Biocontrol Potential of a Lytic Bacteriophage PE204 against Bacterial Wilt of Tomato

Bae, Ju Young; Wu, Jiang; Lee, Hyoung Ju; Jo, Eun Jeong; Senthilkumar, M.; Chung, Eui-Young; Lee, Seon-Woo

doi:10.4014/jmb.1208.08072

Cited by 65 publications

(49 citation statements)

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“…Survival of phage can be improved in the phyllosphere and rhizosphere if they are accompanied by a viable host. This can be an avirulent strain of the pathogen being targeted or indeed another species of bacteria which occurs naturally in that environment (Svircev et al, 2006; Bae et al, 2012; Iriarte et al, 2012). It has also been found that avoiding daylight during application can improve phage-based biocontrol.…”

Section: Phage Application Methods For Optimal Biocontrol Performancementioning

confidence: 99%

Bacteriophages and Bacterial Plant Diseases

et al. 2017

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Losses in crop yields due to disease need to be reduced in order to meet increasing global food demands associated with growth in the human population. There is a well-recognized need to develop new environmentally friendly control strategies to combat bacterial crop disease. Current control measures involving the use of traditional chemicals or antibiotics are losing their efficacy due to the natural development of bacterial resistance to these agents. In addition, there is an increasing awareness that their use is environmentally unfriendly. Bacteriophages, the viruses of bacteria, have received increased research interest in recent years as a realistic environmentally friendly means of controlling bacterial diseases. Their use presents a viable control measure for a number of destructive bacterial crop diseases, with some phage-based products already becoming available on the market. Phage biocontrol possesses advantages over chemical controls in that tailor-made phage cocktails can be adapted to target specific disease-causing bacteria. Unlike chemical control measures, phage mixtures can be easily adapted for bacterial resistance which may develop over time. In this review, we will examine the progress and challenges for phage-based disease biocontrol in food crops.

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Section: Phage Application Methods For Optimal Biocontrol Performancementioning

confidence: 99%

Bacteriophages and Bacterial Plant Diseases

et al. 2017

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“…Thus, bacterial infectious diseases can be treated by the action of phages, a biocontrol method also known as phage therapy. This method can be considered as a promising strategy against bacterial wilt disease (Fujiwara et al, 2011; Bae et al, 2012; Bhunchoth et al, 2015), since it has been successfully applied for controlling some important plant diseases caused by phytopathogenic bacteria (Jones et al, 2007; Balogh et al, 2010; Doffkay et al, 2015; Buttimer et al, 2017). …”

Section: Introductionmentioning

confidence: 99%

Bacteriophage-Based Bacterial Wilt Biocontrol for an Environmentally Sustainable Agriculture

Álvarez

Biosca

2017

Front. Plant Sci.

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Bacterial wilt diseases caused by Ralstonia solanacearum, R. pseudosolanacearum, and R. syzygii subsp. indonesiensis (former R. solanacearum species complex) are among the most important plant diseases worldwide, severely affecting a high number of crops and ornamentals. Difficulties of bacterial wilt control by non-biological methods are related to effectiveness, bacterial resistance and environmental impact. Alternatively, a great many biocontrol strategies have been carried out, with the advantage of being environmentally friendly. Advances in bacterial wilt biocontrol include an increasing interest in bacteriophage-based treatments as a promising re-emerging strategy. Bacteriophages against the bacterial wilt pathogens have been described with either lytic or lysogenic effect but, they were proved to be active against strains belonging to R. pseudosolanacearum and/or R. syzygii subsp. indonesiensis, not to the present R. solanacearum species, and only two of them demonstrated successful biocontrol potential in planta. Despite the publication of three patents on the topic, until now no bacteriophage-based product is commercially available. Therefore, there is still much to be done to incorporate valid bacteriophages in an integrated management program to effectively fight bacterial wilt in the field.

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“…In addition, a number of studies have also focused on applying natural phages to agriculture (28,29), food safety (34,36,37), or veterinary medicine (96,111,112). For example, several natural phage-based products have received regulatory approval for treating food products.…”

Section: Phage Engineering For Pathogen Control Natural Phage-based Amentioning

confidence: 99%

“…The self-replicating nature of phages and the availability of simple, rapid, and low-cost phage production processes are additional advantages for their use as antimicrobials (22). Phages have been used not only to treat and prevent human bacterial infections (9,(23)(24)(25) but also to control plant diseases (26)(27)(28)(29), detect pathogens (30)(31)(32)(33), and assess food safety (34)(35)(36)(37).…”

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confidence: 99%

Genetically Engineered Phages: a Review of Advances over the Last Decade

Pires

Cleto

Sillankorva

et al. 2016

Microbiol Mol Biol Rev

315

275

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SUMMARYSoon after their discovery in the early 20th century, bacteriophages were recognized to have great potential as antimicrobial agents, a potential that has yet to be fully realized. The nascent field of phage therapy was adversely affected by inadequately controlled trials and the discovery of antibiotics. Although the study of phages as anti-infective agents slowed, phages played an important role in the development of molecular biology. In recent years, the increase in multidrug-resistant bacteria has renewed interest in the use of phages as antimicrobial agents. With the wide array of possibilities offered by genetic engineering, these bacterial viruses are being modified to precisely control and detect bacteria and to serve as new sources of antibacterials. In applications that go beyond their antimicrobial activity, phages are also being developed as vehicles for drug delivery and vaccines, as well as for the assembly of new materials. This review highlights advances in techniques used to engineer phages for all of these purposes and discusses existing challenges and opportunities for future work.

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Biocontrol Potential of a Lytic Bacteriophage PE204 against Bacterial Wilt of Tomato

Cited by 65 publications

References 0 publications

Bacteriophages and Bacterial Plant Diseases

Bacteriophages and Bacterial Plant Diseases

Bacteriophage-Based Bacterial Wilt Biocontrol for an Environmentally Sustainable Agriculture

Genetically Engineered Phages: a Review of Advances over the Last Decade

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