Biocorrosion behavior and cytotoxicity of a Mg–Gd–Zn–Zr alloy with long period stacking ordered structure

Zhang, Xiaobo; Wu, Yixuan; Xue, Yanjun; Wang, Zhangzhong; Yang, Lei

doi:10.1016/j.matlet.2012.07.030

Cited by 100 publications

(26 citation statements)

References 12 publications

(12 reference statements)

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“…The LPSO structure plays a very important role in the corrosion behavior of Mg alloys (Leng et al, 2013;Peng et al, 2014;Zhang, Wu, Xue, Wang, & Yang, 2012c;Zhang et al, 2014a;Zhang et al, 2015). Zhang et al (2012c) reported that corrosion rate of the as-extruded Mg-11.3Gd-2.5Zn-0.7Zr alloy with LPSO structure in SBF is only 0.17 mm/year, while that of the as-extruded Mg-10.2Gd-3.3Y-0.6Zr alloy without LPSO structure is 0.55 mm/year. Furthermore, the Mg-11.3Gd-2.5Zn-0.7Zr alloy with LPSO structure shows relatively uniform corrosion even when it has discontinuously distributed second phase ( Figure 11A).…”

Section: The Improvement Of Corrosion Behavior By Lpso Structurementioning

confidence: 99%

“…Corrosion morphologies of the as-extruded Mg-11.3Gd-2.5Zn-0.7Zr alloy with LPSO structure (A) and Mg-10.2Gd-3.3Y-0.6Zr alloy without LPSO structure (B) after immersion in Hank's solution for 120 h(Zhang et al, 2012c).Brought to you by | New York University Bobst Library Corrosion morphologies of the GZ51K alloy after immersion in SBF for 120 h heat treated at (A) 350°C, (B) 400°C, (C) 450°C, and (D) 500°C (Zhang et al, 2015). Microstructure of the GZ51K alloy heat treated at (A) 350°C, (B) 400°C, (C) 450°C, and (D) 500°C (Zhang et alCorrosion rates of GZ51K alloy under different solution temperatures after immersion in SBF for 120 h(Zhang et al, 2015).…”

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Improvement of corrosion resistance of magnesium alloys for biomedical applications

Chen¹,

Dai²,

Zhang³

2015

Corrosion Reviews

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In recent years, magnesium (Mg) alloys have attracted great attention due to superior biocompatibility, biodegradability, and other characteristics important for use in biodegradable implants. However, the development of Mg alloys for clinical application continues to be hindered by high corrosion rates and localized corrosion modes, both of which are detrimental to the mechanical integrity of a load-bearing temporary implant. To overcome these challenges, technologies have been developed to improve the corrosion resistance of Mg alloys, among which surface treatment is the most common way to enhance not only the corrosion resistance, but also the bioactivity of biodegradable Mg alloys. Nevertheless, surface treatments are unable to fundamentally solve the problems of fast corrosion rate and localized corrosion. Therefore, it is of great importance to alter and improve the intrinsic corrosion behavior of Mg alloys for biomedical applications. To show the significance of the intrinsic corrosion resistance of biodegradable Mg alloys and attract much attention on this issue, this article presents a review of the improvements made to enhance intrinsic corrosion resistance of Mg alloys in recent years through the design and preparation of the Mg alloys, including purifying, alloying, grain refinement, and heat treatment techniques. The influence of long-period stacking-ordered structure on corrosion behavior of the biodegradable Mg alloys is also discussed.

