Bioconcentration of lipophilic organochlorines in ovine dentine

Jan, J; Vrecl, Milka; Pogačnik, A.; Gaspersic, D

doi:10.1016/s0003-9969(01)00079-6

Cited by 6 publications

(16 citation statements)

References 32 publications

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“…From the detailed search, we found 14 articles that measured organic chemicals in tooth bio-matrix. In Table 1, we summarize these studies, providing key details of exposure source, detection rate, and concentrations of the organic chemicals detected in teeth (Camann et al, 2013; Cattaneo et al, 2003; Fos P, 2011; Garcia-Algar et al, 2003; Jan et al, 2006; Jan et al, 2013; Jan and Vrbic, 2000; Jan et al, 2001; Kanjanawattana et al, 2001; Marchei et al, 2008; Pascual et al, 2003; Pellegrini et al, 2006; Schussl et al, 2014; Zeren et al, 2013). These studies ranged from (i) intentional drug abuse (Cattaneo et al, 2003; Pellegrini et al., 2006), (ii) environmental exposures (Garcia-Algar et al, 2003; Pascual et al., 2003), (iii) clinical administration (Fos P, 2011; Schussl et al., 2014) and (iv) personal habits of alcohol consumption (Zeren et al, 2013).…”

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

“…These studies ranged from (i) intentional drug abuse (Cattaneo et al, 2003; Pellegrini et al., 2006), (ii) environmental exposures (Garcia-Algar et al, 2003; Pascual et al., 2003), (iii) clinical administration (Fos P, 2011; Schussl et al., 2014) and (iv) personal habits of alcohol consumption (Zeren et al, 2013). These studies have used teeth from human children (Camann et al, 2013; Garcia-Algar et al, 2003; Jan and Vrbic, 2000; Marchei et al, 2008; Pascual et al, 2003), adults (Fos P, 2011; Schussl et al, 2014; Zeren et al, 2013) and deceased people (Cattaneo et al, 2003), as well as from animals (Jan et al, 2006; Jan et al, 2013; Jan et al., 2001; Kanjanawattana et al, 2001) (Table 1). The tooth bio-matrix has been successfully analyzed for the presence of numerous organics classes e.g.…”

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

“…The tooth bio-matrix has been successfully analyzed for the presence of numerous organics classes e.g. organochlorines (Jan et al, 2006; Jan et al, 2013; Jan and Vrbic, 2000; Jan et al, 2001), anesthetics (Kanjanawattana et al, 2001), illegal drugs (Kanjanawattana et al, 2001; Pellegrini et al, 2006), tobacco (Marchei et al, 2008; Pascual et al, 2003; Pichini et al, 1997), analgesics, pesticides and plastics additives (Camann et al, 2013), alcohol (Zeren et al, 2013), and antibiotics (Fos P, 2011; Schussl et al., 2014) (Table 1). Reported methodologies for extraction and analysis of organic chemicals in teeth are complex.…”

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

“…For deciduous/baby teeth, collection typically occurred upon natural shedding (Camann et al, 2013; Garcia-Algar et al, 2003; Marchei et al, 2008; Pascual et al, 2003), while in other studies teeth were extracted because of dental disease (Jan and Vrbic, 2000; Pellegrini et al, 2006; Schussl et al, 2014) or for the purpose of the study in animals (Fos P, 2011; Jan et al, 2006; Jan et al, 2013; Jan et al, 2001; Kanjanawattana et al, 2001; Zeren et al, 2013), and in certain cases after death (Cattaneo et al, 2003) (Table 2). Benefits of collecting naturally shed teeth include non-invasive bio-matrix collection and these teeth cover the prenatal period whereas only the first molar in permanent teeth start forming before or near birth.…”

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

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Tooth matrix analysis for biomonitoring of organic chemical exposure: Current status, challenges, and opportunities

