Biocompatible silane adhesion layer on titanium implants improves angiogenesis and osteogenesis

Zhao, Yuyu; Sun, Yonghua; Hang, Ruiyue; Yao, Runhua; Zhang, Yi; Huang, Di; Yao, Xiaohong; Bai, Long; Hang, Ruiqiang

doi:10.1016/j.bioadv.2022.213033

Cited by 11 publications

(6 citation statements)

References 87 publications

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“…The C and O elements on the Ti surface might originate from the adsorption of contaminants in the air. The sharp increase in O content and the appearance of Na element were due to the formation of a nanostructured sodium titanate layer on the titanium substrate surface after alkali treatment [13,15,25]. After ascorbic acid spin-coating, the increase in C content indicated that ascorbic acid was successfully grafted on the surface of the alkali-treated samples.…”

Section: Physicochemical Characterization Of the Sample Surfacesmentioning

confidence: 99%

“…The combination of ascorbic acid and anti-tumor agents not only improves the therapeutic efficacy against the primary tumor, but also overcomes the major limitations of conventional therapy, such as drug resistance, post-surgery recurrence, and tumor metastasis [23]. Ascorbic acid is an important supplement to induce osteogenic differentiation in the culture of multiple osteoblasticlineage cells [10,13,24,25]. Potent stimulation by ascorbic acid elicits collagen synthesis and secretion by osteoblasts, allowing extracellular matrix (ECM) assembly and promoting focal adhesion of osteoblasts [26,27].…”

Section: Introductionmentioning

confidence: 99%

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An ascorbic acid-decorated nanostructured surface on titanium inhibits breast cancer development and promotes osteogenesis

Li,

Liu,

Shi

et al. 2023

Biomed. Mater.

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The chest wall is the most frequent metastatic site of breast cancer (BC) and the metastasis usually occurs in a solitary setting. Chest wall resection is a way to treat solitary BC metastasis, but intraoperative bone defects and local tumor recurrence still affect the life quality of patients. Titanium-based prostheses are widely used for chest wall repair and reconstruction, but their inherent bio-inertness makes their clinical performance unfavorable. Nanostructured surfaces can give titanium substrates the ability to excellently modulate a variety of cellular functions. Ascorbic acid is a potential stimulator of tumor suppression and osteogenic differentiation. An ascorbic acid-decorated nanostructured titanium surface was prepared through alkali treatment and spin-coating technique and its effects on the biological responses of BC cells and osteoblasts were assessed. The results exhibited that the nanorod structure and ascorbic acid synergistically inhibited the proliferation, spreading, and migration of BC cells. Additionally, the ascorbic acid-decorated nanostructured surface significantly promoted the proliferation and osteogenic differentiation of osteoblasts. This work may provide valuable references for the clinical application of titanium materials in chest wall reconstruction after the resection of metastatic BC.

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Section: Physicochemical Characterization Of the Sample Surfacesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An ascorbic acid-decorated nanostructured surface on titanium inhibits breast cancer development and promotes osteogenesis

Li,

Liu,

Shi

et al. 2023

Biomed. Mater.

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“…21,22 For this reason, to covalently bond and immobilize cationic silane on the implant, some methods, such as hydrothermal treatment (HT), have been used to introduce −OH on the Ti surface. 26 Nevertheless, although there is a strong covalent bond between the generated hydroxyl with the cationic silane, the HT treatment is not easy to handle in practice because it requires the control of several parameters, such as solution chemistry, concentration, temperature, pressure, and time. 24 Additionally, considering that one of the major causes of implant failures is still poor implant−bone integration, a surface that could mitigate biofilm formation and be beneficial for enhanced osteoconductive properties is needed.…”

Section: Introductionmentioning

confidence: 99%

“…Immobilizing hydrophobic alkyl chains, such as cationic silane, by immersing hydroxylated Ti in APTES solution may effectively enhance the antimicrobial properties of the biomaterial. , For this reason, to covalently bond and immobilize cationic silane on the implant, some methods, such as hydrothermal treatment (HT), have been used to introduce −OH on the Ti surface . Nevertheless, although there is a strong covalent bond between the generated hydroxyl with the cationic silane, the HT treatment is not easy to handle in practice because it requires the control of several parameters, such as solution chemistry, concentration, temperature, pressure, and time .…”

Section: Introductionmentioning

confidence: 99%

Boosting Titanium Surfaces with Positive Charges: Newly Developed Cationic Coating Combines Anticorrosive and Bactericidal Properties for Implant Application

Silva

Costa

Nagay

et al. 2023

ACS Biomater. Sci. Eng.

