Biocompatible Silver-containing a-C:H and a-C coatings: A Comparative Study

Endrino, José L.; Allen, Matthew J.; Galindo, R. Escobar; Zhang, Hanshen; Anders, André; Albella, J. M.

doi:10.1557/proc-0950-d08-02

Cited by 5 publications

(5 citation statements)

References 4 publications

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“…Overall, it can be observed that the percentage of attached cells for all surface treatments is near one hundred percent that of the untreated hydrogen-free DLC film, which is an indicator of a high biocompatibility. In a very recent study, we have reported that the cell viability of nonhydrogenated DLC is significantly superior to that of hydrogenated DLCs [24]. In this study, our analyses show that after 3 tests there were no statistically significant differences in the number of viable cells between sample D (DBD plasma treatment with He + air) and the sample B (treated with high N 2 flow).…”

Section: Cell Viabilitysupporting

confidence: 40%

Functionalization of hydrogen-free diamond-like carbon films using open-air dielectric barrier discharge atmospheric plasma treatments

Endrino

Marco

Allen

et al. 2008

Applied Surface Science

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A dielectric barrier discharge (DBD) technique has been employed to produce uniform atmospheric plasmas of He and N 2 gas mixtures in open air in order to functionalize the surface of filtered-arc deposited hydrogen-free diamond-like carbon (DLC) films. XPS measurements were carried out on both untreated and He/N 2 DBD plasma treated DLC surfaces. Chemical states of the C 1s and N 1s peaks were collected and used to characterize the surface bonds. Contact angle measurements were also used to record the short-and long-term variations in wettability of treated and untreated DLC.In addition, cell viability tests were performed to determine the influence of various He/N 2 atmospheric plasma treatments on the attachment of osteoblast MC3T3 cells.Current evidence shows the feasibility of atmospheric plasmas in producing long-lasting variations in the surface bonding and surface energy of hydrogen-free DLC and consequently the potential for this technique in the functionalization of DLC coated devices. IntroductionIn a recent study it was shown that the nanoscale wettability of a hydrogenterminated diamond surface was lower than that of regions that had been oxidized using an atomic force microscope tip [1]. The difference in wettability between modified diamond surfaces suggests the application of control wettability of modified carbon surfaces in the fields of medicine and biotechnology, which could also be extended to diamond-like carbon films.Diamond-like carbon (DLC) films are known to be hard, low friction and chemically inert materials. Numerous in-vitro and in-vivo experiments have indicated that DLC can have both excellent biocompatibility and hemocompatibility [2][3][4][5]. In the past, the wettability of DLC coatings has been modified by selective doping using both metal and non-metal dopants [6][7][8]. For instance, both silicon and fluorine can be used to increase the surface energy and reduce the contact angle with water. In one study [6], researchers modified the surface energy of DLC by incorporating oxygen and silicon into the bonding network, thus avoiding the use of harmful fluorine-containing hydrocarbon gases. However, the silicon-containing DLC coatings had 20 times lower wear resistance than undoped DLC films. In other recent study [9], phosphorus-doped DLC films were deposited by applying hybrid plasma immersion ion implantation and deposition (PIIID) techniques; the good wettability exhibited by P-doped DLC samples leads to an increase in hemocompatibility. However, in this study the mechanical properties of the modified films were not analyzed. In a different study [5], substrates with various substrate roughness were employed to investigate the attachment of human osteoblast cells to amorphous carbon films with different surface textures. This study concluded that cell attachment increased monotonically with surface roughness. However, smooth surfaces are critical in the vast majority of biomedical applications and topological functionalization of the surface cannot be seen as a wide-rang...

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Section: Cell Viabilitysupporting

confidence: 40%

Functionalization of hydrogen-free diamond-like carbon films using open-air dielectric barrier discharge atmospheric plasma treatments

Endrino

Marco

Allen

et al. 2008

Applied Surface Science

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“…Various methods have been reported of preparing Ag-DLC coatings with different silver concentrations specifically for biomedical applications, which include radio frequency (RF) or direct current (DC) reactive magnetron sputtering of the silver target in a hydrocarbon atmosphere, [185][186][187][188][189][190][191][192][193] DC magnetron sputtering of silver and graphite targets, [194][195][196] hybrid RF/magnetron sputtering plasma assisted chemical vapor deposition (RF/MS PACVD), 197,198 dip coating of a PVP polymer film with a colloidal dispersion of stabilized silver nanoparticles transformed to DLC by ion implantation, [199][200][201] polyethylene transformed to DLC by silver implantation, 202,203 thermionic vacuum arc, 204 silver nanoparticle solution combined with a DLC coating obtained by PACVD, 205 cathodic arc deposition, [206][207][208][209][210] andpulsedlaser deposition. [211][212][213][214][215] Most of these works demonstrate good antibacterial efficacy of these coatings against E. coli, S. aureus,a n dS.…”

