Biodegradable Black‐Phosphorus‐Nanosheet‐Based Nanoagent for Enhanced Chemo‐Photothermal Therapy

Abstract

Black phosphorus nanosheet (BPNS) is a promising multifunctional material in the biomedical field with biodegradability and low side effects, however its features are always weakened severely owing to its poor stability. Here, a novel method is developed for improving the defect of BPNS based on the effective protection of poly(lactic‐co‐glycolic acid) (PLGA), which preserves the stable photothermal therapy (PTT) effect of BPNS and biodegradability of the material. Meanwhile, doxorubicin (DOX) is loaded on BPNS/PLGA to get BPNS/PLGA/DOX for further chemotherapy and preventing the recurrence of tumor after PTT. The presented combined therapeutic strategy exploits the strengths and improves the defects of BPNS, thus developing an efficient and safe nanoagent for cancer therapy, which affords and reveals the great potential of BPNS in nanomedicine.

Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials

“…In addition, several studies have confirmed that they exhibit biodegradable and compatible nature to avoid toxicity in vivo. [253,[259][260][261] These properties give BPNSs great potential in the field of biomedicine. At present, BPNSs have become one of the hottest 2D nanomaterials for the treatment of AD.…”

Chemical degradation kinetics for two-dimensional materials in natural and biological environments – a data-driven review

“…Articles actively used in the preparation of this review article are cited in the reference section. 3,4,13–21,23–28,30–137 The data was selected in a time-blind manner, i.e. dependent only on the suitability of the data without prioritizing the year the data was published.…”

Does black phosphorus hold potential to overcome graphene oxide? A comparative review of their promising application for cancer therapy

“…As it has been previously described in section 2, other different processes have been explored to protect NBP; namely physical and chemical strategies. 72 Polymer capping such as poly(lactic-co-glycolic acid), 73 or polyethylenimine (PEI) 74 have also been used to prolong the shelf life of the material and for the design of efficient phototherapeutic/drug delivery NBP-based platforms. In conclusion, while the surface of GO is chemically modified to enhance its biodegradation ability, 58,75 NBP is normally functionalised to slow down its degradation rate, making it a more stable material.…”