Biocontrol Potentiality of Active Ingredients from Endophytic Bacillus subtilis Isolated from Alhagi pseudalhagi Desv on Maize Spot Diseases

Dawut, Mahmutjan; Abliz, Abdukadir; Ghopur, Wenera; Behti, Pezilet; Obulkhasim, Burabiyem; Mijit, G.

doi:10.4172/2157-7471.1000382

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Possible Target Molecules Of Flavonoids1

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2019

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“…Western blot showed that okanin downregulated levels of nuclear NF-κB p65 and suppressed phosphorylation of IκBα, indicating that it could inhibit LPSinduced activation of the NF-κB signaling pathway. 52)…”

Section: Possible Target Molecules Of Flavonoidsmentioning

confidence: 99%

Natural Inhibitors on Over-Activation of Microglia from Herbals

Bai

Chen

et al. 2019

CHEMICAL & PHARMACEUTICAL BULLETIN

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Neuroinflammation manifested by over-activation of microglial cells plays an essential role in neurodegenerative diseases. Short-term activation of microglia can be beneficial, but chronically activated microglia can aggravate neuronal dysfunction possibly by secreting potentially cytotoxic substances such as tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO), which can result in dysfunction and death of neurons. Therefore inhibiting over-activation of microglia and the production of cytotoxic intermediates may become an effective therapeutic approach for neuroinflammation. In this paper, we review our continuous research on natural inhibitors of over-activated microglia from traditional herbals, including flavonoids, lignans, sesquiterpene coumarins, and stilbenes.

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Section: Possible Target Molecules Of Flavonoidsmentioning

confidence: 99%