Biocontrol through antibiosis: exploring the role played by subinhibitory concentrations of antibiotics in soil and their impact on plant pathogens

Arseneault, Tanya; Filion, Martin

doi:10.1080/07060661.2017.1354335

Cited by 32 publications

(20 citation statements)

References 70 publications

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“…Antibiotics are not stable in the soil environment. Arseneault and Filion (2017) report on half-life of antibiotics produced by biocontrol strains in soil ranging between 0.25 and 5 days depending on biocontrol strain, antibiotic and experimental conditions. Such short life spans can be due to microbial decomposition but also to chemical and physical inactivation.…”

Section: Direct Interaction With Pathogensmentioning

confidence: 99%

“…In other words: such compounds are characterized as being antibiotic because of their effect on microorganisms at high concentration under in vitro conditions although their function in the natural habitat is very different at the prevailing lower concentrations. Arseneault and Filion (2017) discuss modulation of gene expression by low antibiotic concentrations instead of inciting of cell death at high concentrations. Antibiotics at low concentrations can be involved in signaling and microbial community interactions, communication with plants, and regulation of biofilm formation.…”

Section: Direct Interaction With Pathogensmentioning

confidence: 99%

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Mode of Action of Microbial Biological Control Agents Against Plant Diseases: Relevance Beyond Efficacy

Kolnaar²,

2019

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Microbial biological control agents (MBCAs) are applied to crops for biological control of plant pathogens where they act via a range of modes of action. Some MBCAs interact with plants by inducing resistance or priming plants without any direct interaction with the targeted pathogen. Other MBCAs act via nutrient competition or other mechanisms modulating the growth conditions for the pathogen. Antagonists acting through hyperparasitism and antibiosis are directly interfering with the pathogen. Such interactions are highly regulated cascades of metabolic events, often combining different modes of action. Compounds involved such as signaling compounds, enzymes and other interfering metabolites are produced in situ at low concentrations during interaction. The potential of microorganisms to produce such a compound in vitro does not necessarily correlate with their in situ antagonism. Understanding the mode of action of MBCAs is essential to achieve optimum disease control. Also understanding the mode of action is important to be able to characterize possible risks for humans or the environment and risks for resistance development against the MBCA. Preferences for certain modes of action for an envisaged application of a MBCA also have impact on the screening methods used to select new microbials. Screening of MBCAs in bioassays on plants or plant tissues has the advantage that MBCAs with multiple modes of action and their combinations potentially can be detected whereas simplified assays on nutrient media strongly bias the selection toward in vitro production of antimicrobial metabolites which may not be responsible for in situ antagonism. Risks assessments for MBCAs are relevant if they contain antimicrobial metabolites at effective concentration in the product. However, in most cases antimicrobial metabolites are produced by antagonists directly on the spot where the targeted organism is harmful. Such ubiquitous metabolites involved in natural, complex, highly regulated interactions between microbial cells and/or plants are not relevant for risk assessments. Currently, risks of microbial metabolites involved in antagonistic modes of action are often assessed similar to assessments of single molecule fungicides. The nature of the mode of action of antagonists requires a rethinking of data requirements for the registration of MBCAs.

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Section: Direct Interaction With Pathogensmentioning

confidence: 99%

Section: Direct Interaction With Pathogensmentioning

confidence: 99%

Mode of Action of Microbial Biological Control Agents Against Plant Diseases: Relevance Beyond Efficacy

Kolnaar²,

2019

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“…The concept of hormesis is not new (Stebbing, 1982); however, antimicrobial-induced hormesis has become a new avenue of research (Yim et al, 2007; Mathieu et al, 2016; Okada and Seyedsayamdost, 2017). Different concentrations of antimicrobial compounds may result in various ecologically significant hormetic effects (Stebbing, 1982; Calabrese, 2005; Davies et al, 2006) influencing the expression of genes potentially involved in elevated virulence in pathogenic Bacteria (Davies, 2006; Linares et al, 2006; Mathieu et al, 2016; Arseneault and Filion, 2017; Dersch et al, 2017) increased biofilm formation (Hoffman et al, 2005; Ranieri et al, 2018) and mutation frequency (Gillespie et al, 2005; Henderson-Begg et al, 2006), stimulation bacterial adhesion (Fitzpatrick et al, 2002), and enhanced gene transfer (Wang et al, 2005). Diverse classes of antimicrobials have been analyzed to determine their effects on bacterial physiology.…”

Section: Antimicrobials As a Weapon Or A Toolmentioning

confidence: 99%

Diversity, Ecology, and Prevalence of Antimicrobials in Nature

Mullis

Rambo²,

Baker³

et al. 2019

Front. Microbiol.

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Microorganisms possess a variety of survival mechanisms, including the production of antimicrobials that function to kill and/or inhibit the growth of competing microorganisms. Studies of antimicrobial production have largely been driven by the medical community in response to the rise in antibiotic-resistant microorganisms and have involved isolated pure cultures under artificial laboratory conditions neglecting the important ecological roles of these compounds. The search for new natural products has extended to biofilms, soil, oceans, coral reefs, and shallow coastal sediments; however, the marine deep subsurface biosphere may be an untapped repository for novel antimicrobial discovery. Uniquely, prokaryotic survival in energy-limited extreme environments force microbial populations to either adapt their metabolism to outcompete or produce novel antimicrobials that inhibit competition. For example, subsurface sediments could yield novel antimicrobial genes, while at the same time answering important ecological questions about the microbial community.

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“…To deal with the increasing population of plant pathogens and insect pests on various crops, antagonists (fungi, bacteria, and nematodes spp.) should be exploited to protect humans and the environment from the damages caused by the chemicals (Arseneault and Filion, 2017). Similarly, it is the need of the hour to practice host-specific microbial pathogens to mitigate the weed population.…”

Section: Introductionmentioning

confidence: 99%

A Critical Review of Research on Exploitation of Microbial Antagonists for the Control of Bacterial Diseases in Crop Plants

Malik¹,

Rehman²,

Naqvi³

et al. 2021

Pak. J. Phytopathol.

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Biocontrol through antibiosis: exploring the role played by subinhibitory concentrations of antibiotics in soil and their impact on plant pathogens

Cited by 32 publications

References 70 publications

Mode of Action of Microbial Biological Control Agents Against Plant Diseases: Relevance Beyond Efficacy

Mode of Action of Microbial Biological Control Agents Against Plant Diseases: Relevance Beyond Efficacy

Diversity, Ecology, and Prevalence of Antimicrobials in Nature

A Critical Review of Research on Exploitation of Microbial Antagonists for the Control of Bacterial Diseases in Crop Plants

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