Biocompatible silver nanoparticles incorporated in acrylic resin for dental application inhibit Candida albicans biofilm

Takamiya, Aline Satie; Monteiro, Douglas Roberto; Gorup, Luiz Fernando; Silva, Ebele Adaobi; Camargo, Emerson Rodriques de; Gomes‐Filho, João Eduardo; Oliveira, Sandra Helena Penha de; Barbosa, Débora Barros

doi:10.1016/j.msec.2020.111341

Cited by 39 publications

(21 citation statements)

References 19 publications

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“…For the same doses, PVP-EG-coated AgNPs resulted in important pro-oxidant effects, as indicated by the induction of protein oxidation and decrease of glutathione levels [ 85 ]. After subcutaneous implantation in rats, colloidal nanosilver determined important subacute inflammatory response of connective tissue but demonstrated long-term biocompatibility, as evidenced after 60 days of exposure [ 86 ].…”

Section: Toxicity Of Silver Nanoparticlesmentioning

confidence: 99%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

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Section: Toxicity Of Silver Nanoparticlesmentioning

confidence: 99%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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“…This is due to its high capability of adherence to oral tissues and denture surfaces, resulting in biofilm formation [14,24]. C. albicans is also the most virulent pathogenic Candida species, accounting for 70-80% of isolates from oral mucosal lesions [25].…”

Section: Causative Pathogens and Risk Factorsmentioning

confidence: 99%

Biomaterials for the Prevention of Oral Candidiasis Development

et al. 2021

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Thousands of microorganisms coexist within the human microbiota. However, certain conditions can predispose the organism to the overgrowth of specific pathogens that further lead to opportunistic infections. One of the most common such imbalances in the normal oral flora is the excessive growth of Candida spp, which produces oral candidiasis. In immunocompromised individuals, this fungal infection can reach the systemic level and become life-threatening. Hence, prompt and efficient treatment must be administered. Traditional antifungal agents, such as polyenes, azoles, and echinocandins, may often result in severe adverse effects, regardless of the administration form. Therefore, novel treatments have to be developed and implemented in clinical practice. In this regard, the present paper focuses on the newest therapeutic options against oral Candida infections, reviewing compounds and biomaterials with inherent antifungal properties, improved materials for dental prostheses and denture adhesives, drug delivery systems, and combined approaches towards developing the optimum treatment.

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“…Примечательно, что концентрация наночастиц 5 % не показала антимикотических результатов, что связано с изменениями в строении материала. Изучение биосовместимости показало подострое местное воспаление в течение первой недели, которое на 60 день наблюдения не отличалось от контроля [33]. Данное исследование показывает перспективы применения AgNP для изготовления зубных протезов с антимикробными свойствами без изменения их физических свойств.…”

Section: материалы студенческой научной школыunclassified

Biomedical Applications of Silver Nanoparticles (Review)

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et al. 2021

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. Silver nanoparticles have unique physicochemical properties and can be used for the diagnosis and treatment of various kinds of infections, oncological diseases, as well as drug delivery. The review presents an analysis of scientific literature on the use of silver nanoparticles for biomedical purposes.Text. The review discusses the perspectives of the silver nanoparticles use in the treatment of oncological diseases as a carrier of drugs, as well as the direct manifestation of their cytotoxic effect on cancer cells. Also, there is considered the use of silver nanoparticles for imparting or enhancing the antibacterial effects of dressings and dental materials. The mechanism of action of silver nanoparticles against viruses is considered. This research presents the use of composite materials containing silver nanoparticles for biomedical purposes.Conclusion. On the basis of the literature data analysis, carried out by the authors, there are shown possibilities of the nanotechnology achievements for the application in medicine.

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Biocompatible silver nanoparticles incorporated in acrylic resin for dental application inhibit Candida albicans biofilm

Cited by 39 publications

References 19 publications

An Updated Review on Silver Nanoparticles in Biomedicine

An Updated Review on Silver Nanoparticles in Biomedicine

Biomaterials for the Prevention of Oral Candidiasis Development

Biomedical Applications of Silver Nanoparticles (Review)

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