2016
DOI: 10.1007/s10853-016-0121-3
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Biocompatible silk fibroin scaffold prepared by reactive inkjet printing

Abstract: It has recently been shown that regenerated silk fibroin (RSF) aqueous solution can be printed using an inkjet printer. In this communication, we demonstrate an alternative reactive inkjet printing method that provides control over RSF crystallinity through b-sheet concentration. A biocompatible film has successfully been produced through the alternate printing of RSF aqueous solution and methanol using reactive inkjet printing. Control over the formation of the bsheet structure was achieved by printing differ… Show more

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Cited by 22 publications
(17 citation statements)
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“…It is an emerging new interdisciplinary field that needs cooperation of many fields of science and technology, such as biomaterials, biology, physics, chemistry, computers, mechanics, bioinformatics, and medicine ( Figure 2). During the last 16 years, a large variety of 3D bioprinting technologies have been exploited, which has led to the emergence of fully automatic manufacturing of bioartificial organs for wide biomedical applications, such as high-throughput drug screening, controlled cell transplantation, customized organ repair/regeneration/replacement/restoration, pathological mechanism analysis, metabolism model establishment, and living tissue/organ cryopreservation [10][11][12][13][14][15][16][17][18][19][20]. Based on the working principles, these technologies can be classified into four major groups: inkjet-based, extrusion-based, laser-based, and their combinations ( Figure 3).…”
Section: Introductionmentioning
confidence: 99%
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“…It is an emerging new interdisciplinary field that needs cooperation of many fields of science and technology, such as biomaterials, biology, physics, chemistry, computers, mechanics, bioinformatics, and medicine ( Figure 2). During the last 16 years, a large variety of 3D bioprinting technologies have been exploited, which has led to the emergence of fully automatic manufacturing of bioartificial organs for wide biomedical applications, such as high-throughput drug screening, controlled cell transplantation, customized organ repair/regeneration/replacement/restoration, pathological mechanism analysis, metabolism model establishment, and living tissue/organ cryopreservation [10][11][12][13][14][15][16][17][18][19][20]. Based on the working principles, these technologies can be classified into four major groups: inkjet-based, extrusion-based, laser-based, and their combinations ( Figure 3).…”
Section: Introductionmentioning
confidence: 99%
“…Each of the former three groups has advantages and disadvantages in bioartificial organ manufacturing. [10][11][12][13][14][15][16][17][18][19][20]. Images reproduced with permission from [10][11][12][13][14][15][16][17][18][19][20].…”
Section: Introductionmentioning
confidence: 99%
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“…Then, the mixing and the chemical reaction take place on the substrate's surface, forming the desired chemical structure. Silk micro‐rockets, as well as silk fibroin scaffolds, have successfully been created using the full RIJ approach . In both the cases, a silk ink is reacted with a methanol ink in order to transform the soluble random coil silk structure into the insoluble beta‐sheet structure.…”
Section: Introductionmentioning
confidence: 99%