts with other proteins involved in several stages of the BER pathways, including repairing specific base damage caused by oxaliplatin . Patients with XRCC1 Arg399Gln (G → A) G/G genotype showed enhanced respond to oxaliplatin‐based chemotherapy compared to those with G/A + A/A in advanced CRC .…”

Section: Discussionmentioning

confidence: 99%

Predictive value of ERCC1, ERCC2, and XRCC1 overexpression for stage III colorectal cancer patients receiving FOLFOX-4 adjuvant chemotherapy

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Predictive value of ERCC1, ERCC2, and XRCC1 overexpression for stage III colorectal cancer patients receiving FOLFOX-4 adjuvant chemotherapy

et al. 2013

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“…In this case, a Schiff base reaction between amine and aldehyde occurs and as a result, chitosan chains are covalently cross-linked by the glutaraldehyde molecules. With the same mechanism, other aldehydes such as glyoxal and formaldehyde are able to crosslink chitosan chains [101][102][103]. Glutaraldehyde has been highly used also for alginate reticulation.…”

Section: Chemical Gelationmentioning

confidence: 99%

Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery

et al. 2020

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Polysaccharide-based hydrogel particles (PbHPs) are very promising carriers aiming to control and target the release of drugs with different physico-chemical properties. Such delivery systems can offer benefits through the proper encapsulation of many drugs (non-steroidal and steroidal anti-inflammatory drugs, antibiotics, etc) ensuring their proper release and targeting. This review discusses the different phases involved in the production of PbHPs in pharmaceutical technology, such as droplet formation (SOL phase), sol-gel transition of the droplets (GEL phase) and drying, as well as the different methods available for droplet production with a special focus on prilling technique. In addition, an overview of the various droplet gelation methods with particular emphasis on ionic cross-linking of several polysaccharides enabling the formation of particles with inner highly porous network or nanofibrillar structure is given. Moreover, a detailed survey of the different inner texture, in xerogels, cryogels or aerogels, each with specific arrangement and properties, which can be obtained with different drying methods, is presented. Various case studies are reported to highlight the most appropriate application of such systems in pharmaceutical field. We also describe the challenges to be faced for the breakthrough towards clinic studies and, finally, the market, focusing on the useful approach of safety-by-design (SbD).

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“…The samples were prepared as potassium bromide (KBr) disks on an FTIR spectrophotometer (2 mg sample in 200 mg KBr ratio) and scanned in a range 400-4000/cm as described earlier. [14] …”

Section: Fourier Transform Infrared (Ftir) Spectroscopymentioning

confidence: 99%

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Taksande¹

2017

AJP

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Aim: Due to the presence of rich blood circulation and non-invasive nature of administration, the nasal route has been established as valuable therapeutic alternatives. This study was designed with the basic objective to formulate mucoadhesive microspheres of anticonvulsant drug, lamotrigine (LT) for intranasal delivery and to carry out its pharmacodynamic investigations to benefit the emergency cases of epileptic seizures. Materials and Methods:The microspheres were prepared by ionotropic gelation method and characterized for morphology scanning electron microscopy, particle size, drug entrapment efficiency, thermal behavior (differential scanning calorimetry), and crystallinity (X-ray diffraction), in vitro swelling studies, in vitro drug diffusion, ex vivo bioadhesion, and ex vivo biocompatibility studies in excised sheep nasal mucosa. The resultant LT loaded chitosan (CH) microspheres were further evaluated for pharmacodynamic efficacy in pentylenetetrazol (PTZ) induced seizures in mice. Result and Discussion: Results demonstrated that the microspheres were discrete, smooth, and spherical in shape with size 24.5 ± 2.62 to 48.52 ± 2.34 µm, appropriate for nasal drug delivery. The CH-based nasal LT microspheres demonstrated high encapsulation efficacy, strong bioadhesion potential, and high permeation without any signs of morphological toxicity in excised sheep nasal mucosa. Importantly the intranasal administration of LT microspheres delayed the onset of clonic convulsion and offered complete protection against the PTZ induced seizures in mice compared to its peripheral administration. Conclusion: Thus, the formulation of LT loaded CH mucoadhesive microspheres offers promising advantages over conventional dosage with its immediate onset of action.

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Biodegradable Chitosan-Based Ambroxol Hydrochloride Microspheres: Effect of Cross-Linking Agents

Cited by 11 publications

References 17 publications

Predictive value of ERCC1, ERCC2, and XRCC1 overexpression for stage III colorectal cancer patients receiving FOLFOX-4 adjuvant chemotherapy

Predictive value of ERCC1, ERCC2, and XRCC1 overexpression for stage III colorectal cancer patients receiving FOLFOX-4 adjuvant chemotherapy

Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery

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