Biocompatible silica-based magnesium composites

Panemangalore, Devadas Bhat; Shabadi, Rajashekhara; Tingaud, David; Touzin, Matthieu; Ji, Gang

doi:10.1016/j.jallcom.2018.09.060

Cited by 17 publications

(8 citation statements)

References 37 publications

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“…The observed peaks are in line with other work on sintered Mg-SiO 2 materials, with Mg 2 Si being present in mechanically alloyed [ 42 ] and/or sintered materials [ 43 ] within the previous works. In addition, the SiO 2 peak observed in Figure 12 b was also in line with nanosized SiO 2 in the literature [ 44 ].…”

Section: Discussionsupporting

confidence: 91%

An Investigation into the Potential of Turning Induced Deformation Technique for Developing Porous Magnesium and Mg-SiO2 Nanocomposite

Johanes

Gupta

2023

Materials

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A new and novel method of synthesising porous Mg materials has been explored utilising a variant of a processing method previously used for the synthesis of dense Mg materials, namely the turning-induced deformation (TID) method combined with sintering. It was found that the Mg materials synthesised possessed comparable properties to previously-synthesised porous Mg materials in the literature while subsequent sintering resulted in a more consistent mechanical response, with microwave sintering showing the most promise. The materials were also found to possess mechanical response within the range of the human cancellous bone, and when reinforced with biocompatible silica nanoparticles, presented the most optimal combination of mechanical properties for potential use as biodegradable implants due to most similarity with cancellous bone properties.

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Section: Discussionsupporting

confidence: 91%

An Investigation into the Potential of Turning Induced Deformation Technique for Developing Porous Magnesium and Mg-SiO2 Nanocomposite

Johanes

Gupta

2023

Materials

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“…It could be found that the degradation rates of the Fe/Mg 2 Si composites (0.15 ± 0.013, 0.21 ± 0.015, 0.31 ± 0.021, and 0.33 ± 0.030 mm/y for Fe/0.3Mg 2 Si, Fe/0.6Mg 2 Si, Fe/0.9Mg 2 Si, and Fe/1.2Mg 2 Si, respectively) were obviously higher than that of Fe (0.12 ± 0.011 mm/y) and the degradation rate increased with the increasing content of Mg 2 Si in the composites. This trend was explained by the decomposition of Mg 2 Si in the SBF through a chemical reaction with H 2 O[ 45 , 46 ]. It should be stated that the degradation rates of Fe/0.9Mg 2 Si and Fe/1.2Mg 2 Si composites were among 0.2 – 0.5 mm/y, which was a suitable degradation rate to match the restoration process of new bone[ 2 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation

Shuai

Peng

et al. 2020

IJB

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Fe is regarded as a promising bone implant material due to inherent degradability and high mechanical strength, but its degradation rate is too slow to match the healing rate of bone. In this work, hydrolytic expansion was cleverly exploited to accelerate Fe degradation. Concretely, hydrolyzable Mg2Si was incorporated into Fe matrix through selective laser melting and readily hydrolyzed in a physiological environment, thereby exposing more surface area of Fe matrix to the solution. Moreover, the gaseous hydrolytic products of Mg2Si acted as an expanding agent and cracked the dense degradation product layers of Fe matrix, which offered rapid access for solution invasion and corrosion propagation toward the interior of Fe matrix. This resulted in the breakdown of protective degradation product layers and even the direct peeling off of Fe matrix. Consequently, the degradation rate for Fe/Mg2Si composites (0.33 mm/y) was significantly improved in comparison with that of Fe (0.12 mm/y). Meanwhile, Fe/Mg2Si composites were found to enable the growth and proliferation of MG-63 cells, showing good cytocompatibility. This study indicated that hydrolytic expansion may be an effective strategy to accelerate the degradation of Fe-based implants.

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“…Despite the fact that PBS has been extensively used as the corrosion testing medium of Mg and its alloys [61][62][63][64], it is not generally a suitable solution to simulate or predict the in vivo degradation behavior of Mg, since phosphate with Mg 2+ can create insoluble precipitation on the surface of the metal, which can produce inaccurate results [53,65]. Mena-Morcillo et al [66] investigated the degradation of AZ31 and AZ91 Mg alloys in SBF, Hanks', and Ringer's solutions.…”

Section: Mg Corrosion In Simulated Body Environmentsmentioning

confidence: 99%

Biodegradable Magnesium Biomaterials—Road to the Clinic

Amukarimi

Mozafari

2022

Bioengineering

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In recent decades, we have witnessed radical changes in the use of permanent biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without releasing toxic degradation products has led to a vast range of applications in the biomedical field, including cardiovascular stents, musculoskeletal, and orthopedic applications. With the use of biodegradable Mg biomaterials, patients would not suffer second surgery and surgical pain anymore. Be that as it may, the main drawbacks of these biomaterials are the high corrosion rate and unexpected degradation in physiological environments. Since biodegradable Mg-based implants are expected to show controllable degradation and match the requirements of specific applications, various techniques, such as designing a magnesium alloy and modifying the surface characteristics, are employed to tailor the degradation rate. In this paper, some fundamentals and particular aspects of magnesium degradation in physiological environments are summarized, and approaches to control the degradation behavior of Mg-based biomaterials are presented.

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Biocompatible silica-based magnesium composites

Cited by 17 publications

References 37 publications

An Investigation into the Potential of Turning Induced Deformation Technique for Developing Porous Magnesium and Mg-SiO2 Nanocomposite

An Investigation into the Potential of Turning Induced Deformation Technique for Developing Porous Magnesium and Mg-SiO2 Nanocomposite

Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation

Biodegradable Magnesium Biomaterials—Road to the Clinic

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