Biodegradable bioadhesive nanoparticle incorporation of broad‐spectrum organic sunscreen agents

Abstract

Conventional emulsion‐based sunscreen formulations are limited by postapplication epicutaneous penetration that increases the risk of allergic dermatitis, cellular damage, and filter photodegradation upon ultraviolet radiation (UVR) exposure. Encapsulation of the UVB filter padimate O within bioadhesive biodegradable nanoparticles (BNPs) composed of poly(d,l‐lactic acid)‐hyperbranched polyglycerol was previously shown to enhance UVR protection while preventing skin absorption. Herein, we assess the capacity of BNP co‐incorporation of avobenzone and octocrylene to provide broad‐spectrum UVR protection. The ratio of UV filters within nanoparticles (NPs) was optimized for filter–filter stabilization upon UV irradiation and maximum drug loading. In vitro water‐resistance test showed significant particle retention at 85% over 3 hr. In a pilot clinical study, protection against UVR‐induced erythema of BNPs was found to be comparable to the FDA standard P2. Thus, sunscreen formulations utilizing BNP incorporation of a combination of organic filters may offer key safety and performance advantages.

Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles

“…corneum (20), mesenteric membranes (18), vaginal epithelium (21), and intracranial tumor cells (19). We have also shown that BNPs, applied as a topical sunscreen, can prevent the double-stranded DNA breaks associated with cutaneous carcinogenesis, while at the same time minimizing the systemic accumulation of ultraviolet filters common to commercially available sunscreens (20,22). For these reasons, we studied the potential role for BNP in a well-characterized, transplantable PDV SCC tumor murine model (23).…”

UVA-Triggered Drug Release and Photo-Protection of Skin

“…Photolysis of the dyad in a hydrogen-donor solvent resulted in simultaneous release of diclofenac and avobenzone. Another study from Suh et al ( 2019 ) formulated a smart sunscreen by encapsulating padimate O UVB filters within biodegradable nanoparticles BNPs consisted of poly( D,L -lactic acid)-hyperbranched polyglycerol containing avobenzone and octocrylene. This study found that the incorporation of a UV filter within nanoparticles offered filter stabilization and optimized drug release upon UV irradiation.…”

Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

“…NPs are composed of a block copolymer of poly(lactic acid) and hyperbranched polyglycerol (PLA-HPG), which can be surface-functionalized to introduce aldehyde (CHO) groups ( 35 ), creating PLA-HPG-CHO that confers several advantages for the delivery of PNA anti-miRs. NPs formed from PLA-HPG-CHO are bioadhesive NPs (BNPs) ( 36 , 37 ). We have shown that, compared with several other NPs of similar composition, these BNPs lead to the highest level of uptake into intracranial tumor cells after CED ( 38 ), and they can be loaded with PNAs, which are slowly released in the brain after CED ( 18 ).…”