Biodegradable, Bioactive-Based Poly(anhydride-esters) for Personal Care and Cosmetic Applications

Carbone-Howell, Ashley L.; Ouimet, Michelle A.; Uhrich, Kathryn E.

doi:10.1021/bk-2013-1148.ch009

Cited by 2 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SAPAEs contain salicylic acid, the primary active metabolite of aspirin, 24,25 incorporated within the polymer backbone and exhibit controlled SA release as the polymer undergoes hydrolytic degradation via a surface-eroding mechanism. 2,17,18,24,26 Salicylic acid not only is a potent nonsteroidal anti-inflammatory drug (NSAID), 7,27 but also exhibits a multitude of beneficial behaviors, including antibacterial, 28 antifungal, 29 antioxidant, 30 and keratolytic activities, 31,32 extending potential application of SAPAEs beyond just in vivo therapeutic use to include coatings and topical applications. 14,33 Chemical incorporation of SA into the polymer backbone is advantageous because much higher SA loadings (~75%) can be achieved compared to conventional physical encapsulation methods, and since the polymer is composed of water-sensitive anhydride and ester bonds, degradation can be effectively triggered by the presence of water.…”

Section: Introductionmentioning

confidence: 99%

Effect of pH on salicylic acid-based poly(anhydride-ester): Implications for polymer degradation and controlled salicylic acid release

Gulrajani

Snyder

Hackenberg

et al. 2022

Journal of Bioactive and Compatible Polymers

View full text Add to dashboard Cite

Salicylic acid (SA)-based poly(anhydride-esters) (SAPAEs) hydrolytically degrade to release SA in a controlled manner over extended time periods. While these polymers have been well investigated under in vivo conditions, this study is the first detailed, systematic assessment of in vitro polymer degradation over a range of pH values. To investigate the effect of pH conditions on SAPAE degradation, in vitro degradation studies were conducted on SAPAE disks over a wide pH range (2.0, 4.0, 6.0, 7.4, 8.0, 9.0, and 10.0) for 30 days. Several parameters were evaluated, including SA concentrations in the degradation media, polymer mass loss, water uptake in the polymer matrices, and SA solubility at different pH values to substantiate SA release results and characterize the in vitro polymer degradation process. Complete SA release was achieved at more basic conditions (pH 9.0 and 10.0) over 9 days, whereas less than 41% SA was released over the same time period at neutral pH conditions (pH 8.0 and 7.4). By comparison, SA release was minimal in acidic pH conditions. Overall, we present quantitative data of polymer degradation as defined by SA in vitro release, which increased with increasing pH values. More basic conditions promoted polymer degradation, whereas acidic conditions minimized polymer degradation.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of pH on salicylic acid-based poly(anhydride-ester): Implications for polymer degradation and controlled salicylic acid release

Gulrajani

Snyder

Hackenberg

et al. 2022

Journal of Bioactive and Compatible Polymers

View full text Add to dashboard Cite

show abstract

“…Biodegradable polymer microspheres have been extensively investigated as potential carriers for drugs, − cosmetic products, − delivery systems, and for diagnostic purposes because of their biocompatibility, biodegradability, stability, and sustained-release properties. , Among the most studied materials for encapsulation are derivatives of poly( d , l -lactide), poly( d , l -lactide- co -glycolide) (PLGA), and poly-ε-caprolactones, and the most widespread mechanism for encapsulation with them is the total enfold of the molecule of interest by the polymeric thin film to generate a spherical microparticle.…”

Section: Introductionmentioning

confidence: 99%

Single-Emulsion P(HB-HV) Microsphere Preparation Tuned by Copolymer Molar Mass and Additive Interaction

2019

View full text Add to dashboard Cite

Herein, we describe the production of poly(hydroxybutyrate- co -hydroxyvalerate) [P(HB-HV)]-based microspheres containing coumarin-6 (C6) or pyrene (Py) fluorophores as additives and models for hydrophobic and hydrophilic drug encapsulation. Their photophysical and morphological properties, as well as encapsulation efficiencies, are studied as this work aims to describe the influence of additive hydrophobicity/hydrophilicity on microparticle formation. These properties were studied by scanning electron microscopy, fluorescence confocal laser scanning microscopy (FCLSM), and steady-state fluorescence spectroscopy. The results show that the surfactant concentration, polymer molar mass, emulsification stirring rate, and the presence of the fluorophore and its nature are determinants of the P(HB-HV) microsphere properties. Also, encapsulation efficiency is shown to be governed by synergic effects of these parameters on the formation of microspheres. Moreover, size distribution is proved to be strongly influenced by the surfactant poly(vinyl alcohol) content. FCLSM showed that the fluorophores were efficiently encapsulated in P(HB-HV) microspheres at distinct distributions within the copolymer matrix. Surprisingly, nanospheres were observed in the microsphere surface, suggesting that microspheres are formed from nanosphere coalescence.

show abstract

Biodegradable, Bioactive-Based Poly(anhydride-esters) for Personal Care and Cosmetic Applications

Cited by 2 publications

References 39 publications

Effect of pH on salicylic acid-based poly(anhydride-ester): Implications for polymer degradation and controlled salicylic acid release

Effect of pH on salicylic acid-based poly(anhydride-ester): Implications for polymer degradation and controlled salicylic acid release

Single-Emulsion P(HB-HV) Microsphere Preparation Tuned by Copolymer Molar Mass and Additive Interaction

Contact Info

Product

Resources

About