Biocompatible properties of surgical mesh using an animal model

Krause, Hannah; Galloway, Stuart; Khoo, S. K.; Lourie, Rohan; Goh, Judith

doi:10.1111/j.1479-828x.2006.00513.x

Cited by 55 publications

(29 citation statements)

References 17 publications

(14 reference statements)

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“…This might explain the persistence of granulomatous reaction among multifilament meshes in our study, confirming the finding of other authors [4,17].…”

Section: Discussionsupporting

confidence: 82%

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Impact of the structure of polypropylene meshes in local tissue reaction: in vivo stereological study

et al. 2008

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Polypropylene slings are monofilament and multifilament meshes. Their features can impact clinical outcomes. We analyzed tissue reaction, inflammation, and the density of collagen fibers elicited by polypropylene meshes in the subcutaneous tissue of female rats. Thirty female Wistar rats underwent the implantation of 8x4-mm polypropylene meshes (two monofilamentar and two multifilamentar). The rats were killed at 7, 60, and 120 days after implant. Stereology was used to analyze the collagen fiber density. Acute inflammation was more intense in the early post-implant period (p=0.006), except for intravaginal slingplasty (p=0.342). Lymphoplasmocytic reaction was more intense in multifilament samples, even after 60 days (p<0.001) and 120 days (p=0.001). The stereological analysis showed significant differences between mono- and multifilament meshes, considering that monofilament meshes induced more collagen deposition and a greater density of collagen fibers (p<0.001). Multifilament meshes produced a more granulomatous reaction. The collagen fiber density was greater in monofilament meshes, which induced more favorable biocompatibility assessed objectively.

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“…This might explain the persistence of granulomatous reaction among multifilament meshes in our study, confirming the finding of other authors [4,17].…”

Section: Discussionsupporting

confidence: 82%

“…This finding was not corroborated by Krause et al [17], who found more intense fibrosis after multifilament mesh implant.…”

Section: Discussioncontrasting

confidence: 54%

Impact of the structure of polypropylene meshes in local tissue reaction: in vivo stereological study

et al. 2008

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“…The most widely used mesh in pelvic floor repair is a monofilamentous, macroporous PP mesh. Krause et al assessed the in vitro biomechanical properties of raw meshes commonly used in pelvic floor surgery [7]. They examined material properties of eight different types of surgical meshes using tensile tests.…”

Section: Biocompatibilitymentioning

confidence: 99%

“…No residual polyglactin was found 84 days after implantation. However, another study examining the inflammatory response to various type I and III meshes found that PP/Vicryl® composite mesh implantation led to a greater inflammatory response of giant cells and histiocytes than other type I heavyweight meshes after 12 weeks [43].…”

Section: Composite Meshesmentioning

confidence: 99%

Polypropylene mesh and the host response

2012

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“…Increased inflammatory and fibrotic responses may be the consequence of the multifilamentous nature of the meshes since this causes more inflammatory response of giant cells and histiocytes. While adequate fibrosis is anticipated to give good tissue strength, excessive tissue fibrosis may result in reduced tissue flexibility which is a significant issue in genital tract surgery [6,7] .…”

Section: Discussionmentioning

confidence: 99%

Time-Dependent Changes in Biomechanical Properties of Four Different Synthetic Materials in a Rabbit Model and the Importance in Respect to Sling Surgery

et al. 2008

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Aim: To examine the time-dependent biomechanical properties of four different implanted synthetic materials. Materials and Methods: 18 New Zealand rabbits were randomly categorized into three groups: group 1 to be evaluated at the 2nd week, group 2 at the 8th week, and group 3 at the 12th week. Before the implantation, baseline values were obtained. Each of the 2 × 5 cm sized materials of mersilene, prolene, ultrapro and vypro mesh were placed in the anterior abdominal fascia. The mesh materials were removed, tensile strength (N/mm²) and ultimate strain (%) were measured by tensinometry and surface area losses (cm²) were calculated. Results: Tensile strength values (mean ± SD) were 9.2 ± 1.5, 8.5 ± 1.2 for mersilene, 25.2 ± 7.3, 14.0 ± 2.9 for prolene, 2.2 ± 0.6, 12.5 ± 1.4 for ultrapro and 8.1 ± 1.6, 7.0 ± 1.8 for vypro at baseline and the 12th week. Ultimate strain values (mean ± SD) were 131.2 ± 46.1, 110.4 ± 98.6 for mersilene, 181.0 ± 26.4, 78.5 ± 14.4 for prolene, 91.5 ± 8.2, 89.6 ± 20.5 for ultrapro and 84.3 ± 8.9, 55.0 ± 13.2 for vypro at baseline and the 12th week. Surface areas (mean ± SD) were 8.87 ± 0.14, 9.38 ± 0.17, 8.4 ± 0.32 and 8.76 ± 0.16 for mersilene, prolene, ultrapro and vypro at the 12th week respectively. Conclusions: Although prolene mesh demonstrated a decrease in its tensile strength it still remains the highest at the 12th week. Considering the significant time-dependent increase in its tensile strength, ultrapro mesh should be studied in humans. A final decision on the preference of ultrapro mesh in sling surgery could be reached after such studies.

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Biocompatible properties of surgical mesh using an animal model

Cited by 55 publications

References 17 publications

Impact of the structure of polypropylene meshes in local tissue reaction: in vivo stereological study

Impact of the structure of polypropylene meshes in local tissue reaction: in vivo stereological study

Polypropylene mesh and the host response

Time-Dependent Changes in Biomechanical Properties of Four Different Synthetic Materials in a Rabbit Model and the Importance in Respect to Sling Surgery

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