Biodegradable and flexible arterial-pulse sensor for the wireless monitoring of blood flow

Boutry, Clémentine M.; Beker, Levent; Kaizawa, Yukitoshi; Vassos, Christopher; Tran, Helen; Hinckley, Allison C.; Pfattner, Raphael; Niu, Simiao; Li, Junheng; Claverie, Jean; Wang, Zhen; Chang, James; Fox, Paige M.; Bao, Zhenan

doi:10.1038/s41551-018-0336-5

Cited by 647 publications

(652 citation statements)

References 50 publications

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“…Despite this requirement, the development of implantable electronics often lacks functional interrogation distances and relies on slow, low-throughput fabrication procedures. [6,7] Currently, an implantable pressure sensor is commercially available, but consists of a bulky, rigid electronics package intended for pressure sensing in larger diameter blood vessels. Many current wearable and implantable electronics still rely on rigid circuitry to enable wireless interrogation.…”

Section: Introductionmentioning

confidence: 99%

Fully Printed, Wireless, Stretchable Implantable Biosystem toward Batteryless, Real‐Time Monitoring of Cerebral Aneurysm Hemodynamics

et al. 2019

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This study introduces a high‐throughput, large‐scale manufacturing method that uses aerosol jet 3D printing for a fully printed stretchable, wireless electronics. A comprehensive study of nanoink preparation and parameter optimization enables a low‐profile, multilayer printing of a high‐performance, capacitance flow sensor. The core printing process involves direct, microstructured patterning of biocompatible silver nanoparticles and polyimide. The optimized fabrication approach allows for transfer of highly conductive, patterned silver nanoparticle films to a soft elastomeric substrate. Stretchable mechanics modeling and seamless integration with an implantable stent display a highly stretchable and flexible sensor, deployable by a catheter for extremely low‐profile, conformal insertion in a blood vessel. Optimization of a transient, wireless inductive coupling method allows for wireless detection of biomimetic cerebral aneurysm hemodynamics with the maximum readout distance of 6 cm through meat. In vitro demonstrations include wireless monitoring of flow rates (0.05–1 m s−1) in highly contoured and narrow human neurovascular models. Collectively, this work shows the potential of the printed biosystem to offer a high throughput, additive manufacturing of stretchable electronics with advances toward batteryless, real‐time wireless monitoring of cerebral aneurysm hemodynamics.

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Section: Introductionmentioning

confidence: 99%

Fully Printed, Wireless, Stretchable Implantable Biosystem toward Batteryless, Real‐Time Monitoring of Cerebral Aneurysm Hemodynamics

et al. 2019

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“…Representative examples of physical sensors. a) Left: Sketch of the structure and functional principle of the wireless‐readable capacitive pressure sensor . Middle: Sketch of the in vivo inductively coupled measurement setup.…”

Section: Bioresorbable Electrical Devicesmentioning

confidence: 99%

Section: Bioresorbable Electrical Devicesmentioning

confidence: 99%

“…In another recent work of the same group, a miniaturized capacitive pressure sensor with slightly different geometry was implanted in rat around the femoral artery, and heart rate was wirelessly measured on‐demand, exploiting RF coupling to monitor LCR resonant circuit frequency shift . Namely, PHB/PHV and POMaC (thickness of 10 µm each) were used as bottom and top substrate, respectively, laser‐cut magnesium foil (50 µm) was used for inductive coil antenna and fringe‐field capacitor metal traces, PLLA (40 µm) was inserted as coil spacer, and micropatterned PGS (40 µm) acted as dielectric (Figure a).…”

Section: Bioresorbable Electrical Devicesmentioning

confidence: 99%

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Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

2020

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Over the last decade, scientists have dreamed about the development of a bioresorbable technology that exploits a new class of electrical, optical, and sensing components able to operate in physiological conditions for a prescribed time and then disappear, being made of materials that fully dissolve in vivo with biologically benign byproducts upon external stimulation. The final goal is to engineer these components into transient implantable systems that directly interact with organs, tissues, and biofluids in real‐time, retrieve clinical parameters, and provide therapeutic actions tailored to the disease and patient clinical evolution, and then biodegrade without the need for device‐retrieving surgery that may cause tissue lesion or infection. Here, the major results achieved in bioresorbable technology are critically reviewed, with a bottom‐up approach that starts from a rational analysis of dissolution chemistry and kinetics, and biocompatibility of bioresorbable materials, then moves to in vivo performance and stability of electrical and optical bioresorbable components, and eventually focuses on the integration of such components into bioresorbable systems for clinically relevant applications. Finally, the technology readiness levels (TRLs) achieved for the different bioresorbable devices and systems are assessed, hence the open challenges are analyzed and future directions for advancing the technology are envisaged.

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“…Various implantable devices are developed for healthcare monitoring purpose, such as chemical sensors to detect glucose and lactate, [1,2] flexible electronics to record electrophysiological signals, [3] optoelectronic photometers to monitor neuronal dynamics, [4] and pressure sensors for blood flow monitoring [5] and orthopedic applications. Various implantable devices are developed for healthcare monitoring purpose, such as chemical sensors to detect glucose and lactate, [1,2] flexible electronics to record electrophysiological signals, [3] optoelectronic photometers to monitor neuronal dynamics, [4] and pressure sensors for blood flow monitoring [5] and orthopedic applications.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Low‐Current Direct Stimulation for Rehabilitation Treatment Related to Muscle Function Loss Using Self‐Powered TENG System

et al. 2019

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Muscle function loss is characterized as abnormal or completely lost muscle capabilities, and it can result from neurological disorders or nerve injuries. The currently available clinical treatment is to electrically stimulate the diseased muscles. Here, a self‐powered system of a stacked‐layer triboelectric nanogenerator (TENG) and a multiple‐channel epimysial electrode to directly stimulate muscles is demonstrated. Then, the two challenges regarding direct TENG muscle stimulation are further investigated. For the first challenge of improving low‐current TENG stimulation efficiency, it is found that the optimum stimulation efficiency can be achieved by conducting a systematic mapping with a multiple‐channel epimysial electrode. The second challenge is TENG stimulation stability. It is found that the force output generated by TENGs is more stable than using the conventional square wave stimulation and enveloped high frequency stimulation. With modelling and in vivo measurements, it is confirmed that the two factors that account for the stable stimulation using TENGs are the long pulse duration and low current amplitude. The current waveform of TENGs can effectively avoid synchronous motoneuron recruitment at the two stimulation electrodes to reduce force fluctuation. Here, after investigating these two challenges, it is believed that TENG direct muscle stimulation could be used for rehabilitative and therapeutic purpose of muscle function loss treatment.

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Biodegradable and flexible arterial-pulse sensor for the wireless monitoring of blood flow

Cited by 647 publications

References 50 publications

Fully Printed, Wireless, Stretchable Implantable Biosystem toward Batteryless, Real‐Time Monitoring of Cerebral Aneurysm Hemodynamics

Fully Printed, Wireless, Stretchable Implantable Biosystem toward Batteryless, Real‐Time Monitoring of Cerebral Aneurysm Hemodynamics

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

Investigation of Low‐Current Direct Stimulation for Rehabilitation Treatment Related to Muscle Function Loss Using Self‐Powered TENG System

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