Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier

Protat, Marine; Bodin, Noémie; Gobeaux, Frédéric; Malloggi, Florent; Daillant, Jean; Pantoustier, Nadège; Guénoun, P.; Perrin, Patrick

doi:10.1021/acs.langmuir.6b02590

Cited by 31 publications

(19 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evidently, the inherent amphiphilic nature and high interfacial activity of these PZs facilitates the formation of complex emulsions by simple vortex mixing, as opposed to multistep and/or microfluidic techniques. [28][29][30] In addition to using a single polymeric surfactant to stabilize these types of droplets, our system employs homopolymers, rather than block or other architectural variations, thus offering a simplified synthetic approach. [28,[31][32][33][34] The oil droplets containing smaller water droplets ranged primarily from ≈10 to ≈50 μm diameter, while smaller droplets were also observed.…”

Section: Using Ammonium Sulfonate Pzs In Complex Emulsion Formationmentioning

confidence: 99%

Zwitterionic Ammonium Sulfonate Polymers: Synthesis and Properties in Fluids

Brown

Seong

Margossian

et al. 2022

Macromol. Rapid Commun.

View full text Add to dashboard Cite

This article is dedicated to Rudolf Zentel in honor of his significant contributions to the fields of polymer chemistry, nanoscience, and polymeric biomaterials, as well as his promotion of international scientific collaboration and student exchange.Polymer zwitterions continue to emerge as useful materials for numerous applications, ranging from hydrophilic and antifouling coatings to electronic materials interfaces. While several polymer zwitterion compositions are now well established, interest in this field of soft materials science has grown rapidly in recent years due to the introduction of new structures that diversify their chemistry and architecture. Nonetheless, at present, the variation of the chemical composition of the anionic and cationic components of zwitterionic structures remains relatively limited to a few primary examples. In this article, the versatility of 4-vinylbenzyl sultone as a precursor to ammonium sulfonate zwitterionic monomers, which are then used in controlled free radical polymerization chemistry to afford "inverted sulfobetaine" polymer zwitterions, is highlighted. An evaluation of the solubility, interfacial activity, and solution configuration of the resultant polymers reveals the dependence of properties on the selection of tertiary amines used for nucleophilic ring-opening of the sultone precursor, as well as useful properties comparisons across different zwitterionic compositions.

show abstract

Section: Using Ammonium Sulfonate Pzs In Complex Emulsion Formationmentioning

confidence: 99%

Zwitterionic Ammonium Sulfonate Polymers: Synthesis and Properties in Fluids

Brown

Seong

Margossian

et al. 2022

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

“…Moreover, Wang et al reported the morphologies transition induced by varying the amphiphilicity of BCP based on supramolecules or pH-sensitive BCP, and multiple 3D macroporous architectures were generated. Guenoun and co-workers demonstrated that emulsions can be stabilized with a single BCP surfactant which was pH- and temperature-responsive. , By varying the pH value and temperature, type of the emulsion was changed from oil-in-water to water-in-oil. More importantly, multiple emulsions could be obtained in this inversion process.…”

Section: Introductionmentioning

confidence: 99%

“…Guenoun and co-workers demonstrated that emulsions can be stabilized with a single BCP surfactant which was pH-and temperature-responsive. 42,43 By varying the pH value and temperature, type of the emulsion was changed from oil-in-water to water-in-oil. More importantly, multiple emulsions could be obtained in this inversion process.…”

Section: Introductionmentioning

confidence: 99%

Emulsion Solvent Evaporation-Induced Self-Assembly of Block Copolymers Containing pH-Sensitive Block

Wu¹,

Wang²,

Tan³

et al. 2017

Langmuir

View full text Add to dashboard Cite

A simple yet efficient method is developed to manipulate the self-assembly of pH-sensitive block copolymers (BCPs) confined in emulsion droplets. Addition of acid induces significant variation in morphological transition (e.g., structure and surface composition changes) of the polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) assemblies, due to the hydrophobic-hydrophilic transition of the pH-sensitive P4VP block via protonation. In the case of pH > pKa (pKa = 4.8), the BCPs can self-assemble into pupa-like particles because of the nearly neutral wetting of PS and P4VP blocks at the oil/water interface. As expected, onion-like particles obtained when pH is slightly lower than pKa (e.g., pH = 3.00), due to the interfacial affinity to the weakly hydrophilic P4VP block. Interestingly, when pH was further decreased to ∼2.5, interfacial instability of the emulsion droplets was observed, and each emulsion droplet generated nanoscale assemblies including vesicles, worm-like and/or spherical micelles rather than a nanostructured microparticle. Furthermore, homopolymer with different molecular weights and addition ratio are employed to adjust the interactions among copolymer blocks. By this means, particles with hierarchical structures can be obtained. Moreover, owing to the kinetically controlled processing, we found that temperature and stirring speed, which can significantly affect the kinetics of the evaporation of organic solvent and the formation of particles, played a key role in the morphology of the assemblies. We believe that manipulation of the property for the aqueous phase is a promising strategy to rationally design and fabricate polymeric assemblies with desirable shapes and internal structures.

show abstract

“…[18] Via multivalent anchoring on the oil/water interphase, these amphiphilic polymers allowed for the long-term stability of the multiple emulsions. [21] Under high pH and ion concentration, the hydrophobicity of the copolymer was increased, and thus triggered phase inversion to form W/O/W double emulsions. [20] In this case, diblock-copolymer-stabilized emulsions were fabricated via single step.…”

Section: Phase Inversion For Multiple Emulsionsmentioning

confidence: 99%

The Horizon of the Emulsion Particulate Strategy: Engineering Hollow Particles for Biomedical Applications

Xia

et al. 2018

Advanced Materials

View full text Add to dashboard Cite

With their hierarchical structures and the substantial surface areas, hollow particles have gained immense research interest in biomedical applications. For scalable fabrications, emulsion-based approaches have emerged as facile and versatile strategies. Here, the recent achievements in this field are unfolded via an "emulsion particulate strategy," which addresses the inherent relationship between the process control and the bioactive structures. As such, the interior architectures are manipulated by harnessing the intermediate state during the emulsion revolution (intrinsic strategy), whereas the external structures are dictated by tailoring the building blocks and solidification procedures of the Pickering emulsion (extrinsic strategy). Through integration of the intrinsic and extrinsic emulsion particulate strategy, multifunctional hollow particles demonstrate marked momentum for label-free multiplex detections, stimuli-responsive therapies, and stem cell therapies.

show abstract

Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier

Cited by 31 publications

References 36 publications

Zwitterionic Ammonium Sulfonate Polymers: Synthesis and Properties in Fluids

Zwitterionic Ammonium Sulfonate Polymers: Synthesis and Properties in Fluids

Emulsion Solvent Evaporation-Induced Self-Assembly of Block Copolymers Containing pH-Sensitive Block

The Horizon of the Emulsion Particulate Strategy: Engineering Hollow Particles for Biomedical Applications

Contact Info

Product

Resources

About