Bioconversion potential of plant enzymes for the production of pharmaceuticals

Pras, Niesko; Woerdenbag, Herman J.; Uden, W van

doi:10.1007/bf00052165

Cited by 16 publications

(1 citation statement)

References 32 publications

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“…Different types of cell cultures (suspension and hairy root) are used to transform natural or synthetic aromatic compounds, steroids, alkaloids, coumarins, terpenoids, lignans and many other compounds through biotransformation. The biotransformation process includes reactions such as reduction, oxidation, hydroxylation, acetylation, esterification, glucosylation, isomerization, methylation, demethylation, epoxidation and many more (Pras et al 1995;Uden et al 1995;Rout et al 2000a;Giri et al 2001;Sharafi et al 2013b). Some of famous examples on pharmaceutical products obtained by biotransformation are: producing Rhaziminine from Rhazya stricta (Saeed et al 1993), Podophyllum hexandrum for Podophyllotoxin (Uden et al 1995); Mucuna prureins for DOPA (3,4-dihydroxyphenylalanine) (Pras et al 1995); Catharanthus roseus for Viincrisitne (DiCosmo and Misawa 1995), Eucalyptus perriniana for Taxol derivatives (Hamada et al 1996), Codeine (Wilhelm and Zenk 1997), Spirulina platensis for Morphine , Capsicum frutescens for Vinallin, Capsaicin and Capsicum frutescens for Digoxin and purpureaglycoside .…”

Section: Biotransformation Versus In Vitro Production Of Secondary Mementioning

confidence: 99%

In Vitro Micropropagation of Medicinal and Aromatic Plants

Máthé

Hassan

Kader

2015

Medicinal and Aromatic Plants of the World

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Modern biotechnological methods like in vitro micropropagation technique hold tremendous potential for the production of high-quality plant-based medicine. They also allow to achieve the large scale multiplication of diseasefree plants, faster cloning and the conservation of desired genotypes, in a very short span of time. Via genetic transformation techniques, the modification of both genetic information of MAPs and the regulation of genes responsible for the production of valuable biologically active substances has also become possible in either higher amounts or with better properties.Micropropagation protocols are worked out for many plant species cultured in vitro to provide macro-and micro-mineral nutrients, vitamins, source of carbohydrates, appropriate environmental conditions (light intensity, photoperiod and temperature) and plant growth regulators required to obtain high regeneration rates. As such they are expected to facilitate commercially feasible micropropagation. Well-defined cell culture methods have also been developed to produce pharmacologically important secondary metabolites. Genetic engineering is applied to produce transgenic medicinal plants and metabolites.This chapter offers a brief insight into the present status of the biotechnology of MAPs. Special emphasis has been placed on the in vitro micropropagation and rapid clonal multiplication of selected elite genotypes, the regulation of organogenesis and somatic embryogenesis, the exploitation of advantages in somaclonal variation and genetic engineering techniques for both crop improvement and in vitro germplasm conservation. The production of flavor and volatile constituents in tissue cultures will also be briefly discussed, similarly to the application of farther biotechnological approaches.

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Section: Biotransformation Versus In Vitro Production Of Secondary Mementioning

confidence: 99%

In Vitro Micropropagation of Medicinal and Aromatic Plants

Máthé

Hassan

Kader

2015

Medicinal and Aromatic Plants of the World

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Discovery and Utilization of Biocatalysts for Chiral Synthesis: An Overview of Chinese Scientists Research and Development

et al. 2009

Biotechnology in China I

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The importance of chiral issues in active pharmaceutical ingredients has been widely recognized not only by pharmacologists, but also by chemists, chemical engineers and administrators. In fact, the worldwide sales of single-enantiomer drugs have exceeded US $150 billion. Among them the contribution rate of biocatalysis technology is ever increasing (up to 15-20%). This chapter will focus on the biocatalytic synthesis of chiral compounds useful for pharmaceutical industry. Diverse enzymes, such as oxidoreductases, epoxide hydrolases, nitrilases/nitrile hydratases and hydroxy nitrile lyases which were isolated from various sources including microorganisms and plants, and the methodology for utilizing these enzymes in enantioselective or asymmetric synthesis will be discussed briefly.

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Encapsulated Plant Cells: Techniques and Applications

Su¹

1999

Cell Encapsulation Technology and Therapeutics

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Bioconversion potential of plant enzymes for the production of pharmaceuticals

Cited by 16 publications

References 32 publications

In Vitro Micropropagation of Medicinal and Aromatic Plants

In Vitro Micropropagation of Medicinal and Aromatic Plants

Discovery and Utilization of Biocatalysts for Chiral Synthesis: An Overview of Chinese Scientists Research and Development

Encapsulated Plant Cells: Techniques and Applications

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