Biocompatible polymer microneedle for topical/dermal delivery of tranexamic acid

Machekposhti, Sina Azizi; Soltani, Majid; Najafizadeh, Parvaneh; Ebrahimi, Soltan Ahmad; Chen, P.

doi:10.1016/j.jconrel.2017.06.016

Cited by 74 publications

(35 citation statements)

References 25 publications

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“…Biocompatible polymer microneedles have been fabricated and characterized . One advantage is that this type of microneedle can be cost‐effectively produced and does not carry a substantial risk of breakage in the skin due to biodegradability.…”

Section: Discussionmentioning

confidence: 99%

Enhanced immunity in intradermal vaccination by novel hollow microneedles

Ogai¹,

Nonaka²,

Toda³

et al. 2018

Skin Research and Technology

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Section: Discussionmentioning

confidence: 99%

Enhanced immunity in intradermal vaccination by novel hollow microneedles

Ogai¹,

Nonaka²,

Toda³

et al. 2018

Skin Research and Technology

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“…In vivo (human) [24] Melasma Dissolving In vivo (mouse) [25] Acne vulgaris Swelling In vivo (mouse) [26] Ocular infection Dissolving Ex vivo (cornea) [27] Diabetes Swelling In vitro In vivo (mouse) [28] [ 29] Cancer Dissolving In vitro In vivo (mouse) [30] [ 31,43] Immunity (vaccines)…”

Section: Warts Coatedmentioning

confidence: 99%

“…Machekposhti et al fabricated a biocompatible polymer microneedle from PVP and methacrylic acid to enable the effective local release of tranexamic acid. [25] Another common inflammatory skin disease is acne vulgaris, which has physiological and psychological influences on patients. Antibiotic cream is commonly used to treat acne, but the transport of the drug is limited by the barrier properties of skin.…”

Section: Therapeutics and Beyondmentioning

confidence: 99%

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

Dardano

Battisti²,

Rea

et al. 2019

Advanced Therapeutics

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Mainly designed and realized as a painless alternative to the hypodermic syringe, microneedle-based devices are currently approaching commercial market placement. The considerable academic and industrial investment in this technology is reflected by a multitude of papers published and patents registered every year, which is also a sign of a field in full fermentation. New materials and innovative methodologies are continuously exploited in search of the best performance at the lowest cost. For these reasons, an updated review, focused predominantly on the last year of scientific production, is a useful guideline in this rapidly changing panorama. This report provides a critical review of microneedle technologies presented in the very recent literature with a particular focus on those closest to the needs of the healthcare field. Although a few devices are already commercial, further effort is still needed to achieve complete clinical translation and therapeutic efficacy competitive with or superior to those of the devices used as standards and adopted by national health systems.

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“…34% of the released drug was locally effective and the rest permeated through the skin. This polymer microneedle had no dermal toxicity [70]. Anastasia et al, (2017) prepared 16 separate microneedle groups (microneedle height 600 mm), with aqueous mixtures of 15% w/w Gantrez1 S97 and 7.5% w/w PEG 10,000 Da.…”

Section: Microneedlesmentioning

confidence: 99%

A Review about various Nanomaterials in Drug Delivery Systems and their Applications

Brahamdutt¹,

Arun²,

Sangwan³

et al. 2018

IJRDPL

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Most of drug entities face the problems like reduced absorption, faster metabolism and elimination, toxicity because of drug distribution to other tissues, low drug solubility, unpredictable bioavailability, etc. These issues need to be work out so as to make the novel drug delivery systems for successful therapy. Use of nanotechnology is one of the promising strategies to overcome all of these problems. Distinctive properties of nanomaterials like smaller particles size, high surface area, and ease of suspending in liquids, deeper access across the cells and organelles, flexib le optical and magnetic properties are offered by nanoparticles as compared to other micro or macro sized particles. Nanomaterials can be classified into different categories based on their drug delivery system, dimensions, structure and consistency. Various types of nano-formulations (such as nanoparticles, nano-suspension, liposomes, hydrogels, solid lipid nanoparticles, dendrimers, microneedles, ocular insert/disk, transcorneal iontophoresis) have been used by the researchers for modulating the physicochemical properties and biological activities of the drugs. This review highlights the various types of nanomaterials with their advantages and applications in the pharmaceuticals for enhanced physicochemical properties and better biological activities with reduced toxicity and higher biocompatibility .

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Biocompatible polymer microneedle for topical/dermal delivery of tranexamic acid

Cited by 74 publications

References 25 publications

Enhanced immunity in intradermal vaccination by novel hollow microneedles

Enhanced immunity in intradermal vaccination by novel hollow microneedles

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

A Review about various Nanomaterials in Drug Delivery Systems and their Applications

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