Andra

Austin

Arora

2015

Environmental Research

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Epidemiological evidence supports associations between prenatal exposure to environmental organic chemicals and childhood health impairments. Unlike the common choice of biological matrices such as urine and blood that can be limited by short half-lives for some chemicals, teeth provide a stable repository for chemicals with half-life in the order of decades. Given the potential of the tooth bio-matrix to study long-term exposures to environmental organic chemicals in human biomonitoring programs, it is important to be aware of possible pitfalls and potential opportunities to improve on the current analytical method for tooth organics analysis. We critically review previous results of studies of this topic. The major drawbacks and challenges in currently practiced concepts and analytical methods in utilizing tooth bio-matrix are (i) no consideration of external (from outer surface) or internal contamination (from micro odontoblast processes), (ii) the misleading assumption that whole ground teeth represent prenatal exposures (latest formed dentine is lipid rich and therefore would absorb and accumulate more organic chemicals), (iii) reverse causality in exposure assessment due to whole ground teeth, and (iv) teeth are a precious bio-matrix and grinding them raises ethical concerns about appropriate use of a very limited resource in exposure biology and epidemiology studies. These can be overcome by addressing the important limitations and possible improvements with the analytical approach associated at each of the following steps (i) tooth sample preparation to retain exposure timing, (ii) organics extraction and pre-concentration to detect ultra-trace levels of analytes, (iii) chromatography separation, (iv) mass spectrometric detection to detect multi-class organics simultaneously, and (v) method validation, especially to exclude chance findings. To highlight the proposed improvements we present findings from a pilot study that utilizes tooth matrix biomarkers to obtain trimester-specific exposure information for a range of organic chemicals.

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Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

See 2 more Smart Citations

Tooth matrix analysis for biomonitoring of organic chemical exposure: Current status, challenges, and opportunities

Andra

Austin

Arora

2015

Environmental Research

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“…Teeth analysis was explored for the presence and quantification of various organic chemicals, contaminants and metabolites such as analgesics, pesticides and plastics additives [36], anesthetics [37], antibiotics [38, 39], illegal drugs [37, 40], metabolites of alcohol [41] and tobacco [42–44], and organochlorines [45–48]. The major limitation of the methodologies employed in these studies was to grind and analyze whole teeth (that constitutes the tissue and blood vessels within the pulp chamber) leading to exposure misclassification because of differential deposition of organic chemicals and contaminants in different tooth compartments.…”

Section: Components Of the Exposome That Are Measurable In Tooth Matrmentioning

confidence: 99%

The tooth exposome in children's health research

Andra

Austin

Arora

2016

Current Opinion in Pediatrics

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Purpose of review The exposome concept proposes a comprehensive assessment of environmental exposures from the prenatal period onwards. However, determining exposure timing especially over the prenatal period is a major challenge in environmental epidemiologic studies. Recent findings For decades teeth have been used to estimate long-term cumulative exposure to metals. Recently developed high-dimensional analytical methods that combine sophisticated histological and chemical analysis to precisely sample tooth layers that correspond to specific life stages have the potential to reconstruct the exposome in the second and third trimesters of prenatal development and during early childhood. Summary A retrospective temporal exposomic approach that precisely measures exposure intensity and timing during prenatal and early childhood development would substantially aid epidemiologic investigations, particularly case–control studies of rare health outcomes.

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How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?

et al. 2021

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The first 1000 days of life, from conception to 2 years, are a critical window for the influence of environmental exposures on the assembly of the oral microbiome, which is the precursor to dental caries (decay), one of the most prevalent microbially induced disorders worldwide. While it is known that the human microbiome is susceptible to environmental exposures, there is limited understanding of the impact of prenatal and early childhood exposures on the oral microbiome trajectory and oral health. A barrier has been the lack of technology to directly measure the foetal "exposome", which includes nutritional and toxic exposures crossing the placenta. Another barrier has been the lack of statistical methods to account for the high dimensional data generated by-omic assays. Through identifying which early life exposures influence the oral microbiome and modify oral health, these findings can be translated into interventions to reduce dental decay prevalence.

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Bioconcentration of lipophilic organochlorines in ovine dentine

Cited by 6 publications

References 32 publications

Tooth matrix analysis for biomonitoring of organic chemical exposure: Current status, challenges, and opportunities

Tooth matrix analysis for biomonitoring of organic chemical exposure: Current status, challenges, and opportunities

The tooth exposome in children's health research

How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?

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