Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents

Jeong, Sang Young; Kim, Hyo Jeong; Kwak, Byung Kook; Lee, Ha Young; Seong, Hasoo; Shin, Byung Cheol; Yuk, Soon Hong; Hwang, Sung Joo; Cho, Sun Hang

doi:10.1007/s11671-010-9734-7

Cited by 11 publications

(7 citation statements)

References 28 publications

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Section: Polymeric Mr Contrast Agentsmentioning

confidence: 99%

“…Amphiphilic copolymers of polyhydroxyethylaspartamide have also been used to form micelles of size 180 nm with Gd contrast agents . In vivo study in normal mice showed phagocytosis of these polymeric constructs resulting in accumulation in liver and henceforth used for liver imaging . Two types of amphiphilic diblock copolymers, PCL‐b‐P(OEGMA‐FA) and PCL‐b‐P(OEGMA‐Gd), consisting of a hydrophobic poly(3‐caprolactone) (PCL) block and a hydrophilic poly(oligo(ethylene glycol) monomethyl ether methacrylate) (POEGMA) block was covalently attached with folic acid (FA) and DOTA‐Gd moieties, respectively, and were mixed to form nanosized (28 nm) polymeric micelles .…”

Section: Polymeric Mr Contrast Agentsmentioning

confidence: 99%

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Polymeric nanoparticles for molecular imaging

Srikar

Upendran

Kannan

2014

WIREs Nanomed Nanobiotechnol

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Conventional imaging technologies (X-ray computed tomography, magnetic resonance, and optical) depend on contrast agents to visualize a target site or organ of interest. The imaging agents currently used in clinics for diagnosis suffer from disadvantages including poor target specificity and in vivo instability. Consequently, delivery of low concentrations of contrast agents to region of interest affects image quality. Therefore, it is important to selectively deliver high payload of contrast agent to obtain clinically useful images. Nanoparticles offer multifunctional capabilities to transport high concentrations of imaging probes selectively to diseased site inside the body. Polymeric nanoparticles, incorporated with contrast agents, have shown significant benefits in molecular imaging applications. These materials possess the ability to encapsulate different contrast agents within a single matrix enabling multimodal imaging possibilities. The materials can be surface conjugated to target-specific biomolecules for controlling the navigation under in vivo conditions. The versatility of this class of nanomaterials makes them an attractive platform for developing highly sensitive molecular imaging agents. The research community's progress in the area of synthesis of polymeric nanomaterials and their in vivo imaging applications has been noteworthy, but it is still in the pioneer stage of development. The challenges ahead should focus on the design and fabrication of these materials including burst release of contrasts agents, solubility, and stability issues of polymeric nanomaterials.

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Section: Polymeric Mr Contrast Agentsmentioning

confidence: 99%

Section: Polymeric Mr Contrast Agentsmentioning

confidence: 99%

Polymeric nanoparticles for molecular imaging

Srikar

Upendran

Kannan

2014

WIREs Nanomed Nanobiotechnol

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“…development of polymer-based carriers for MRI CAs with particular reference to Gadolinium (Gd) chelates, which are the most commonly clinically used agents [18,[23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Impact of biopolymer matrices on relaxometric properties of contrast agents

et al. 2016

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Properties of water molecules at the interface between contrast agents (CAs) for magnetic resonance imaging and macromolecules could have a valuable impact on the effectiveness of metal chelates. Recent studies, indeed, demonstrated that polymer architectures could influence CAs' relaxivity by modifying the correlation times of the metal chelate. However, an understanding of the physico-chemical properties of polymer/CA systems is necessary to improve the efficiency of clinically used CAs, still exhibiting low relaxivity. In this context, we investigate the impact of hyaluronic acid (HA) hydrogels on the relaxometric properties of Gd-DTPA, a clinically used CA, to understand better the determining role of the water, which is crucial for both the relaxation enhancement and the polymer conformation. To this aim, water self-diffusion coefficients, thermodynamic interactions and relaxometric properties of HA/Gd-DTPA solutions are studied through time-domain NMR relaxometry and isothermal titration calorimetry. We observed that the presence of Gd-DTPA could alter the polymer conformation and the behaviour of water molecules at the HA/Gd-DTPA interface, thus modulating the relaxivity of the system. In conclusion, the tunability of hydrogel structures could be exploited to improve magnetic properties of metal chelates, inspiring the development of new CAs as well as metallopolymer complexes with applications as sensors and memory devices.

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“…19 As a drug carrier, PHEA has good biopharmaceutical properties, such as high water solubility, multifunctionality, and low production cost. [20][21][22][23][24][25][26][27] …”

Section: Introductionmentioning

confidence: 99%

Biodistribution of newly synthesized PHEA-based polymer-coated SPION in Sprague Dawley rats as magnetic resonance contrast agent

Park¹,

Cho²,

Park³

et al. 2013

IJN

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Objectives The purpose of this study was to observe the pharmacokinetic behavior of newly synthesized biocompatible polymers based on polyhydroxyethylaspartamide (PHEA) to be used to coat an iron oxide core to make superparamagnetic iron oxide nanoparticles (SPION). Materials and methods The isotopes [ 14 C] and [ 59 Fe] were used to label the polymer backbone (CLS) and iron oxide core (FLS), respectively. In addition, unradiolabeled cold superparamagnetic iron oxide nanoparticles (SPION/ULS) were synthesized to characterize particle size by dynamic light scattering, morphology by transmission electron microscopy, and in vivo magnetic resonance imaging (MRI). CLS and FLS were used separately to investigate the behavior of both the synthesized polymer and [Fe] in Sprague Dawley (SD) rats, respectively. Because radioactivity of the isotopes was different by β for CLS and γ for FLS, synthesis of the samples had to be separately prepared. Results The mean particle size of the ULS was 66.1 nm, and the biodistribution of CLS concentrations in various organs, in rank order of magnitude, was liver > kidney > small intestine > other. The biodistribution of FLS concentrations was liver > spleen > lung > other. These rank orders show that synthesized SPION mainly accumulates in the liver. The differences in the distribution were caused by the SPION metabolism. Radiolabeled polymer was metabolized by the kidney and excreted mainly in the urine; [ 59 Fe] was recycled for erythrocyte production in the spleen and excreted mainly in the feces. The MR image of the liver after intravenous injection demonstrated that [Fe] effectively accumulated in the liver and exhibited high-contrast enhancement on T2-weighted images. Conclusion This newly synthesized, polymer-coated SPION appears to be a promising candidate for use as a liver-targeted, biocompatible iron oxide MR imaging agent.

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Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents

Cited by 11 publications

References 28 publications

Polymeric nanoparticles for molecular imaging

Polymeric nanoparticles for molecular imaging

Impact of biopolymer matrices on relaxometric properties of contrast agents

Biodistribution of newly synthesized PHEA-based polymer-coated SPION in Sprague Dawley rats as magnetic resonance contrast agent

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