Bioconjugates Based on Semiconductor Quantum Dots and Porphyrin Ligands: Properties, Exciton Relaxation Pathways and Singlet Oxygen Generation Efficiency for Photodynamic Therapy Applications

Deactivation of Excited States in Nanostructures Containing Cu-Porphyrin Subunit

“…In this case, like for multiporphyrin complexes (described above), a controllable formation of "QD-Porphyrin" nanoassemblies have been realized as a surface passivation of CdSe/ZnS ODs by tetrameso-pyridyl substituted porphyrins (free base and/or Cu-complex) in titration experiments. [29,[90][91][92][93][94][95][96][97][98][99] It is well-known from chemical background that the 3d transition metal Zn 2+ ion (of ZnS shell) has empty 3d 10 orbital while heteroatom N-pyr of the porphyrin mesopyridyl ring is a very good e-donor having an unshared electron pair. Thus, in this case a "key-lock" principle is realized via oneor two-fold non-covalent coordination Zn….N-pyr.…”

“…[29,[90][91][92][93][94][95][96][97][98][99]123] Structures of QDs and porphyrin molecules as well as necessary details explaining the formation of nanoassemblies "QD-Porphyrin" are shown in Figure 9. The results described below concern to the analysis of the interaction between semiconductor CdSe/ZnS quantum dots and surface attached porphyrin molecules (free base and Cu-complex) in order to evaluate the influence of tetrapyrrolic macrocycle on pathways and mechanisms of exciton relaxation in "QD -Cu-porphyrin" nanoassemblies.…”

Водорастворимые конъюгаты ZnS : Mn квантовых точек и хлорина e6 для фотодинамической терапии-=SUP=-*-=/SUP=-

“…Последнее десятилетие активно ведутся работы, по-священные созданию и исследованию гибридных нано-структур на основе КТ и тетрапиррольных молекул для ФДТ онкологических заболеваний [6][7][8][9][10][11]. В подав-ляющем большинстве работ гибридные наноструктуры были сформированы в результате электростатическо-го взаимодействия между функциональными группами тетрапиррольных соединений и молекул-стабилизаторов поверхности КТ.…”

Structural Dynamics and Relaxation Processes with Participation of Excited Singlet and Triplet States in Sterically Hindered Porphyrins and Their Chemical Dimers

“…Firstly, it opens the possibilities to model primary light-induced processes of natural photosynthesis [1][2][3][4][5] and, secondly, is a basis for the development of functional devices in molecular electronics, nanotechnologies, sensorics and biomedicine. [6][7][8][9][10][11][12] In this respect, two principal peculiarities characteristic for tetrapyrrole macrocycles should be mentioned. Tetrapyrroles (mostly heme and chlorophyll derivatives) are ubiquitous cofactors in nature and function in a wide range of biological processes including respiration, electron transfer, oxidation catalysis, signaling to photosynthesis, etc.…”

“…The main spectral-luminescent experiments and emission (fluorescence and phosphorescence) decay measurements were performed on analytical instruments and high-sensitive automated laboratory setups including that for the detection of IRemission of singlet oxygen, which were described in detail in our earlier papers, [6,38,64,65,[78][79][80][81][82][83]87] where standards, necessary equations and expressions as well as experimental errors have been also presented.…”