Biodegradable CaMgZn bulk metallic glass for potential skeletal application

Wang, Y.B.; Xie, Xinhui; Li, H.F.; Wang, X.L.; Zhao, Ming; Zhang, E.W.; Bai, Yanjie; Zheng, Yufeng; Qin, Ling

doi:10.1016/j.actbio.2011.04.027

Cited by 132 publications

(72 citation statements)

References 62 publications

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“…Obtained results can be confirmed by results reported by Wang et al [11] who examined by XRD method the corrosion products of Ca 65 Mg 15 Zn 20 glass after immersion in Hank's solution. The detected phases were mainly composed of calcium phosphate, calcium hydroxide, magnesium hydroxide, zinc hydroxide, calcium zinc hydroxide hydrate.…”

Section: R Babilas Et Alsupporting

confidence: 87%

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Electrochemical Characterization of Ca₆₅Mg₁₅Zn₂₀ Amorphous Alloy in Selected Physiological Fluids

et al. 2018

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The corrosion behavior of the bulk glassy samples of Ca65Mg15Zn20 alloy was studied by electrochemical measurements and immersion tests in a simulated body fluid, physiological fluid, and the Ringer solution. The results of immersion show that the volume of H2 evolved after 2 h in simulated body fluid (29.8 ml/cm 2 q is the highest in comparison with the results of measurements conducted in physiological fluid (11.3 ml/cm 2 q and the Ringer solution (7.4 ml/cm 2 q. The electrochemical measurements indicated a shift of the corrosion potential (Ecorrq from -1.58 V for plate tested in a physiological fluid to -1.56 V and -1.54 V for samples immersed in the Ringer solution and simulated body fluid, adequately. The X-ray diffraction measurements were used to determine composition of corrosion products. The corrosion products were mainly identified to be calcium carbonates and calcium/magnesium hydroxides.

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Section: R Babilas Et Alsupporting

confidence: 87%

“…Based on the XRD results and data presented in [11], the main corrosion reactions in selected fluids (1-6) were listed below…”

Section: R Babilas Et Almentioning

confidence: 99%

Electrochemical Characterization of Ca₆₅Mg₁₅Zn₂₀ Amorphous Alloy in Selected Physiological Fluids

et al. 2018

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“…12 As mentioned, they are quite frequently used for the examination of different biomaterials. [13][14][15][16] (2) U2OS was the first cell line to be established from an osteosarcoma in 1964 (e.g., Pautke et al 17 ). U2OS cells are also not able to differentiate and form a calcified matrix.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the reaction of bone-derived cells to enhanced MgCl₂-salt concentrations

et al. 2014

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Magnesium-based implants exhibit various advantages such as biodegradability and potential for enhanced in vivo bone formation. However, the cellular mechanisms behind this possible osteoconductivity remain unclear. To determine whether high local magnesium concentrations can be osteoconductive and exclude other environmental factors that occur during the degradation of magnesium implants, magnesium salt (MgCl 2 ) was used as a model system. Because cell lines are preferred targets in studies of non-degradable implant materials, we performed a comparative study of 3 osteosarcoma-derived cell lines (MG63, SaoS2 and U2OS) with primary human osteoblasts. The correlation among cell count, viability, cell size and several MgCl 2 concentrations was used to examine the influence of magnesium on proliferation in vitro. Moreover, bone metabolism alterations during proliferation were investigated by analyzing the expression of genes involved in osteogenesis. It was observed that for all cell types, the cell count decreases at concentrations above 10 mM MgCl 2 . However, detailed analysis showed that MgCl 2 has a relevant but very diverse influence on proliferation and bone metabolism, depending on the cell type. Only for primary cells was a clear stimulating effect observed. Therefore, reliable results demonstrating the osteoconductivity of magnesium implants can only be achieved with primary osteoblasts.

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“…[ 69 ] Further exploration of the composition space revealed Ca-rich alloys with signifi cantly increased casting diameters, and improved thermoplastic processing properties, excellent cell proliferation, and increased bone hyperplasia. [ 72,75,76 ] While the Young's modulus of the ternary systems is almost identical to that of dense cortical bone (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), the strengths are not as impressive as the Mg-rich systems, exhibiting failure in compression at around 400 MPa. Despite very limited H 2 evolution, the corrosion of the ternary alloys is very rapid, with some of the Ca-rich alloy pins dissolving completely within just 3 h. [ 75 ] Recently however, it has been demonstrated that additional alloying elements such a Yb and Sr can signifi cantly reduce the corrosion rate of the Ca-rich systems (Figure 4 ), bringing it signifi cantly below crystalline Mg-alloys, and suggesting a viable alternative to the smallerdiameter Mg-rich systems.…”

