Biocompatible Supramolecular Systems Based on Chlorin e6: Preparation, Photophysical Properties

Abstract

The synthesis methods as well as the data of spectral-fluorescent properties of novel supramolecular systems based on chlorin e 6 (Ce 6) are presented. The effect of various biocompatible excipients such as hydrolyzed polyvinyl alcohol (PVA), poly-N-vinylpyrrolidone (PVP), sodium salt of carboxymethyl cellulose (Na-KMC), dimethylsulfoxide (DMSO), Cremophor® PEG-40 (PEG) on the optical absorption and fluorescence of chlorin e 6 is demonstrated. A red shift of the chlorin e 6 absorption spectrum when using all presented here excipients is a good prerequisite for increasing tissue permeability for visible light. The fluorescence quantum yield j k of chlorin e 6 in systems with all excipients has been calculated. It has been proven, that in all obtained biocompatible systems, except DMSO-Ce 6 system, Ce 6 molecules disaggregate and charge transfer complexes "excipient-Ce 6 " are formed. The high efficiency of such systems as PEG-Ce 6 , PVP-Ce 6 and Na-KMC-Ce 6 for fluorescent diagnosis and photodynamic therapy is noted. The conclusions made in the work can be useful during the new photosensitizer controlled aggregation method development.