Bioconversion of (R)-(+)-limonene by P. digitatum (NRRL 1202)

Tan, Qiang; Day, Donal F.; Cadwallader, Keith R.

doi:10.1016/s0032-9592(97)00048-4

Cited by 64 publications

(62 citation statements)

References 29 publications

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“…The proposed involvement of a P-450 monooxygenase rather than a hydratase was supported by three experimental findings; both the iron-chelating agent phenanthroline and a reduced oxygen concentration lowered the rate of aterpineol formation, while cyanide did not have any inhibitory effect (Tan et al 1998). The specific activity (less than 0.1 U/g dry weight; Tan et al 1998), however, is too low for the economical biocatalytical production of a-terpineol. Immobilization in alginate beads as described by Tan and Day (1998b) increased the stability, but did not lead to a significant improvement of the specific activity.…”

Section: Bioconversions By Fungi and Yeastsmentioning

confidence: 82%

“…No experimental details were given and no follow-up studies on this strain appeared. More recently, the formation of a-terpineol by P. digitatum NRRL 1202 was examined in more detail Day 1998a, 1998b;Tan et al 1998). The proposed involvement of a P-450 monooxygenase rather than a hydratase was supported by three experimental findings; both the iron-chelating agent phenanthroline and a reduced oxygen concentration lowered the rate of aterpineol formation, while cyanide did not have any inhibitory effect (Tan et al 1998).…”

Section: Bioconversions By Fungi and Yeastsmentioning

confidence: 99%

“…More recently, the formation of a-terpineol by P. digitatum NRRL 1202 was examined in more detail Day 1998a, 1998b;Tan et al 1998). The proposed involvement of a P-450 monooxygenase rather than a hydratase was supported by three experimental findings; both the iron-chelating agent phenanthroline and a reduced oxygen concentration lowered the rate of aterpineol formation, while cyanide did not have any inhibitory effect (Tan et al 1998). The specific activity (less than 0.1 U/g dry weight; Tan et al 1998), however, is too low for the economical biocatalytical production of a-terpineol.…”

Section: Bioconversions By Fungi and Yeastsmentioning

confidence: 99%

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Biotransformation of limonene by bacteria, fungi, yeasts, and plants

Duetz

Bouwmeester²,

Beilen

et al. 2003

Appl Microbiol Biotechnol

222

147

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The past 5 years have seen significant progress in the field of limonene biotransformation, especially with regard to the regiospecificity of microbial biocatalysts. Whereas earlier only regiospecific biocatalysts for the 1,2 position (limonene-1,2-diol) and the 8-position (a-terpineol) were available, recent reports describe microbial biocatalysts specifically hydroxylating the 3-position (isopiperitenol), 6-position (carveol and carvone), and 7-position (perillyl alcohol, perillylaaldehyde, and perillic acid). The present review also includes the considerable progress made in the characterization of plant P-450 limonene hydroxylases and the cloning of the encoding genes.

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Section: Bioconversions By Fungi and Yeastsmentioning

confidence: 82%

Section: Bioconversions By Fungi and Yeastsmentioning

confidence: 99%

Section: Bioconversions By Fungi and Yeastsmentioning

confidence: 99%

See 1 more Smart Citation

Biotransformation of limonene by bacteria, fungi, yeasts, and plants

Duetz

Bouwmeester²,

Beilen

et al. 2003

Appl Microbiol Biotechnol

222

147

View full text Add to dashboard Cite

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“…Generally, the minimum inhibitory concentration (MIC) of limonene against some bacteria and yeasts are lower than 2% (14), although some fungi, e.g. Penicillium digitatum, presents only a small reduction on its bioconversion activity in concentrations of 4-8% limonene (27) and some bacteria, e.g. Pseudomonas sp., might have no growth inhibition in concentrations of up to 10% α-or β-pinenes (32).…”

Section: Limonene Resistant Microorganismsmentioning

confidence: 99%

“…Furthermore, monoterpene toxicity might depend on their droplet size in suspension, as observed for Saccharomyces cerevisae (28). In biotransformation processes, the usual limonene concentration applied vary from 0.2 to 1% (3,10,11,22,24,27,29), although 0.2% limonene is the optimum concentration for its biotransformation to perillyl alcohol and p-ment-1-ene-6,8-diol using Pseudomonas putida (7) and is toxic to Bacillus stearothermophilus (4).…”

Section: Limonene Resistant Microorganismsmentioning

confidence: 99%

Isolation and screening of d-limonene-resistant microorganisms

Bicas

Pastore

2007

Braz. J. Microbiol.

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This study reports the isolation of microorganisms that are resistant to environment containing limonene, the most important residue in the citrus industry. For the isolation, samples collected from strategic places of a citrus processing plant (yellow water, entrance and exit of the bagasse tank, effluent and deteriorated fruits found in bins, machine straps, fruit washers and plant floor), some citrus fruit and mint from local market were used. The samples were incubated in rotary shaker at 30ºC/150rpm for 48h or 7 days in YM medium containing 0.1% limonene. Great part of the 112 strains recovered after 48h and the 126 strains recovered after 7 days were identified as Gram positive bacilli, followed by Gram negative bacilli, yeasts and Gram positive cocci, besides five fungi. About half of the Gram positive and Gram negative bacilli and yeasts and some Gram positive Cocci were resistant to limonene concentrations up to 2% in the medium broth. Amongst them seventy were able to grow in mineral medium containing limonene as sole carbon source. The research described in this paper is the initial step for the exploration of flavor compounds production via biotransformation of limonene, a nonexpensive by-product of citrus industry.

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