Biocompatible Quantum Dots for Biological Applications

Rosenthal, Sandra J.; Chang, Jerry C.; Kovtun, Oleg; McBride, James R.; Tomlinson, Ian

doi:10.1016/j.chembiol.2010.11.013

Cited by 484 publications

(357 citation statements)

References 121 publications

(149 reference statements)

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“…In the recent research on semiconductor, nanoparticles (NPs)/quantum dots (QDs) have become so important because of their greater potential in opto-electronic devices and biological applications (Coe et al 2002;Fonoberov and Balandin 2006;Rosenthal et al 2011;Singh et al 2012). The optical properties of QDs strongly depend on the inter-dot distance which in turn is due to the quantum size effect .…”

Section: Introductionmentioning

confidence: 99%

Structural and optical characterization of pure and starch-capped ZnO quantum dots and their photocatalytic activity

Vidhya¹,

Saravanan

Bhoopathi³

et al. 2014

Appl Nanosci

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Among the different types of metal oxides, zinc oxide (ZnO) is a most commonly used metal oxide in a broad variety of applications. In the present investigation, a modified green synthesis route was used to synthesize pure and starch-capped ZnO (ZnO/starch) quantum dots (QDs) and studied their structural and optical characteristics. In this study, hexagonal crystal structure was observed in both pure and ZnO/starch QDs using X-ray diffraction technique. A spherical-shaped surface morphology was found with the size of 5-10 nm using transmission electron microscope technique. The interaction between ZnO QDs and starch molecules was proved via Fourier infra-red spectrometer technique. On the other hand, their fluorescence behaviors were investigated using photoluminescence technique, in that the ZnO/starch QDs showed an enhanced emission behavior when compared to the pure ZnO QDs. Further, the solar photocatalytic activity of both the ZnO QDs was examined with the dye Rhodamine B (RhB) at the end of 30, 60, 90, and 120 min. In this, ZnO/ starch QDs show a good and more decomposition of RhB than pure ZnO QDs. Collectively, in the present study, green synthesis route produced an efficient QDs (pure and ZnO/starch) and it will be very useful for many other QDs. The ZnO/starch QDs are suitable for decomposing the RhB and other toxic organic dyes.

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Section: Introductionmentioning

confidence: 99%

Structural and optical characterization of pure and starch-capped ZnO quantum dots and their photocatalytic activity

Vidhya¹,

Saravanan

Bhoopathi³

et al. 2014

Appl Nanosci

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“…The existence of the QD and FRET fluorescence without LCN1 was likely attributed to non-specific binding from the adsorption of the QD-conjugated probe antibodies. 42 A bar chart quantifying the observation is shown in Fig. 6(e).…”

Section: Detection Of Lcn1 Based On the Fret Immunosensingmentioning

confidence: 99%

A bead-based fluorescence immunosensing technique enabled by the integration of Förster resonance energy transfer and optoelectrokinetic concentration

Wang

Shieh

et al. 2016

Biomicrofluidics

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Bead-based immunosensing has been growing as a promising technology in the point-of-care diagnostics due to great flexibility. For dilute samples, functionalized particles can be used to collect dispersed analytes and act as carriers for particle manipulation. To realize rapid and visual immunosensing, F€ orster resonance energy transfer (FRET) was used herein to ensure only the diabetic biomarker, lipocalin 1, to be detected. The measurement was made in an aqueous droplet sandwiched between two parallel plate electrodes. With an electric field and a focused laser beam applying on the microchip simultaneously, the immunocomplexes in the droplet were further concentrated to enhance the FRET fluorescent signal. The optoelectrokinetic technique, termed rapid electrokinetic patterning (REP), has been proven to be excellent in dynamic and programmable particle manipulation. Therefore, the detection can be complete within several tens of seconds. The lower detection limit of the REP-enabled bead-based diagnosis reached nearly 5 nM. The combinative use of FRET and the optoelectrokinetic technique for the bead-based immunosensing enables a rapid measure to diagnose early stage diseases and dilute analytes. V C 2016 AIP Publishing LLC. [http://dx

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“…Compared with traditional organic fluorescent probes, QDs possess a wide absorption spectra and a narrow emission peak for simultaneous excitation of multiple fluorescence colors, high fluorescence intensity, long fluorescent duration, stable fluorescence of long-term emission and strong resistance to photobleaching (9). Previous studies have demonstrated that QDs may be used in the labeling of live cells and cancer cells for animal imaging and tracking in vivo (10)(11)(12)(13). QDs have demonstrated prognostic potential in the early diagnosis and targeted therapy of tumors (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Effect of quantum dots on the biological behavior of the EJ human bladder urothelial carcinoma cell line

Yuan

Zhang

et al. 2015

Molecular Medicine Reports

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Abstract. Quantum dots (QDs) are a type of fluorescent label with applications in biological molecules, cells and in vivo imaging. The current study investigated the effect of QDs on the toxicity, proliferation, migration and invasion of the EJ human bladder cancer cell line in vitro. The cell counting kit-8 test was used to measure the survival rate of EJ cells following incubation with varying concentrations of QDs. Additionally, the effect of QDs on tumor cell migration and invasion was evaluated using the Transwell chamber assay, and cell proliferation rate was assessed using a hemocytometer. Data from the current study demonstrated no significant differences in survival rate between the experimental and control groups with the conventionally used concentrations (5, 10 and 20 nM) of QD605 (P>0.05). However, with high concentrations of QD605 (40 and 80 nM), significant differences were observed (P<0.001). The survival rate of EJ cells, however, remained at 92.6%. In addition, no significant differences were observed between the EJ cells labeled with transactivator of transcription (TAT)-QD605 and the unlabeled EJ cells with regard to proliferation, migration and invasion (P>0.05). Thus, the results of the current study indicate that QDs exhibit a certain degree of influence on the activity of the EJ bladder cancer cell line at high concentrations. However, at the concentrations that QDs are conventionally used, there was little impact on the survival of the EJ cells. In addition, the proliferation, migration and invasion abilities of the EJ cells were not affected by TAT-QDs. Therefore, the peptide-conjugated QDs have potential to be applied in the imaging and tracking of live cells in vitro and of animals in vivo. Notably, QDs may provide the foundation for a novel, non-invasive imaging strategy for the early diagnosis of tumors.

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Biocompatible Quantum Dots for Biological Applications

Cited by 484 publications

References 121 publications

Structural and optical characterization of pure and starch-capped ZnO quantum dots and their photocatalytic activity

Structural and optical characterization of pure and starch-capped ZnO quantum dots and their photocatalytic activity

A bead-based fluorescence immunosensing technique enabled by the integration of Förster resonance energy transfer and optoelectrokinetic concentration

Effect of quantum dots on the biological behavior of the EJ human bladder urothelial carcinoma cell line

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