Section: Bactericidal Carbon-based Coatings Doped With Silvermentioning

confidence: 99%

“…In this regard, excellent noncytotoxic properties have been reported for DLC coatings with silver concentrations of 2.0% 198 and 3.1%. 193 On the contrary, non-cytotoxic coatings have been obtained for silver concentrations of 5.6% 206 and 6%. 196 More detailed studies demonstrate that the adequate concentration of silver, in terms of physical-chemical properties, for providing an efficient protection against microbial colonization and a noncytotoxic behavior, ranges between 2% and 7%, 213 and more accurately 3.6%.…”

Section: Bactericidal Carbon-based Coatings Doped With Silvermentioning

confidence: 99%

Bactericidal surfaces: An emerging 21st-century ultra-precision manufacturing and materials puzzle

Larrañaga-Altuna

Zabala

Llavori

et al. 2021

Applied Physics Reviews

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Progress made by materials scientists in recent years has greatly helped the field of ultra-precision manufacturing. Ranging from healthcare to electronics components, phenomena such as twinning, dislocation nucleation, and high-pressure phase transformation have helped to exploit plasticity across a wide range of metallic and semiconductor materials. One current problem at the forefront of the healthcare sector that can benefit from these advances is that of bacterial infections in implanted prosthetic devices. The treatment of implant infections is often complicated by the growth of bacterial biofilms on implant surfaces, which form a barrier that effectively protects the infecting organisms from host immune defenses and exogenous antibiotics. Further surgery is usually required to disrupt the biofilm, or to remove the implant altogether to permit antibiotics to clear the infection, incurring considerable cost and healthcare burdens. In this review, we focus on elucidating aspects of bactericidal surfaces inspired by the biological world to inform the design of implant surface treatments that will suppress bacterial colonization. Alongside manufacturing and materials related challenges, the review identifies the most promising natural bactericidal surfaces and provides representative models of their structure, highlighting the importance of the critical slope presented by these surfaces. The scalable production of these complex hierarchical structures on freeform metallic implant surfaces has remained a scientific challenge to date and, as identified by this review, is one of the many 21 st -century puzzles to be addressed by the field of applied physics.

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“…For instance, we have recently doped a-C films with 5 at.-% Ag in order to obtain a biocidal effect. [21,22] Similarly, Au is known to be chemically inert but when dispersed as nanoparticles, it has been found to become active and may be used for low temperature carbon monoxide oxidation. [23] In a recent work, we have examined the influence of the incorporation of various metals (Me ¼ Au, Ag, Mo) on the conductivity and the apparent bandgap.…”

Section: Introductionmentioning

confidence: 99%

“…Doping a‐C film with metal nanoparticles can add functionality to carbon films, known to be inert materials. For instance, we have recently doped a‐C films with 5 at.‐% Ag in order to obtain a biocidal effect 21, 22. Similarly, Au is known to be chemically inert but when dispersed as nanoparticles, it has been found to become active and may be used for low temperature carbon monoxide oxidation 23…”

Section: Introductionmentioning

confidence: 99%

Impact of Annealing on the Conductivity of Amorphous Carbon Films Incorporating Copper and Gold Nanoparticles Deposited by Pulsed Dual Cathodic Arc

Endrino

Horwat

Anders

et al. 2009

Plasma Processes & Polymers

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The influence of annealing in argon at 300 °C on the conductivity, phase stability and electronic structure of hydrogen‐free amorphous carbon (a‐C) films containing copper (a‐C:Cu) and gold (a‐C:Au) nanoclusters was investigated. The motivation of this work is twofold: (1) to study the thermal stability of a‐C:Cu and a‐C:Au films and (2) to point out the relevance of X‐ray absorption near edge structure (XANES) technique to study the structural evolution of metal‐doped a‐C nanocomposites. The films were produced at room temperature using a selective‐bias pulsed dual‐cathode arc deposition technique. Compositional analysis was performed with secondary neutral mass spectroscopy whereas grazing incidence X‐ray diffraction (GIXRD) was used to monitor phase transformation and identify the dispersion or agglomeration of the crystallites within the carbon matrix. XANES spectra at the C‐K was used to investigate the effect of annealing in argon on the electronic structure of the a‐C matrix, while Cu K and Au L‐edges were investigated on a‐C:Cu and a‐C:Au samples, respectively, to study the nanocluster evolution. XANES showed that the a‐C host matrix increased its graphitic character and that stress was relieved upon annealing. No relevant changes were observed in the Au arrangements in a‐C:Au films. In the case of the a‐C:Cu samples, the Cu‐K XANES spectra indicated the formation of Cu2O crystals which correlated well with GIXRD spectra and the decrease in conductivity.

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Biocompatible Silver-containing a-C:H and a-C coatings: A Comparative Study

Cited by 5 publications

References 4 publications

Functionalization of hydrogen-free diamond-like carbon films using open-air dielectric barrier discharge atmospheric plasma treatments

Functionalization of hydrogen-free diamond-like carbon films using open-air dielectric barrier discharge atmospheric plasma treatments

Bactericidal surfaces: An emerging 21st-century ultra-precision manufacturing and materials puzzle

Impact of Annealing on the Conductivity of Amorphous Carbon Films Incorporating Copper and Gold Nanoparticles Deposited by Pulsed Dual Cathodic Arc

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