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Section: The Improvement Of Corrosion Behavior By Lpso Structurementioning

confidence: 99%

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confidence: 99%

Improvement of corrosion resistance of magnesium alloys for biomedical applications

Chen¹,

Dai²,

Zhang³

2015

Corrosion Reviews

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“…It has been proved that Gd shows better tolerability for mouse macrophages and human umbilical cord perivascular cells, and lower production of inflammatory markers than yttrium (Feyerabend et al, ). Our previous work found that the as‐extruded Mg–11.3Gd–2.5Zn–0.7Zr alloy, which contains more Gd and Zn concentration than GZ60K and GZ61K alloys herein, shows acceptable cell viability for L‐929 cells tested in 100% alloy extraction medium (Zhang, Wu, Xue, Wang, & Yang, ). Tiyyagura et al () have also reported that the pH value and Mg 2+ ion release of the Mg–5Gd alloy were 8.3 and ~62 mg/L, respectively, after 28 days immersion in SBF, resulted in a less aggressive pH environment compared to pure Mg.…”

Section: Discussionmentioning

confidence: 83%

Corrosion behavior and mechanical degradation of as‐extruded Mg–Gd–Zn–Zr alloys for orthopedic application

et al. 2019

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The microstructures, corrosion behavior, and mechanical degradation of the as‐extruded Mg–6.0Gd–0.5Zn–0.4Zr (wt %, GZ60K) and Mg–6.0Gd–1.0Zn–0.4Zr (wt %, GZ61K) alloys were investigated. In both alloys, stacking faults and precipitates are formed in the recrystallized microstructures. The corrosion rate of GZ61K calculated by the hydrogen evolution in simulated body fluid is 0.34 ± 0.13 mm/year, which is lower than that of GZ60K (0.45 ± 0.09 mm/year); and the current density of GZ61K (5.23 ± 1.41 μA cm−2) is much lower than that of GZ60K (11.95 ± 3.37 μA cm−2). The corrosion results indicate GZ61K is more resistant to corrosion than GZ60K, but GZ60K presents more uniform corrosion mode as compared to GZ61K. After immersion in simulated body fluid for 7, 14, and 21 days, a slight decrease in the strength of both alloys is observed. The yield strength half‐life is assessed for mechanical degradation and determined to be 125 and 85 days for GZ60K and GZ61K, respectively. The as‐extruded GZ60K alloy with more uniform corrosion and longer mechanical integrity shows promising potential for orthopedic application.

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“…Due to these attractive properties such as ease of machining, low density, high specific strength and materials modulus being similar to bone, and ability to degrade and safely be absorbed under physiological conditions, as compared with many other traditional metallic biomaterials. However, a difficult challenge for biomaterials is that magnesium alloys exhibit rapid corrosion rate [1][2][3][4]. Several approaches have been developed to enhance corrosion resistance, one of the effective methods is the use of alloying elements [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Effect of yttrium addition on the microstructure and corrosion resistance of Mg−Zn−Zr alloys

Jia

Han

Sun

et al. 2019

Materialwissenschaft Werkst

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Microstructure evolution and bio-corrosion behaviors of as-cast Mg-3Zn-0.4Zr-xY (x = 0, 1, 2, 3 and 4 wt.%) alloys were studied by using optical microscope, x-ray diffractometer, transmission electron microscopy, scanning electron microscope, immersion test and electrochemical measurement. Results indicated that yttrium addition led to significant grain refinement and to the formation of I-phase (Mg 3 YZn 6 ) and W-phase (Mg 3 Y 2 Zn 3 ). The volume fraction of I-phase is dramatically increased after 2 wt% yttrium addition, and the corrosion resistance is improved, while further addition reverses the effect, due to the rising W-phase, which increases the amount of cathodic sites and accelerates the galvanic corrosion process.

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Biocorrosion behavior and cytotoxicity of a Mg–Gd–Zn–Zr alloy with long period stacking ordered structure

Cited by 100 publications

References 12 publications

Improvement of corrosion resistance of magnesium alloys for biomedical applications

Improvement of corrosion resistance of magnesium alloys for biomedical applications

Corrosion behavior and mechanical degradation of as‐extruded Mg–Gd–Zn–Zr alloys for orthopedic application

Effect of yttrium addition on the microstructure and corrosion resistance of Mg−Zn−Zr alloys

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