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Along with poor implant−bone integration, peri-implant diseases are the major causes of implant failure. Although such diseases are primarily triggered by biofilm accumulation, a complex inflammatory process in response to corrosive-related metallic ions/debris has also been recognized as a risk factor. In this regard, by boosting the titanium (Ti) surface with silane-based positive charges, cationic coatings have gained increasing attention due to their ability to kill pathogens and may be favorable for corrosion resistance. Nevertheless, the development of a cationic coating that combines such properties in addition to having a favorable topography for implant osseointegration is lacking. Because introducing hydroxyl (−OH) groups to Ti is essential to increase chemical bonds with silane, Ti pretreatment is of utmost importance to achieve such polarization. In this study, plasma electrolytic oxidation (PEO) was investigated as a new route to pretreat Ti with OH groups while providing favorable properties for implant application compared with traditional hydrothermal treatment (HT). To produce bactericidal and corrosion-resistant cationic coatings, after pretreatment with PEO or HT (Step 1), surface silanization was subsequently performed via immersion-based functionalization with 3-aminopropyltriethoxysilane (APTES) (Step 2). In the end, five groups were assessed: untreated Ti (Ti), HT, PEO, HT+APTES, and PEO+APTES. PEO created a porous surface with increased roughness and better mechanical and tribological properties compared with HT and Ti. The introduction of −OH groups by HT and PEO was confirmed by Fourier transform infrared spectroscopy and the increase in wettability producing superhydrophilic surfaces. After silanization, the surfaces were polarized to hydrophobic ones, and an increase in the amine functional group was observed by X-ray photoelectron spectroscopy, demonstrating a considerable amount of positive ions. Such protonation may explain the enhanced corrosion resistance and dead bacteria (Streptococcus aureus and Escherichia coli) found for PEO+APTES. All groups presented noncytotoxic properties with similar blood plasma protein adsorption capacity vs the Ti control. Our findings provide new insights into developing next-generation cationic coatings by suggesting that a tailorable porous and oxide coating produced by PEO has promise in designing enhanced cationic surfaces targeting biomedical and dental implant applications.

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“…Nanotechnology is widely used in medicine, such as tissue repair, diagnosis, and treatment of diseases ( Lin et al, 2020a ; Lin et al, 2020b ; Zhang et al, 2020 ; Bai et al, 2021 ; Chen et al, 2021 ; Zhao et al, 2022 ). Professor Feng’s team developed a GSH bioimprinted nanocomposite loaded with an FTO inhibitor (GNPIPP12MA).…”

Section: Introductionmentioning

confidence: 99%

Advanced nanoparticles that can target therapy and reverse drug resistance may be the dawn of leukemia treatment: A bibliometrics study

Wang¹,

Zhao²,

Jiang

et al. 2022

Front. Bioeng. Biotechnol.

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With the development of nanomedicine, more and more nanoparticles are used in the diagnosis and treatment of leukemia. This study aimed to identify author, country, institutional, and journal collaborations and their impacts, assess the knowledge base, identify existing trends, and uncover emerging topics related to leukemia research. 1825 Articles and reviews were obtained from the WoSCC and analyzed by Citespace and Vosviewer. INTERNATIONAL JOURNAL OF NANOMEDICINE is the journal with the highest output. The contribution of FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY is also noteworthy. The three main aspects of research in Nanoparticles-leukemia-related fields included nanoparticles for the diagnosis and treatment of leukemia, related to the type and treatment of leukemia, the specific molecular mechanism, and existing problems of the application of nanoparticles in leukemia. In the future, synthesize nano-drugs that have targeted therapy and chemotherapy resistance according to the mechanism, which may be the dawn of the solution to leukemia. This study offers a comprehensive overview of the Nanoparticles-leukemia-related field using bibliometrics and visual methods for the first time, providing a valuable reference for researchers interested in Nanoparticles-leukemia.

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Biocompatible silane adhesion layer on titanium implants improves angiogenesis and osteogenesis

Cited by 11 publications

References 87 publications

An ascorbic acid-decorated nanostructured surface on titanium inhibits breast cancer development and promotes osteogenesis

An ascorbic acid-decorated nanostructured surface on titanium inhibits breast cancer development and promotes osteogenesis

Boosting Titanium Surfaces with Positive Charges: Newly Developed Cationic Coating Combines Anticorrosive and Bactericidal Properties for Implant Application

Advanced nanoparticles that can target therapy and reverse drug resistance may be the dawn of leukemia treatment: A bibliometrics study

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