Section: Glassy Magnesium Alloysmentioning

confidence: 97%

“…[ 69,70 ] Cytotoxicity testing revealed that alloy samples were able to support signifi cant cellular activity to a high degree against a control, with increased cell viabilities up to 90%, (compared to 60% for crystalline Mg alloys), while a stimulatory effect on the rate of bone growth is also reported. [ 66,67,71,72 ] Despite such promising characteristics, the alloys must overcome some critical stumbling blocks to be seriously considered for clinical purposes. Critical casting diameters of the initial MgZnCa alloys were capped at 3 mm, potentially restricting use to small pins and screws.…”

Section: Glassy Magnesium Alloysmentioning

confidence: 99%

Bulk Metallic Glasses for Implantable Medical Devices and Surgical Tools

et al. 2016

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Their inherent lack of dislocations and hence slip planes leads to exceptionally high strength and elasticity, approaching the theoretical limit. While oxide glasses and ceramics exhibit low toughness and brittle failure, BMGs can display toughness comparable to crystalline metals. [ 2 ] The lack of grain structure means that BMGs are homogeneous and exhibit isotropic behavior, even at sub-micrometer length scales, and, without grain boundaries or precipitates as oxidation sites, corrosion rates are significantly reduced compared to conventional metals.BMGs soften above an alloy-specifi c glass-transition temperature ( T g ) before eventual, time-dependent, crystallization at a higher, crystallization temperature ( T x ). In this supercooled liquid region (SCLR) between T g and T x , the viscous BMGs may be plastically shaped under low applied forces using polymer-processing techniques, such as hot embossing, extrusion, foaming, and injection and blow moulding, before again cooling to a solid metallic glass. With relatively low processing temperatures and no solidifi cation shrinkage, parts can be formed to netshape with excellent accuracy, and geometries, and surface patterns previously diffi cult in metals can be achieved with ease. [3][4][5][6][7] Such remarkable properties and behavior have led to significant interest in BMGs as engineering materials over the past 20 years, but it is only recently that their potential for use as a biomaterial has been studied. [ 8 ] To date, our understanding of material biocompatiblity has evolved mainly through empirical testing, observing the interaction of materials with cells and host tissue in vitro and in vivo. Materials can induce host responses varying from local and systemic infl ammation, hypersensistivity, toxicity, and even tumorogenesis, meaning that thorough evidence of material safety is required before regulatory approval and clinical translation. We now largely recognise the material characteristics that generate both favorable and undesired host responses, as outlined by Williams, [ 9 ] offering the opportunity for informed material design, while being cognisant that biocompatibility is specifi c to the application and host environment. [ 10 ] The original requirement of fi rst generation "biocompatible" materials was bio-inertness. [ 11 ] This included a resistance to corrosion in the body, and here Ti-and Co-based alloys scored highly. [ 12 ] Less-inert metals, such as Mg, were therefore not deemed suitable, although the ions released on dissolution are generally not harmful to the human body. However, current design requirements for biomaterials, including most recently biometals, include eliciting an appropriate host response, [ 13 ] and this can include the need to biodegrade and resorb. There are potential advantages for BMGs that span applications of With increasing knowledge of the materials science of bulk metallic glasses (BMGs) and improvements in their properties and processing, they have started to become candidate materials for biomedical dev...

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Biodegradable CaMgZn bulk metallic glass for potential skeletal application

Cited by 132 publications

References 62 publications

Electrochemical Characterization of Ca₆₅Mg₁₅Zn₂₀ Amorphous Alloy in Selected Physiological Fluids

Electrochemical Characterization of Ca₆₅Mg₁₅Zn₂₀ Amorphous Alloy in Selected Physiological Fluids

Comparison of the reaction of bone-derived cells to enhanced MgCl₂-salt concentrations

Bulk Metallic Glasses for Implantable Medical Devices and Surgical Tools

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Biodegradable CaMgZn bulk metallic glass for potential skeletal application

Cited by 132 publications

References 62 publications

Electrochemical Characterization of Ca65Mg15Zn20 Amorphous Alloy in Selected Physiological Fluids

Electrochemical Characterization of Ca65Mg15Zn20 Amorphous Alloy in Selected Physiological Fluids

Comparison of the reaction of bone-derived cells to enhanced MgCl2-salt concentrations

Bulk Metallic Glasses for Implantable Medical Devices and Surgical Tools

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Electrochemical Characterization of Ca₆₅Mg₁₅Zn₂₀ Amorphous Alloy in Selected Physiological Fluids

Electrochemical Characterization of Ca₆₅Mg₁₅Zn₂₀ Amorphous Alloy in Selected Physiological Fluids

Comparison of the reaction of bone-derived cells to enhanced MgCl₂-salt concentrations