Biocontrol of biofilm forming Burkholderia cepacia using a quorum quenching crude lactonase enzyme extract from a marine Chromohalobacter sp. strain D23

Ghosh, Dhritishree; Seth, Madhupa; Mondal, Priyajit; Mukhopadhyay, Subhra Kanti

doi:10.1007/s00203-023-03712-8

Cited by 1 publication

(2 citation statements)

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“…Among them, Chromohalobacter sp. D23 degraded C6 and C8-homoserine lactones and reduced biofilm formation in terms of total biomass and viability in B. cepacia cells [47]. When combined with chloramphenicol, the crude lactonase enzyme of Chromohalobacter sp.…”

Section: Natural Compounds 221 Quorum Sensing Inhibitorsmentioning

confidence: 99%

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New Antimicrobial Strategies to Treat Multi-Drug Resistant Infections Caused by Gram-Negatives in Cystic Fibrosis

Scoffone,

Barbieri,

Irudal

et al. 2024

Antibiotics

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People with cystic fibrosis (CF) suffer from recurrent bacterial infections which induce inflammation, lung tissue damage and failure of the respiratory system. Prolonged exposure to combinatorial antibiotic therapies triggers the appearance of multi-drug resistant (MDR) bacteria. The development of alternative antimicrobial strategies may provide a way to mitigate antimicrobial resistance. Here we discuss different alternative approaches to the use of classic antibiotics: anti-virulence and anti-biofilm compounds which exert a low selective pressure; phage therapies that represent an alternative strategy with a high therapeutic potential; new methods helping antibiotics activity such as adjuvants; and antimicrobial peptides and nanoparticle formulations. Their mechanisms and in vitro and in vivo efficacy are described, in order to figure out a complete landscape of new alternative approaches to fight MDR Gram-negative CF pathogens.

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Section: Natural Compounds 221 Quorum Sensing Inhibitorsmentioning

confidence: 99%

“…In general, Chromohalobacter sp. D23 reduced the QS-mediated synthesis of virulence factors (extracellular polymeric substances, extracellular proteases and hemolysins) [47].…”

Section: Natural Compounds 221 Quorum Sensing Inhibitorsmentioning

confidence: 99%